2000 Fiscal Year Annual Research Report

フッ素原子による機能の創出

Research Project

Project/Area Number	12895025
Research Institution	Tokyo University of Pharmacy and Life Science
Principal Investigator	田口武夫東京薬科大学, 薬学部, 教授 (00016180)
Co-Investigator(Kenkyū-buntansha)	淵上寿雄東京工業大学, 大学院・総合理工学研究科, 教授 (10016701) 檜山爲次郎京都大学, 大学院・工学研究科, 教授 (90026295) 宇根山健治岡山大学, 工学部, 教授 (00033150) 丸岡啓二京都大学, 大学院・理学研究科, 教授 (20135304) 米田徳彦北海道大学, 大学院・工学研究科, 教授 (50001219)
Keywords	フッ素 / フッ素化 / トルフルオロメチル / ジフルオロメチレン / フルオロアルキル
Research Abstract	極限原子と云うべきフッ素原子の特異性は、機能材料や医農薬など応用分野でのフッ素化合物の利用を拡大してきているが、学術的フッ素化学の基盤研究はその必要性にもかかわらず遅れている。本企画調査研究では、フッ素科学の新展開に関る特定領域研究を組織するため、有機合成化学、有機金属化学、反応機構、医薬品化学、電気化学、材料化学などの分野で活躍する研究者を結集して、「含フッ素超分子の創出」を図るための企画調査を行うものである。2日間の日程で企画調査研究会を開催し、下記の4項目に大別される研究者個々の研究成果情報と最新の国内外の研究情報の集積と整理を総合的に行った。 1)反応機能の開発に関する企画調査(丸岡、三上、檜山、市川、淵上、西口、米田) フッ素原子の特異性を活用する官能基変換、骨格構築法、新規フッ素化法の開発 2)生理活性機能の開発に関する企画調査(田口、沢田、宇根山、松村、山崎) 新規な含フッ素生理活性物質の分子設計のための合成化学、計算化学的研究 3)分子認識機能の開発と基盤的研究に関する企画調査(久保田、友田、竹内、園田) フッ素化合物の分子間相互作用の微視的な解析と機能性物質の創製 4)材料機能の開発に関する企画調査(中島、長村、小野、鄭、柳田) フッ素修飾による材料の改質と新規機能の創出およびフッ素化合物の特性の系統的研究本企画調査により、分子の特定の位置へのフッ素の導入による微視的な構造変化や分子間相互作用の変化さらには機能発現機構の解明などの基盤研究の推進は、今後における新産業を牽引する革新的進展に不可欠な研究課題であるとの認識を強くした。

Research Products

(27 results)

All Other

All Publications (27 results)

