Dynamics of signal transduction in the system of organogenesis and regeneration

2005 Fiscal Year Final Research Report Summary

• Project/Area Number: 13044002
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: YASUGI Sadao Tokyo Metropolitan University, Dept of Biological Sciences, Professor, 都市教養学部, 教授 (70011591)
• Co-Investigator(Kenkyū-buntansha): ASASHIMA Makoto University of Tokyo, Graduate School of Arts and Sciences, Professor, 大学院総合文化研究科, 教授 (00090564) ; KUROIWA Atsushi Nagoya University, Division of Biological Science, Professor, 大学院理学研究科, 教授 (20134611) ; OGURA Toshihiko Inst. of Development, Aging and Cancer, Tohoku University, Professor, 加齢医学研究所, 教授 (60273851) ; TABATA Tetsuya University of Tokyo, Institute of Molecular and Cellular Biosciences, Professor, 分子細胞生物学研究所, 教授 (10183865) ; AGATA Kiyokazu Kyoto University, Department of Biophysics, Graduate School of Sciences, Professor, 発生・再生科学総合研究センター, グループディレクター (70167831)
• Project Period (FY): 2001 – 2005
• Keywords: organogenesis / tissue interaction / transduction / growth factor / transcrition factor / cell differentiation / regenerative medicine

Research Abstract

In 2005, the networks of gene expressions in the formation of many organ systems have been analyzed. In planarians, two more noggin-like genes were identified and role of these genes in the establishment of body axis was demonstrated (Agata). In amphibians, the function of MA35, a newly found gene involved in the heart formation, was examined. Also Wnt signaling cascade in the early stages of development was extensively studied. These investigations opened a new horizon of organogenesis research in amphibians (Asashima). Co-factors necessary for the transcription of TbxS were identified. Knockdown of some of them in zebrafish showed close relationship between transcriptional control and cytoskeletal system (Ogura). In the course of cartilage formation during the limb development, Hox genes determine the positional characteristics of pre- cartilage cell mass. It was also found that ephrin-b1 and EphB2 function as downstream cell adhesion factors (Kuroiwa). In Drosophila visual system, the suppression of JAK/STAT signal resulted in the shift of lamina neuron to medulla neuron. The JAK/STAT and Notch signals are suggested to regulate multistep differentiation of neurons from the neural stem cells (Tabata). Wnt5a was found to regulate cell differentiation of the epithelium in the glandular stomach of the chicken embryo. Overexpression and suppression of this gene resulted in the overexrpession and/or ectopic expression of some region-specific marker genes of the epithelium. (Yasugi)

Research Products

• [Journal Article] DWnt4 regulates dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system. (2006)
  • Author(s): Sato, M., Umetsu, D., Murakami, S., Yasugi, T., Tabata,.
  • Journal Title: Nature Neurosci. 9 Pages: 67-75
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. (2006)
  • Author(s): Osafune, K., Takasato, M., Kispert, A., Asashima, M., Nishinakamura, R.
  • Journal Title: Development 133(1) Pages: 151-161
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system. (2006)
  • Author(s): Sato, M., Umetsu, D., Murakami, S., Yasugi, T., *Tabata, T.
  • Journal Title: Nature Neurosci. 9 Pages: 67-75
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. (2006)
  • Author(s): Osafune, K., Takasato, M., Kispert, A., Asashima, M., *Nishinakamura, R.
  • Journal Title: Development 133(1) Pages: 151-161
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development. (2005)
  • Author(s): Matsuda, Y., Wakamatsu, Y., Kohyama, J., Okano, H., Fukuda, K., Yasugi, S.
  • Journal Title: Development 132 Pages: 2783-2793
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Notch signaling modulates the unclear localization of carboxyl-terminal-phosphorylated smad2 and controls the competence of ectodermal cells for activen A. (2005)
  • Author(s): Abe, T., Furue, M., Kondow, A., Matsuzaki, K., Asashima, M.
  • Journal Title: Mech.Dev. 122 Pages: 671-680
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Highly ordered assembly of retinal axons and their synaptic partners is regulated by Hedgehog/Single-minded in Drosophilavisual system. (2005)
  • Author(s): Umetsu, D., Murakami, S., Sato, M.Tabata, T.
