2003 Fiscal Year Annual Research Report

頭部形成の分子機構

Research Project

Project/Area Number	13138101
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	相沢慎一独立行政法人理化学研究所, ボディプラン研究グループ, グループディレクター (60073011)
Co-Investigator(Kenkyū-buntansha)	倉谷滋独立行政法人理化学研究所, 形態進化研究チーム, チームリーダー (00178089) 武田洋幸東京大学, 理学系研究科, 教授 (80179647) 影山龍一郎京都大学, ウイルス研究所, 教授 (80224369) 松尾勲独立行政法人理化学研究所, ボディプラン研究グループ, 上級研究員 (10264285)
Keywords	評価 / 助言 / 研究交流 / 脊椎動物 / 軸形成 / 胚葉形成 / 脳形成
Research Abstract	各計画研究を効率よく推進するため、各計画研究についての評価・助言を求め、計画研究官の連携と共同研究の促進に、本領域研究に密接に関連した研究分野から現役の第一線研究者に参加を要請して本総括班を組織した。本年度総括班会議は6月、2月の2回開催した。 1.6年7月に本領域研究の成果を問い、欧米の第一線の研究者との交流を目的に、頭部形成に関する国際会議を開催する。欧米からの参加者はJohn Rubenstein(UCSF, USA), Arturo Alvarez-Buylla(UCSF, USA), Johan Ericson(Karolinska Institute, Sweden), Alexandra Joyner(New York Univ., USA), Andrew Lumsden(King's College London, Guy's Hospital, UK), Susan McConnell(Stanford Univ., USA), Dennis O'Leary(The Salk Institute, USA), Andrew Peterson(Univ.of California at San Francisco, USA), Luis Puelles(Univ.of Murcia, Spain), Stephen Wilson(Univ.College London, UK) 2.平成13年度の魚類・両棲類、平成14年度の哺乳動物、鳥類に対し、平成15年度の領域研究会は、各種脊椎動物での頭部形成の比較発生学的考察に焦点をあて開催する。 3.平成15年度特に推進された研究交流は以下の通りである。三品祐司(NIH)、関戸良平(MRC National lnstitute for Medical Research)、松永英治(Universite Paris6)、山本正道(大阪大学)

Research Products

(12 results)

All Other

All Publications (12 results)

[Publications] Saito, T., et al.: "Notch2 is Preferentially Expressed iin Mture B Cells and Indispensable for Marginal Zone B Lineage Development."Immunity. 18. 675-685 (2003)
[Publications] Terauchi, Y., et al.: "Impact of Genetic Background and Ablation of Insulin Receptor Sustrate (IRS)-3 on IRS-2 Knock-out Mice."The Journal of Biological chemistry. 278. 14284-14290 (2003)
[Publications] Terada, K., et al.: "Expression of Tom34 Splicing Isoforms in Mouse Testus and Knockout of Tom34 in Mice."J.Biochem.. 133. 625-631 (2003)
[Publications] Wakabayashi, Y., et al.: "Bcl11b is required for differentiation and survival of α β T lymphocytes."Nature Immunology. 4. 533-539 (2003)
[Publications] UMEZU, T., et al.: "CHARACTERIZATION OF NEWLY ESTABLISHED CLONAL OVIDUCTAL CELL LINES AND DIFFERENTIAL HORMONAL REGULATION OF GENE EXPRESSION."In Vitro Cell.Dev.Biol.-Animal. 39. 146-156 (2003)
[Publications] Nishida, A., et al.: "Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development."Nature Neuroscience. 6. 1255-1263 (2003)
[Publications] Hirabayashi, Y., et al.: "Evaluation of nonthreshold leukemogenic response to methy1 nitrosourea in p53-deficienct C3H/He mice."Toxicology and Applied Pharmacology. 190. 251-261 (2003)
[Publications] Kuwahara, K.et al.: "Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses."Proc.Natl.Acad.USA.. 10. 1073-1078 (2004)
[Publications] Kimura-Yoshida, C., et al.: "Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for the vertebrate head specification."Development. 131. 57-71 (2004)
[Publications] Furukawa, T., et al.: "Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development."Nature Neurosci. (in press). (2004)
[Publications] Kurokawa, D., et al.: "Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm."Development. (in press). (2004)
[Publications] Kurokawa, D., et al.: "Regulatign of Otx2 expression and its functions in mouse forebrain and midbrain."Development. (in press). (2004)

2003 Fiscal Year Annual Research Report

頭部形成の分子機構

Principal Investigator

相沢 慎一 独立行政法人理化学研究所, ボディプラン研究グループ, グループディレクター (60073011)

Research Products

[Publications] Saito, T., et al.: "Notch2 is Preferentially Expressed iin Mture B Cells and Indispensable for Marginal Zone B Lineage Development."Immunity. 18. 675-685 (2003)

[Publications] Terauchi, Y., et al.: "Impact of Genetic Background and Ablation of Insulin Receptor Sustrate (IRS)-3 on IRS-2 Knock-out Mice."The Journal of Biological chemistry. 278. 14284-14290 (2003)

[Publications] Terada, K., et al.: "Expression of Tom34 Splicing Isoforms in Mouse Testus and Knockout of Tom34 in Mice."J.Biochem.. 133. 625-631 (2003)

[Publications] Wakabayashi, Y., et al.: "Bcl11b is required for differentiation and survival of α β T lymphocytes."Nature Immunology. 4. 533-539 (2003)

[Publications] UMEZU, T., et al.: "CHARACTERIZATION OF NEWLY ESTABLISHED CLONAL OVIDUCTAL CELL LINES AND DIFFERENTIAL HORMONAL REGULATION OF GENE EXPRESSION."In Vitro Cell.Dev.Biol.-Animal. 39. 146-156 (2003)

[Publications] Nishida, A., et al.: "Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development."Nature Neuroscience. 6. 1255-1263 (2003)

[Publications] Hirabayashi, Y., et al.: "Evaluation of nonthreshold leukemogenic response to methy1 nitrosourea in p53-deficienct C3H/He mice."Toxicology and Applied Pharmacology. 190. 251-261 (2003)

[Publications] Kuwahara, K.et al.: "Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses."Proc.Natl.Acad.USA.. 10. 1073-1078 (2004)

[Publications] Kimura-Yoshida, C., et al.: "Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for the vertebrate head specification."Development. 131. 57-71 (2004)

[Publications] Furukawa, T., et al.: "Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development."Nature Neurosci. (in press). (2004)

[Publications] Kurokawa, D., et al.: "Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm."Development. (in press). (2004)

[Publications] Kurokawa, D., et al.: "Regulatign of Otx2 expression and its functions in mouse forebrain and midbrain."Development. (in press). (2004)

相沢慎一独立行政法人理化学研究所, ボディプラン研究グループ, グループディレクター (60073011)