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2001 Fiscal Year Final Research Report Summary

STUDY ON CORTICAL STIMULATION-EVOKED ANALGESIA IN PERSISTENT PAIN MODELS

Research Project

Project/Area Number 12672233
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 応用薬理学・医療系薬学
Research InstitutionKINKI UNIVERSITY

Principal Investigator

KURODA Ryotaro  KINKI UNIVERSITY, DEPT. OF PATHOPHYSIOLOGY FAC. OF PHARMCEUT SCI., PROFESSOR, 薬学部, 教授 (10161803)

Co-Investigator(Kenkyū-buntansha) KAWABATA Atsufumi  KINKI UNIVERSITY, DEPT. OF PATHOPHYSIOLOGY FAC. OF PHARMCEUT. SCI., ASSOCIATE PROFESSOR, 薬学部, 助教授 (20177728)
Project Period (FY) 2000 – 2001
KeywordsPAR-2 / cortical stimulation / analgesia / hyperalgesia / nociceptive behavior / Fos / NMDA / NO
Research Abstract

The aim of the study was to establish novel animal models in which electrical stimulation of cortical Sll area, known to be clinically analgesic, is capable of producing potent antinociception.
1. Sll stimulation-evoked antinociception in the formalin-induced nociception model : Stimulation electrodes were chronically implanted into the Sll area of the rat. The formalin-induced nociceptive behavior and expression of Fos in the superficial layer of the dorsal horn was slightly reduced by Sll stimulation. Sll stimulation in combination with 7-nitro indazole, a neuronal NO synthase inhibitor, produced strong antinociception and suppression of Fos expression. The effect of Sll stimulation was partially blocked by intrathecal administration of methysergide, a serotonin receptor antagonist, suggesting involvement of the descending serotonin neurons.
2. PAR-2-triggered nociception model and its characterization : Stimulation of PAR-2 expressed in the peripheral terminal of C-fiber triggered thermal hyperalgesia, nociceptive behavior and expression of spinal Fos. The nociceptive processing by PAR-2 was characterized in the present study.
3. Effect of Sll stimulation in the PAR-2-mediated nociception model and the surgically prepared neuropathy model : Sll stimulation failed to exhibit any antinociceptive activity in these two models.
Further effort will be necessary to establish models in which Sll stimulation is highly analgesic.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Kuroda, R. et al.: "Somatosensory cortex stimulationevoked analgesia in rats : potentiation by NO synthase inhibition"Life Sci.. Vol.66. PL271-PL276 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuroda, R. et al.: "Secondary somatosensory cortex stimulation facilitates the antinociceptive effect of the NO synthase inhibitor through suppression of spinal nociceptive neurons in the rat"Brain Res.. Vol.903. 110-116 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawabata, A., Kawao, N., Kuroda, R.et al.: "Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats"NeuroReport. Vol.12. 715-719 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawabata, A., Kawao, N., Kuroda, R.et al.: "Specific expression of spinal Fos after PAR-2 stimulation in mast ceWdepleted rats"NeuroReport. Vol.13(in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuroda, R. et al.: "Somatosensory cortex stimulation-evoked analgesia in rats : potentiation by NO synthase inhibition"Life Sci. 66. PL271-276 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuroda, R. et al.: "Seconday somatosensory cortex stimulation facilitates the antinociceptive effect of the NO synthase inhibitor through suppression of spinal nociceptive neurons in the rat"Brain Res. 903. 110-116 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawabata, A., Kawao, N., Kuroda, R. et al.: "Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats"NeuroReport. 12. 715-719 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawabata, A., Kawao, N., Kuroda, R. et al.: "Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats"NeuroReport. 13(in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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