  • Journal Title: Development 133 Pages: 791-800
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Requirements of genetic interactions between Src42A, armadillo and (2005)
  • Author(s): Takahashi, M., Takahashi, F., Ui-Tei, K., Kojima, T., Saigo, K.
  • Journal Title: Development 132 Pages: 2547-2559
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Asymmetric cortical and nuclear localizations of WRM1/b-catenin during asymmetric cell division in C.elegans. (2005)
  • Author(s): Takeshita, H., Sawa, H.
  • Journal Title: Genes Dev. 19 Pages: 1743-1748
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Potentiation of the ligand-binding activity of integrin alpha3etal via association with tetraspanin CD151. (2005)
  • Author(s): Nishiuchi, R., Sanzen, N., Nada, S., Wada, Y., Takagi, J., Okada, M., Hasegawa, H., Sekiguchi, K.
  • Journal Title: Proc.Natl.Acad.Sci.USA 102 Pages: 1934-1944
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. (2005)
  • Author(s): Morimoto, M., Takahashi, Y., Endo, M., Saga, Y.
  • Journal Title: Nature 435 Pages: 354-359
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Hym-301, a novel peptide, regulates the number of tentacles formed in hydra. (2005)
  • Author(s): Takahashi, T., Hatta, M., Yum, S., Koizumi, O., Kobayakawa, Y., Gee, L., Ohtani, M., Fujisawa, T., Bode, H.R.
  • Journal Title: Development 132 Pages: 2225-2234
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A Drosophila model of congenital disorder of glycosylation IIc implicates the deficiency of Notch signaling in its pathogenesis. (2005)
  • Author(s): Ishikawa, H.O., Higashi, S., Ayukawa, T., Sasamura, T., Aoki, K., Ishida N., Sanai, Y., Matsuno, K.
  • Journal Title: Proc.Natl.Acad.Sci.USA 102 Pages: 18532-18537
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mesonephric FGF signaling is associated with the development of sexually indifferent gonadal primordium in chick embryos. (2005)
  • Author(s): Yoshioka, H., Ishimaru, Y., Sugiyama, N., Tsunekawa, N., Noce, T., Kasahara, M., Morohashi, K.
  • Journal Title: Dev.Biol. 280 Pages: 150-161
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development. (2005)
  • Author(s): Matsuda, Y., Wakamatsu, Y., Kohyama, J., Okano, H., Fukuda, K., *Yasugi, S.
  • Journal Title: Development 132 Pages: 2783-2793
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] signaling modulates the nuclear localization of carboxyl-terminal- phosphorylated smad2 and controls the competence of ectodermal cells for activ in A. (2005)
  • Author(s): Abe, T., Fume, M., Kondow, A., Matsuzaki, K., *Asashima.M.Notch
  • Journal Title: Mech. Dev. 122 Pages: 671-680
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Highly ordered assembly of retinal axons and their synaptic partners is regulated by Hedgehog/Single-minded in Drosophilavisual system. (2005)
  • Author(s): Umetsu, D., Murakami, S., Sato, M., *Tabata, T.
  • Journal Title: Development 133 Pages: 791-800
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Requirements of genetic interactions between Src42A, armadillo and shotgun, a gene encoding E-cadherin, for normal development in Drosophila. (2005)
  • Author(s): Takahashi, M., Takahashi, F., Ui-Tei, K., Koiima.T.., *Saigo, K.
  • Journal Title: Development 132 Pages: 2547-2559
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Asymmetric cortical and nuclear localizations of WRM1/b-catenin during asymmetric cell division in C. elegans. (2005)
  • Author(s): Takeshita, H., *Sawa, H.
  • Journal Title: Genes Dev. 19 Pages: 1743-1748
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Potentiation of the ligand-binding activity of integrin alpha3etal via association with tetraspanin CD151. (2005)
  • Author(s): Nishiuchi, R., Sanzen, N., Nada, S., Wada, Y., Takagi, J., Okada, M., Hasegawa, H., *Sekiguchi, K.
  • Journal Title: Proc. Natl. Acad. Sci. USA 102 Pages: 1934-1944
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. (2005)
  • Author(s): Morimoto, M., Takahashi, Y., Endo, M., *Saga, Y.
  • Journal Title: Nature 435 Pages: 354-359
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hym-301, a novel peptide, regulates the number of tentacles formed in hydra. (2005)
  • Author(s): Takahashi, T., Hatta, M., Yum, S., Koizumi, 0., Kobayakawa, Y., Gee, L., Ohtani, M., Fujisawa, T., *Bode, H.R.
