2001 Fiscal Year Final Research Report Summary
The usefulness and limitations of MRI for diagnosis of brain disease in small animals
| Project/Area Number |
12833004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OGAWA Hiroyuki Graduate School of Agricultural and Life Sciences, The University of Tokyo, Professor, 大学院・農学生命科学研究科, 教授 (30012016)
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| Co-Investigator(Kenkyū-buntansha) |
MOCHIZUKI Manabu Graduate School of Agricultural and Life Sciences, The University of Tokyo, Assistant Professor, 大学院・農学生命科学研究科, 助手 (90261958)
NISHIMURA Ryohei Graduate School of Agricultural and Life Sciences, The University of Tokyo, Associate Professor, 大学院・農学生命科学研究科, 助教授 (80172708)
SASAKI Nobuo Graduate School of Agricultural and Life Sciences, The University of Tokyo, Professor, 大学院・農学生命科学研究科, 教授 (60107414)
MATSUNAGA Satoru Graduate School of Agricultural and Life Sciences, The University of Tokyo, Assistant Professor, 大学院・農学生命科学研究科, 助手 (60282703)
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| Project Period (FY) |
2000 – 2001
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| Keywords | MRI / Brain disease / dog / Cat |
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| Research Abstract |
1. Evaluation of magnetic resonance imaging technique for small animals Optimum imaging techniques for small animals were evaluated using permanent magnet type MR machine (Hitachi , MRP-ARIS, 0.3T). Then, we decided to use 3 spin echo images (T1 weighed, T2 weighed, and FLAIR imaging) for the routine MRI protocol. Field attenuated inversion recovery (FLAIR) images were diagnostic in various disorders. Higher dose of gadolinium (0.3 m mol/kg) was used for the contrast enhancement of the T1 images because its enhancing ability was lower than that in human images.
2. MRI diagnosis of spontaneous brain disorders in dogs and cats One hundred and fifty seven cases with brain disorders were studied. MR imaging was useful to differentiate functional epilepsy from symptomatic epilepsy, brain tumor, encephalitis, hydrocephalus and other disorders. In dogs, diagnosis of hydrocephalus was very difficult because the size of the lateral ventricle was highly variable between individuals and breeds. So, we assessed ventricular volume in many dog breeds on MR images. Measurements revealed that in common, large dogs have small and consistent lateral ventricle, and small dogs that had predilection to hydrocephalus have comparatively large and variable sized one. Chronic canine distemper encephalitis was suspected in many dog cases, but MRI features of this type of encephalitis was inconsistent and not specific to canine distemper encephalitis. Necrotizing encephalitis (Pug dog encephalitis) was diagnosed in some patients and followed up their clinical courses. Moreover, granulomatous meningoencephalomyelitis was diagnosed in live patients by MRI and CSF analysis. MRI images may help to identify some specific intracranial tumor types, e.g. meningioma. The volume data of the MRI was very useful to determine surgical procedures.
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