2001 Fiscal Year Final Research Report Summary
Effects of Endocrine Disrupters (Environmental Hormone) on Sex-Hormone Target Organs and Mammary Carcinogenesis
| Project/Area Number |
12836013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Institution | Kagoshima University |
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Principal Investigator |
YOSHIDA Hiroki Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (90036476)
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| Co-Investigator(Kenkyū-buntansha) |
OHI Yasuyo Kagoshima University, Faculty of Medicine, Research Associate, 医学部, 助手 (70253862)
UMEKITA Yoshihisa Kagoshima University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (80244226)
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| Project Period (FY) |
2000 – 2001
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| Keywords | Endocrine disruntor / Rat / 7.12-dimethvbenz)a)anthracene / Mammarycarcinoma |
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| Research Abstract |
It has been hypothesized that environmental exposure to synthetic estrogenic chemicals and related endocrine-active compounds may be responsible for a global decrease in sperm counts, decreased male reproductive capacity, and breast cancer in women. Results of our studies showed that administration of diethylstilbestrol (DES), which had high estrogenic activity, disturbed pregnancy and delivery, and induced hypoplasia of testis and absence of corpora lutena in ovaries in Sprague-Dawley rats. Neonatal administration of DES accelerated mammary carcinogenesis in female rats. Neonatal administration of 4-n-octylphenol (n-OP, 1000μg) which exist in the environment and had a very week estrogenic activity, could not induce endocrine disruption in males and females, but oral administration of high dose (1000ppm) n-OP accelerated mammary carcinogenesis in adult male rats. Therefore, further studies on endocrine disruption of fetal n-OP are necessary.
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