  • Journal Title: Development 132 Pages: 2225-2234
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Drosophila model of congenital disorder of glycosylation He implicates the deficiency of Notch signaling in its pathogenesis. (2005)
  • Author(s): Ishikawa, H.0., Higashi, S., Ayukawa, T, Sasamura, T., Aoki, K., Ishida N., Sanai, Y., *Matsuno, K.
  • Journal Title: Proc. Natl. Acad. Sci. USA 102 Pages: 18532-1537
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mesonephric FGF signaling is associated with the development of sexually indifferent gonadal primordium in chick embryos. (2005)
  • Author(s): Yoshioka, H., Ishimaru, Y., Sugiyama, N., Tsunekawa, N., Noce, T., Kasahara, M., Morohashi, K.
  • Journal Title: Dev. Biol. 280 Pages: 150-161
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Six1 controls patterning of the mouse otic vesible. (2004)
  • Author(s): Ozaki, H., Nakamura, K., Funahashi, J., Ikeda, K., Yamada, G., Tokano, H., Okamura, H.O., Kitamura, K., Muto, S., Kotaki, H., Sudo, K., Horai, R., Iwakura, Y., Kawakami, K.
  • Journal Title: Development 131 Pages: 551-564
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Misrouting of mitral cell progenitors in the Pax6/Small eyerat telencephalon. (2004)
  • Author(s): Nomura, T., Osumi, N.
  • Journal Title: Development 131 Pages: 787-796
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling. (2004)
  • Author(s): Hori, K., Fostier, M., Ito, M., Fuwa, J.T., Go, M., Okano, H., Martin Baron, M., Matsuno, K.
  • Journal Title: Development 131 Pages: 5527-5537
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Molecular analysis of the determination of developmental fate in the small intestinal epithelium in the chicken embryo. (2004)
  • Author(s): Hiramatsu, H., Yasugi, S.
  • Journal Title: Int.J.Dev.Biol. 48 Pages: 1141-1148
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Morphogens, their identification and regulation. (2004)
  • Author(s): Tabata, T., Takei, Y.
  • Journal Title: Development 131(4) Pages: 703-712
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression patterns of Xenopus FGF receptor-like 1/nou-darake in early Xenopus development resemble those of planarian nou-darake and Xenopus FGF8. (2004)
  • Author(s): Hayashi, S., Itoh, M., Taira, S., Agata, K., Taira, M.
  • Journal Title: Dev.Dyn. 230 Pages: 700-707
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg. (2004)
  • Author(s): Kojima, T., Tsuji, T., Saigo, K.
  • Journal Title: Dev.Biol. 279 Pages: 434-445
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Molecular dissection of the alpha-dystroglycanand integrin-binding sites within the globular domain of human laminin-10. (2004)
  • Author(s): Ido, H., Harada, K., Futaki, S., Hayashi, Y., Nishiuchi, R., Natsuka, Y., Li, S., Wada, Y., Combs, A.C., Ervasti, J.M., Sekiguchi, K.
  • Journal Title: J.Biol.Chem. 279 Pages: 10946-10954
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. (2004)
  • Author(s): Usui, M., Noda, M.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 6653-6658
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The ACR4 receptor-like kinase is required for surface formation of epidermis-related tissues in Arabidopsis thaliana. (2004)
  • Author(s): Watanabe, M., Tanaka, H., Machida, C.Watanabe, D., Machida, Y
  • Journal Title: Plant J. 39 Pages: 298-308
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Six 1 controls patterning of the mouse otic vesible. (2004)
  • Author(s): Ozaki, H., Nakamura, K., Funahashi, J., Ikeda, K., Yamada, G., Tokano, H., Okamura, H.O., Kitamura, K., Muto, S., Kotaki, H., Sudo, K., Horai, R., Iwakura, Y., *Kawakami, K.
  • Journal Title: Development 131 Pages: 551-564
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Misrouting of mitral cell progenitors in the Pax6/Small eye rat telencephalon. (2004)
  • Author(s): Nomura, T., *Osumi, N.
  • Journal Title: Development 131 Pages: 787-796
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular analysis of the determination of developmental fate in the small intestinal epithelium in the chicken embryo. (2004)
  • Author(s): Hiramatsu, H., *Yasugi, S.
