2001 Fiscal Year Final Research Report Summary

Tissue-specificity of arsenic carcinogenesis - Production mechanism of reactive oxygen species in target organs of arsenic carcinogenesis -

Research Project

Project/Area Number	12672178
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Environmental pharmacy
Research Institution	Nihon University
Principal Investigator	YAMANAKA Kenzo Nihon University, College of Pharmacy, Associate Professor, 薬学部, 助教授 (50182572)
Project Period (FY)	2000 – 2001
Keywords	8-oxodG / oxidative stress / dimethylarsinic acid / arsenic / carcinogenesis
Research Abstract	Recent studies have indicated that oral administration of dimethylarsinic acid (DMA) to rats led to a higher incidence of 8-oxo-2'-deoxyguanosine (8-oxodG) formation in liver and kidney. Therefore, we focused our attention on the induction of oxidative damage in skin, lung, liver and urinary b adder the target organs in arsenic carcinogenesis. The present study is to establish a mouse animal model to understand the mechanism of human arsenic carcinogenesis through the production of oxidative damage. The present findings that the formation of 8-oxodG was observed in skin, lung, liver and urinary bladder in our animal model would be useful for the understanding the arsenic carcinogenesis mechanism in relation to the formation of free radical species.

(2 results)