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2002 Fiscal Year Final Research Report Summary

Pathophysiological studies on the rehabilitation of the expiratory muscle fatigue

Research Project

Project/Area Number 12832048
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research InstitutionInternational University of Health and Welfare

Principal Investigator

OKUBO Takao  International University of Health and Welfare, School of Health Scinece, Professor, 保健学部, 教授 (40006705)

Project Period (FY) 2000 – 2002
KeywordsRespiratory failure / expiratory muscle fatigue / Chronic obstructive pulmonary diseases / expiratory resistive load / Abdominal muscle load by contractive movements / Respiratory effort sensation / Maximal effort expiratory mouth pressure / Electromyographic records of repiratory muscles
Research Abstract

Expiratory muscle fatigue (EMF) is the most important functional disturbance to develop the respiratory failure in chronic obstructive pulmonary diseases. [PURPOSE] To develop the rehabilitation system of EMF, we have studied (1) which muscles are most responsible for loaded expiration and develop the fatigue, (2) for the purpose of training expiratory muscles, ways of mechanical loads on expiratory muscles were compared between expiratory resistive load and repetition of abdominal contractive movement. [RESULTS] (1) The electromyographic (EMG) activity of M. externus obliqus abdominis revealed high value from low expiratory resistive load, but other muscles (M. rectus abdominis, M. sternocleidomastoides, M. trapezius) does not reveal significant activity according to the increasing expiratory loads. On the other hand, EMG of sternoclidemastoideus revealed the highest value in the inspiratory load; all muscles showed a linear response according to the increasing load. (2) In the group of abdominal muscle loading by curl up, the decrease of P_Emax was smallest, on the contrarily sensation of the abdominal muscle fatigue was increased significantly.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Yamamoto N, Suzuki S., Okubo T. et al.: "Dendritic cells are associated with augmentation of antigen sensitization by influenza A virus infection in mice"Eur J Immunol.. 30(1). 316-326 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Li Fu, Kaneko T, Ikeda H, Nishiyama H, Suzuki S, Okubo T. et al.: "Tachykinin NK2 receptor activation mediate ozone-induced increase in permeability of the tracheal"Brit J Pharmacol. 135. 1331-1335 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinkai M, Suzuki S, Okubo T, et al.: "Analysis of exhaled nitric oxide by the helium bolus method"Chest. 121. 1847-1852 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto N, Suzuki S, Shirai A, Suzuki M, Nakazawa M, Nagashima Y, Okubo T: "Dendritic cells are associated with augmentation of antigen sensitization by influenza. A virus infection in mice"Eur J Immunol. 30(1). 316-326 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Li Fu, Kaneko T, Ikeda H, Nishiyama H, Suzuki S, Okubo T, Trevcisani M, Geppetti P, Ishigatsubo Y: "Tachykinis via Tachykini NK2 receptor activation mediate ozone-induced increase in permeability of the tracheal mucosa in guinea-pigs."Brit J Pharmacol. 135. 1331-1335 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinkai M, Suzuki S, Miyashita A, Kobayashi H, Okubo T, Ishigatsubo Y: "Analysis of exhaled nitric oxide by the helium bolus method"Chest. 121. 1847-1852 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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