  • Journal Title: Int. J. Dev. Biol. 48 Pages: 1141-1148
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] their identification and regulation. (2004)
  • Author(s): Tabata, T., Takei, Y.Morphogens
  • Journal Title: Development 131 (4) Pages: 703-712
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression patterns of Xenopus FGF receptor-like 1 /nou-darake in early Xenopus development resemble those of planarian nou-darake and Xenopus FGF8. (2004)
  • Author(s): Hayashi, S., Itoh, M., Taira, S., Agata, K., *Taira, M.
  • Journal Title: Dev. Dyn. 230 Pages: 700-707
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox 11 /tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg. (2004)
  • Author(s): Kojima, T., Tsuji, T., Saigo, K.
  • Journal Title: Dev. Biol. 279 Pages: 434-445
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular dissection of the alpha-dystroglycanand integrin-binding sites within the globular domain of human laminin-10. (2004)
  • Author(s): Ido, H., Harada, K., Futaki, S., Hayashi, Y., Nishiuchi, R., Natsuka, Y., Li, S., Wada, Y., Combs, A.C., Ervasti, J.M., *Sekiguchi, K.
  • Journal Title: J. Biol. Chem. 279 Pages: 10946-10954
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. (2004)
  • Author(s): Usui, M., *Noda, M.
  • Journal Title: Proc. Natl. Acad. Sci. U SA 101 Pages: 6653-6658
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The ACR4 receptor-like kinase is required for surface formation of epidermis-related tissues in Arabidopsis thaliana. (2004)
  • Author(s): Watanabe, M., Tanaka, H., Machida, C., Watanabe, D, *Machida, Y
  • Journal Title: Plant J. 39 Pages: 298-308
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling. (2004)
  • Author(s): Hori, K., Fostier, M., Ito, M., Fuwa, J.T., Go, M., Okano, H., Martin Baron, M., *Matsuno, K.
  • Journal Title: Development 131 Pages: 5527-5537
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis. (2003)
  • Author(s): Takeushi, J.K., Ohgi, M., Koshiba-Takeuchi, K., Shiratori, H., Sasaki, I., Ogura, K., Saijoh, Y., Ogura, T.
  • Journal Title: Development 130 Pages: 5953-5964
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs. (2003)
  • Author(s): Mineta, K., Nakagawa, M., cebria, F., Ikeo, K., Agata, K., Gojobori, T.
  • Journal Title: Proc.Natl.Acad.Sci.USA 100 Pages: 7666-7671
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C.elegans. (2003)
  • Author(s): Zhao, S., Sawa, H., Herman, M.A.
  • Journal Title: Dev.Biol. 256 Pages: 276-289
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CD151 regulates epithelial cell-cell adhesion through PKC-and Cdc42-dependent actin cytoskeletal reorganization. (2003)
  • Author(s): Shigeta, M., Sanzen, N., Gu, J., Haswgawa, T., Sekiguchi, K.
  • Journal Title: J.Cell Biol. 163 Pages: 165-176
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cell-autonomous involvement of Mab2111 is essential for lens placode development. (2003)
  • Author(s): Yamada, R., Mizutani-Koseki, Y., Hasegawa, T., Osumi, N., Koseki, H., Takahashi, N.
  • Journal Title: Development 130 Pages: 1759-1770
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Feedback loops comprising Dll1,Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites. (2003)
  • Author(s): Takahashi, Y., Inoue, T., Gossler, A., Saga, Y.
  • Journal Title: Development 130 Pages: 4259-4268
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. (2003)
  • Author(s): Nishida, A., Furukawa, A., Koike, C., Tano, Y., Aizawa, S., Matsuo, I., Furukawa, T.
  • Journal Title: Nature Neurosci. 6 Pages: 1255-1263
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. (2003)
  • Author(s): Sasamura, T., Sasaki, N., Miyashita, F., Nakao, S., Ishikawa, H., Ito, M., Kitagawa, M., Harigaya, K., Spana, E., Bilder, D., Perrimon, N., Matsuno, K.
  • Journal Title: Development 130 Pages: 4785-4795
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis. (2003)
  • Author(s): Takeuchi, J.K., Ohgi, M., Koshiba-Takeuchi, K., Shiratori, H., Sasaki, I., Ogura, K., Saijoh, Y., *Ogura, T.