[Publications] Takeo Taguchi: "Fluorinated Cyclopropanes"J.Fluorine Chem.. 105. 279-283 (2000)
[Publications] Hideki Amic: "A Practical and Highly Efficient Synthesis of α-(Trimethylsilyl) difluoroacetate."Synthesis. 2001-2003 (2000)
[Publications] Masayuki Mae: "First Synthesis of 3,3-Difluoroserine and Cystein Derivatives via Mg(0)-promoted Selective C-F Bond Cleavage of trifluoromethylimines"Tetrahedron Lett. 41. 7893-7896 (2000)
[Publications] A.Shibato: "Dramatic Enhancement of Reactivity of Organosilicon Compounds Induced by Complexation of Bis(allyl)silanes with Fluoride Ion"Tetrahedron. 56. 5373-5382 (2000)
[Publications] Koichi Mikami: "Lewis Acid Catalysis by Lanthanide Complexes with Tris(perfluorooctasultonyl)methide Ponytails in Fluorous Recyclable Phase"Tetrahedron Lett.. 42. 289-292 (2001)
[Publications] 石井章央: "フルオラールを用いる触媒的不斉合成"有機合成化学協会誌. 58. 324-333 (2000)
[Publications] M.R.Shaaban: "Marked Solvent Effects on Regioselective Anodic Monofluorination of 4-Oxo-2-pyrimidyl Sulfides"J.Org.Chem,. 65. 8685-8689 (2000)
[Publications] K.Kanie: "A Convenient Synthesis of Trifluoromethyl Ethers by Oxidative Desulfurization-Fluorination of Dithiocarbonates"Bull.Chem.Soc.Jpn.. 73. 471-484 (2000)
[Publications] Junji Ichikawa: "The Nucleophilic 5-endo-trig cyclization of gem-Difluoroolefins with Homoallylic Groups"Chem.Commun.. 1887-1888 (2000)
[Publications] Hideo Sawada: "Synthesis and Properties of Novel Fluoroalkyl End-Capped Oligomers Containing Phosphorous Segments"J.Apply.Poly.Sci.. 79. 228-245 (2001)
[Publications] Yoshihiro Matsumura: "A New Method for Synthesis of Unsymmetrical Ureas Using Electrochemically Prepared Trifluoroethyl Carbamates"J.Org.Chem.. 65. 1549-1551 (2000)
[Publications] Tsuyoshi Fukuhara: "Anodic Fluorination of Phonols Using Et_3N-5HF Electrolyte"Electrochemical Commun.. 2. 259-261 (2000)
[Publications] Masanori Yoshida: "Stereo-and Regioselective Synthesis of (E,E) -δ-Fluoro-α,β,γ,δ-unsaturated Carbonyl Compounds by Heck-type Reaction"Tetrahedron Lett.. 41. 3887-3890 (2000)
[Publications] Masanori Sawaguchi: "Electrochemical Fluorodeiododination of Alkyl Iodides"Synlett. 7. 999-1000 (2000)
[Publications] Shuji Tomoda: "A Reversal of π-Facial Diastereoselection in the Hydride Reduction of Solenanones."Tetrahedron Lett.. 41. 4597-4601 (2000)
[Publications] Ikuzo Nishiguchi: "Facile O-Silylation of Tertiary Alcohols in the Presence of Mg-Metal"Synlett. 1025-1027 (2000)
[Publications] Z.Liu: "Novel Methods for the Facile Construction of 3,3-Disubstituted and 3,3-Spiro-2H,4H-benzo-[e]1,2-thiazine-1,1-diones"J.Org.Chem.. 65. 7583-7587 (2000)
[Publications] Fusaji Kita: "Characteristics of the Electrolyte with Fluoro Organic Lithium Salts"J.Power Sorces. 90. 27-32 (2000)
[Publications] Hiroshi Inoue: "Uetrafast Dynamic of Fluorescence-activated CdS Nanoparticles in Aqueous Solutions by Femtosecond Transient Bleaching Spectroscopy"Colloids and Surfaces,A. 169. 233-239 (2000)
[Publications] M.Iwamuro: "Photosensitized Luminescence of β-Diketonato Nd(III) Complexes in Solution"Phys.Chem.Chem.Phys.. 2. 2291-2296 (2000)
[Publications] K.Sogabe: "A New One-pot Synthesis of Bisperfluoroalkanesulfonylamides and Bispentafluorobenzenesulfonylamide as Potassium Salts"Chem.Lett.. 944-945 (2000)
[Publications] 田口武夫(分担): "フッ素系生理活性物質の進歩と応用展開"シーエムシー. 225 (2000)
[Publications] 丸岡啓二: "Catalytic Asymmetric Synthesis,2nd Edition"John Wiley & Sones. 500 (2000)
[Publications] 三上幸一: "Asymmetric Fluoroorganic Chemistry, Synthesis,Applications, and Future Directions"アメリカ化学会. 300 (2000)
[Publications] 檜山爲次郎: "Organofluorine Compounds : Chemistry and Applications"Springer. 272 (2000)
[Publications] A.J.Fry: "New Directions in Organic Electrochemistry"The Electrochemical Society,Inc.. 176 (2000)
[Publications] 中島剛: "Advanced Inorganic Fluorides"Elsevier. 701 (2000)

2000 Fiscal Year Annual Research Report

フッ素原子による機能の創出

Principal Investigator

田口 武夫 東京薬科大学, 薬学部, 教授 (00016180)

Research Products

[Publications] Takeo Taguchi: "Fluorinated Cyclopropanes"J.Fluorine Chem.. 105. 279-283 (2000)

[Publications] Hideki Amic: "A Practical and Highly Efficient Synthesis of α-(Trimethylsilyl) difluoroacetate."Synthesis. 2001-2003 (2000)

[Publications] Masayuki Mae: "First Synthesis of 3,3-Difluoroserine and Cystein Derivatives via Mg(0)-promoted Selective C-F Bond Cleavage of trifluoromethylimines"Tetrahedron Lett. 41. 7893-7896 (2000)

[Publications] A.Shibato: "Dramatic Enhancement of Reactivity of Organosilicon Compounds Induced by Complexation of Bis(allyl)silanes with Fluoride Ion"Tetrahedron. 56. 5373-5382 (2000)

