2001 Fiscal Year Final Research Report Summary
Study on the mechanism of atrophy, hypertrophy and regeneration of the skeletal muscle
| Project/Area Number |
12832031
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Institution | HIROSHIMA UNIVERSITY |
|---|
Principal Investigator |
KAWAMATA Seiichi Institute of Health Sciences, Faculty of Medicine, Hiroshima University, Professor, 医学部, 教授 (30127641)
|
|---|
| Project Period (FY) |
2000 – 2001
|
| Keywords | skeletal muscle / atrophy / cast immobilization / tenotomy / rehabilitation / hypertrophy / synergists ablation / rat |
|---|
| Research Abstract |
CAUSES OF MUSCLE ATROPHY : Cast immobilization of the ankle joint resulted in the atrophy of the gastrocnemius, soleus and plantaris muscles of the rat. The decrease of muscle wet weight was 22% at 1 week and 23% at 2 weeks (22% at 1 week ; 23% at 2 weeks) after immobilization, respectively. Atrophy of these muscles was enhanced when the joint was immobilized at plantar flexion, whereas alleviated at dorsal flexion. Tenotomy produced muscle atrophy (9% at 1 week ; 20% at 2 weeks). Denervation resulted in progressive and serve muscle atrophy (31% at 1 week ; 49% at 2 weeks).
MUSCLE RECOVERY : The atrophied muscles began to reverse after cast removal or reinnervation. Thirty min of swimming once a day for 2 weeks significantly promoted muscle recovery. Prevention of muscle atrophy and promotion of hypertrophy was attempted by muscle stimulation. Muscle contraction for 30 min, but not 15 min, by continuous nerve stimulation produced muscle injury.
CONCLUSIONS : Skeletal muscles rapidly atrophied after immobilization, tenotomy and denervation. Muscle atrophy can be minimized when muscles are loaded with tension. An early start of rehabilitation is effective. However, strong exercise may lead to muscle injury.
|