  • Journal Title: Development 130 Pages: 5953-5964
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs. (2003)
  • Author(s): Mineta, K., Nakagawa, M., cebria, R, Ikeo, K., Agata.K.., *Gojobori, T.
  • Journal Title: Proc. Natl. Acad. Sci. USA 100 Pages: 7666-7671
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C. elegans. (2003)
  • Author(s): Zhao, S., Sawa, H., *Herman, M.A.
  • Journal Title: Dev. Biol. 256 Pages: 276-289
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CD151 regulates epithelial cell-cell adhesion through PKC-and Cdc42-dependent actin cytoskeletal reorganization. (2003)
  • Author(s): Shigeta, M., Sanzen, N., Gu, J., Hasegawa, T., *Sekiguchi, K.
  • Journal Title: J. Cell Biol. 163 Pages: 165-176
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cell-autonomous involvement of Mab2111 is essential for lens placode development. (2003)
  • Author(s): Yamada, R., Mizutani-Koseki, Y., Hasegawa, T., Osumi, N., Koseki, H., *Takahashi, N.
  • Journal Title: Development 130 Pages: 1759-1770
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Feedback loops comprising Dill, D113 and Mesp2, and differential involvement of Psenl are essential for rostrocaudal patterning of somites. (2003)
  • Author(s): Takahashi, Y., Inoue, T., Gossler, A., *Saga, Y.
  • Journal Title: Development 130 Pages: 4259-4268
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. (2003)
  • Author(s): Nishida, A., Furukawa, A., Koike, C., Tano, Y., Aizawa, S., Matsuo, I, *Furukawa, T.
  • Journal Title: Nature Neurosci. 6 Pages: 1255-1263
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] neurotic, a novel maternal neurogenic gene, encodes an 0- fucosyltransferase that is essential for Notch-Delta interactions. (2003)
  • Author(s): Sasamura, T., Sasaki, N., Miyashita, F., Nakao, S., Ishikawa, H.O., Ito, M., Kitagawa, M., Harigaya, K., Spana, E., Bilder, D., Perrimon, N., *Matsuno, K.
  • Journal Title: Development 130 Pages: 4785-4795
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvment of the signal transduction pathway mediated by epidermal growth factor receptor in the differentiation of chicken glandular stomach. (2002)
  • Author(s): Takeda, J., Tabata, H., Fukuda, K.Yasugi, S.
  • Journal Title: Dev.Growth＆Differ. 44 Pages: 501-508
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The pre-gut endoderm of chick embryo is reginolized by 1.5 days of development. (2002)
  • Author(s): Matsushita, S., Ishii, Y., Scotting, P.J., Kuroiwa, A., Yasugi, S.
  • Journal Title: Dev.Dyn. 223 Pages: 33-47
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Activin A induces craniofacial cartilage from undifferentiated Xenopus ectoderm in vitro. (2002)
  • Author(s): Furue, M., Myoishi, Y., Fukui, Y., Ariizumi, T., Okamoto, T., Asashima, M.
  • Journal Title: Proc.Natl.Acad.Sci.USA 99(24) Pages: 1547-1579
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transition of Hox expression during limb cartilage development. (2002)
  • Author(s): Suzuki, M., Kuroiwa, A.
  • Journal Title: Mech.Dev. 118 Pages: 241-245
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Involvment of the signal transduction pathway mediated by epidermal growth factor receptor in the differentiation of chicken glandular stomach. (2002)
  • Author(s): Takeda, J., Tabata, H., Fukuda, K., *Yasugi, S.
  • Journal Title: Dev. Growth ＆ Differ. 44 Pages: 501-508
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The pre-gut endoderm of chick embryo is reginolized by 1.5 days of development. (2002)
  • Author(s): Matsushita, S., Ishii, Y., Scotting, P.J., Kuroiwa, A., *Yasugi, S.
  • Journal Title: Dev. Dyn. 233 Pages: 33-47
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Activin A induces craniofacial cartilage from undifferentiated Xenopus ectoderm in vitro. (2002)
  • Author(s): Furue, M., Myoishi, Y., Fukui, Y., Ariizumi, T., Okamoto, T., *Asashima, M.