[Publications] Koichi Mikami: "Lewis Acid Catalysis by Lanthanide Complexes with Tris(perfluorooctasultonyl)methide Ponytails in Fluorous Recyclable Phase"Tetrahedron Lett.. 42. 289-292 (2001)

[Publications] 石井章央: "フルオラールを用いる触媒的不斉合成"有機合成化学協会誌. 58. 324-333 (2000)

[Publications] M.R.Shaaban: "Marked Solvent Effects on Regioselective Anodic Monofluorination of 4-Oxo-2-pyrimidyl Sulfides"J.Org.Chem,. 65. 8685-8689 (2000)

[Publications] K.Kanie: "A Convenient Synthesis of Trifluoromethyl Ethers by Oxidative Desulfurization-Fluorination of Dithiocarbonates"Bull.Chem.Soc.Jpn.. 73. 471-484 (2000)

[Publications] Junji Ichikawa: "The Nucleophilic 5-endo-trig cyclization of gem-Difluoroolefins with Homoallylic Groups"Chem.Commun.. 1887-1888 (2000)

[Publications] Hideo Sawada: "Synthesis and Properties of Novel Fluoroalkyl End-Capped Oligomers Containing Phosphorous Segments"J.Apply.Poly.Sci.. 79. 228-245 (2001)

[Publications] Yoshihiro Matsumura: "A New Method for Synthesis of Unsymmetrical Ureas Using Electrochemically Prepared Trifluoroethyl Carbamates"J.Org.Chem.. 65. 1549-1551 (2000)

[Publications] Tsuyoshi Fukuhara: "Anodic Fluorination of Phonols Using Et_3N-5HF Electrolyte"Electrochemical Commun.. 2. 259-261 (2000)

[Publications] Masanori Yoshida: "Stereo-and Regioselective Synthesis of (E,E) -δ-Fluoro-α,β,γ,δ-unsaturated Carbonyl Compounds by Heck-type Reaction"Tetrahedron Lett.. 41. 3887-3890 (2000)

[Publications] Masanori Sawaguchi: "Electrochemical Fluorodeiododination of Alkyl Iodides"Synlett. 7. 999-1000 (2000)

[Publications] Shuji Tomoda: "A Reversal of π-Facial Diastereoselection in the Hydride Reduction of Solenanones."Tetrahedron Lett.. 41. 4597-4601 (2000)

[Publications] Ikuzo Nishiguchi: "Facile O-Silylation of Tertiary Alcohols in the Presence of Mg-Metal"Synlett. 1025-1027 (2000)

[Publications] Z.Liu: "Novel Methods for the Facile Construction of 3,3-Disubstituted and 3,3-Spiro-2H,4H-benzo-[e]1,2-thiazine-1,1-diones"J.Org.Chem.. 65. 7583-7587 (2000)

[Publications] Fusaji Kita: "Characteristics of the Electrolyte with Fluoro Organic Lithium Salts"J.Power Sorces. 90. 27-32 (2000)

[Publications] Hiroshi Inoue: "Uetrafast Dynamic of Fluorescence-activated CdS Nanoparticles in Aqueous Solutions by Femtosecond Transient Bleaching Spectroscopy"Colloids and Surfaces,A. 169. 233-239 (2000)

[Publications] M.Iwamuro: "Photosensitized Luminescence of β-Diketonato Nd(III) Complexes in Solution"Phys.Chem.Chem.Phys.. 2. 2291-2296 (2000)

[Publications] K.Sogabe: "A New One-pot Synthesis of Bisperfluoroalkanesulfonylamides and Bispentafluorobenzenesulfonylamide as Potassium Salts"Chem.Lett.. 944-945 (2000)

[Publications] 田口武夫(分担): "フッ素系生理活性物質の進歩と応用展開"シーエムシー. 225 (2000)

[Publications] 丸岡啓二: "Catalytic Asymmetric Synthesis,2nd Edition"John Wiley & Sones. 500 (2000)

[Publications] 三上幸一: "Asymmetric Fluoroorganic Chemistry, Synthesis,Applications, and Future Directions"アメリカ化学会. 300 (2000)

[Publications] 檜山爲次郎: "Organofluorine Compounds : Chemistry and Applications"Springer. 272 (2000)

[Publications] A.J.Fry: "New Directions in Organic Electrochemistry"The Electrochemical Society,Inc.. 176 (2000)

[Publications] 中島剛: "Advanced Inorganic Fluorides"Elsevier. 701 (2000)

田口武夫東京薬科大学, 薬学部, 教授 (00016180)