  • Journal Title: Proc. Natl. Acad. Sci. USA 99(24) Pages: 1574-1579
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transition of Hox expression during limb cartilage development. (2002)
  • Author(s): Suzuki, M., *Kuroiwa, A.
  • Journal Title: Mech. Dev. 118 Pages: 241-245
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genetics of morphogen gradients (2001)
  • Author(s): Tabata, T.
  • Journal Title: Nature 2 Pages: 620-630
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Dorsal and ventral positional cues required for the onset of planarian regeneration May reside in differentiated cells. (2001)
  • Author(s): Kato, K., Orii, H., Watanabe, K., Agata, K.
  • Journal Title: Dev.Biol. 239 Pages: 241-256
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Diffusion of Nodal Signaling Activity in the Absence of the Feedback Inhibitor Lefty2. (2001)
  • Author(s): Meno, C., Takeushi, J., Sakuma, R., Koshiba-Takeuchi, K., Ohishi, S., Saijoh, Y., Miyazaki, J., Dijike, P., Ogura, T., Hamada, H.
  • Journal Title: Dev.Cell. 1 Pages: 127-138
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] HoxA and HoxB cluster genes subdivide the digestive tract in to morphological domains during chick development. (2001)
  • Author(s): Sakiyama, J., Yokouchi, Y., Kuroiwa, A.
  • Journal Title: Mech.Dev. 101 Pages: 233-236
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Translational repression determines a neuronal potential in Drosophila asymmetric cell division. (2001)
  • Author(s): Okabe, M., Imai, T., Kurusu, M., Hiromi, Y., Okano, H.
  • Journal Title: Nature 411 Pages: 94-98
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. (2001)
  • Author(s): Takizawa, T., Nakashima, K., Namihira, M., Ochiai, W., Uemaura, A., Yanagisawa, M., Fujita, N., Nakao, M., Taga, T.
  • Journal Title: Dev.Cell 1 Pages: 749-758
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. (2001)
  • Author(s): Nishinakamura, R., Matsumoto, Y., Nakao, K., Nakamura, K., Sato, A., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Scully, S., Lacey, D.L., Katsuki, M., Asashima, M., Yokota, T.
  • Journal Title: Development 128 Pages: 3105-3115
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Embryonic and larval development of the Drosophila mushroom bodies : concentric layer subdivisions and the role of Fasciclin II. (2001)
  • Author(s): Kurusu, M., Awasaki, T., Masuda-Nakagawa, L.M., Kawauchi, H., Ito, K., Furukubo-Tokunaga, K.
  • Journal Title: Development 129 Pages: 40-419
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana regulates lamina formation, establishment of venation and repression of meristem-related homeobox genes in the leaf. (2001)
  • Author(s): Semiarti, E., Ueno, Y., Tsukaya, H., Iwakawa, H., Machida, C., Machida, Y.
  • Journal Title: Development 128 Pages: 1771-1783
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Liver organogenesis promoted by endothelial cells prior to vascular function. (2001)
  • Author(s): Matsumoto, K., Yoshitomi, H., Rossant, J., Zaret, K.
  • Journal Title: Science 294 Pages: 559-563
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Genetics of morphogen gradients. (2001)
  • Author(s): Tabata, T.
  • Journal Title: Nature Reviews Genetics 2 Pages: 620-630
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dorsal and ventral positional cues required for the onset of planarian regeneration May reside in differentiated cells. (2001)
  • Author(s): Kato, K., Orii, H., Watanabe, K., *Agata, K.
  • Journal Title: Dev. Biol. 239 Pages: 241-256
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Diffusion of Nodal Signaling Activity in the Absence of the Feedback Inhibitor (2001)
  • Author(s): Meno, C., Takeuchi, J., Sakuma, R., Koshiba-Takeuchi, K., Ohishi, S., Saijoh, Y., Miyazaki, J., Dijike, P., Ogura, T., *Hamada, H.
  • Journal Title: Lefty2. Dev. Cell 1 Pages: 127-138
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] HoxA and HoxB cluster genes subdivide the digestive tract into morphological domains during chick development. (2001)
  • Author(s): Sakiyama, J., Yokouchi, Y., *Kuroiwa, A.
  • Journal Title: Mech. Dev. 101 Pages: 233-236
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Translational repression determines a neuronal potential in Drosophila asymmetric cell division (2001)
  • Author(s): Okabe, M., Imai, T., Kurusu, M., Hiromi, Y., *Okano, H.
  • Journal Title: Nature 411 Pages: 94-98
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. (2001)
  • Author(s): Takizawa, T., Nakashima, K., Namihira, M., Ochiai, W., Uemaura, A., Yanagisawa, M., Fujita, N., Nakao, M., *Taga, T.
  • Journal Title: Dev. Cell 1 Pages: 749-758
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. (2001)
  • Author(s): Nithinakamura, R・Matsumoto, Y., Nakao, K., Nakamura, K., Sato, A., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Scully, S., Lacey, D.L., Katsuki, M., Asashima, M., Yokota, T.
  • Journal Title: Development 128 Pages: 3105-3115
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Embryonic and larval development of the Drosophila mushroom bodies : concentric layer subdivisions and the role of Fasciclin II. (2001)
  • Author(s): Kurusu, M., Awasaki, T., Masuda-Nakagawa, L.M., Kawauchi, H., Ito, K., *Furukobo-Tokunaga, K.
  • Journal Title: Development 129 Pages: 40-419
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana regulates lamina formation, establishment of venation and repression of meristem-related homeobox genes in the leaf. (2001)
  • Author(s): Semiarti, E., Ueno, Y., Tsukaya, H., Iwakawa, H., Machida, C., *Machida, Y.
  • Journal Title: Development 128 Pages: 1771-1783
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Liver organogenesis promoted by endothelial cells prior to vascular function. (2001)
  • Author(s): Matsumoto, K., Yoshitomi, H., Rossant, J., *Zaret, K.
  • Journal Title: Science 294 Pages: 559-563
  • Description: 「研究成果報告書概要(欧文)」より
• [Patent(Industrial Property Rights)] 細胞分化誘導法 (2005)
  • Inventor(s): 中山泰秀, 黄海瑛, 安藤譲二, 山下潤, 伊藤裕, 神田圭一, 岡本吉弘, 根元泰
  • Industrial Property Rights Holder: 国立循環器病センター総長, 株式会社ブリジストン
  • Industrial Property Number: 2005-066683
  • Filing Date: 2005-03-10
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] ES細胞の分化誘導方法 (2005)
  • Inventor(s): 昭苑, 白木伸明, 吉田 哲, 後藤秀夫, 粂 和彦
  • Industrial Property Rights Holder: 国立大学法人熊本大学
  • Industrial Property Number: 特願2005-150800
  • Filing Date: 2005-05-24
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] DNAとcDNAクローンの対応方法及び対応表を記録した記録媒体, 並びにcDNA検索サービス提供方法及びcDNA検索サービス提供サーバ (2005)
  • Inventor(s): 仲嶋一範, 前田卓哉, 味岡逸樹
  • Industrial Property Rights Holder: 学校法人慶応義塾
  • Industrial Property Number: 特願2005-227223号
  • Filing Date: 2005-08-04
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 動脈内皮細胞の判別方法 (2004)
  • Inventor(s): 中山泰秀, 黄長澤 丘司, 山下潤, 小林 貴美, 荒 敏昭
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Number: 2004-379799
  • Filing Date: 2004-12-28
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 霊長類動物胚性幹細胞から発生初期血管内皮細胞の製造方法及びその細胞の使用 (2004)
  • Inventor(s): 中尾一和, 伊藤裕, 山下 潤, 曽根正勝, 山原研一, 近藤靖, 鈴木 豊
  • Industrial Property Rights Holder: 田辺製薬株式会社
  • Industrial Property Number: 2004-184138
  • Filing Date: 2004-06-22
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 組織特異的に細胞増殖を制御する遺伝子 (2003)
  • Inventor(s): 高橋直樹, 山田竜一, 古関明彦, 古関庸子, 長谷川孝徳, 大隈典子
  • Industrial Property Rights Holder: 財団法人奈良先端科学技術大学院大学支援財団
  • Industrial Property Number: 特願2003-143311
  • Filing Date: 2003-05-21
  • Acquisition Date: 2004-12-09
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] cDNA encoding a BMP type II receptor (2001)
  • Inventor(s): J.S.Rosenbaum, T.Nohno
  • Industrial Property Rights Holder: United States Patent
  • Industrial Property Number: No.6,306,622 B1
  • Filing Date: 2001-10-23
  • Description: 「研究成果報告書概要(和文)」より