Immune tolerance and regulation towards understanding and cure of autoimmune disease

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 13140203
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: SAKAGUCHI Shimon Kyoto University Institute for Frontier Medical Sciences, Professor, 再生医科学研究所, 教授 (30280770)
• Co-Investigator(Kenkyū-buntansha): INABA Kayo Grad Schl. Biostudies, Dept. Animal Develop. Physiology, Professor, 生命科学研究科, 教授 (00115792) ; KIKUTANI Hitoshi Osaka University Research Institute for Microbial Diseases, Professor, 微生物研究所・分子免疫制御分野, 教授 (80161412) ; AZUYMA Miyuki Tokyo Medical and Dental University Department molecular, Immunology Professor, 大学院医歯学総合研究科, 教授 (90255654) ; HIROSE Sachiko Juntendo University School of Medcine, AssociateProfessor, 医学部, 助教授 (00127127)
• Project Period (FY): 2001 – 2006
• Keywords: Autoimmune disease / Regulatory T cell / Dendritic cells / Semaphoring / Co-stimulatory molecule / Genetic susceptibilit / Immunological self-tolerance / Foxp3

Research Abstract

The aim of this project is to elucidate the cause and the pathogenetic mechanism of autoimmune disease, and seek for effective ways of its treatment and prevention. Five researchers as principal investigators of the project conducted the following research. Shimon Sakaguchi studied the molecular and cellular basis of natural regulatory T cells and found that the transcription factor Foxp3 is a master control molecule for the development and function of regulatory T cells. Transduction of Foxp3 into normal T cells was indeed able to convert them to regulatory T cells functionally in humans and mice. Kayo Inaba showed that dendritic cells, which are a potent activator of T cell immune responses, also play a key role in induction and expansion of regulatory T cells when dendritic cells become mature. Hitoshi Kikutani characterized CD40, several semaphorin molecules, and their respective ligands, and showed their roles in controlling immune responses. He produced monoclonal antibodies specific for some of semaphoring molecules and showed that the antibodies could suppress the development of autoimmune disease in mouse models. Miyuki Azuma studied the roles of co-stimulatory molecules, in particular PD1, ICOS and GITR?, for T cell activation, and attempted to treat autoimmune disease in mouse models by raising monoclonal antibodies specific for these molecules. Sachiko Hirose conducted genetic study to identify and characterize the susceptibility genes for systemic autoimmune disease. She showed that the polymorphism of the LTK, FcgRIIB and other genes in a lupus model mouse, and confirmed the LTK polymorphism in human lupus as well.

Research Products

• [Journal Article] CD3 and IgG Fe receptor regulate cerebellar functions. (2007)
  • Author(s): Nakamura K., et al.
  • Journal Title: Mol. Cell. Biol. (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Semaphorin 7A initiates T cell-mediated inflammatory resonses through ・1・1 integrin. (2007)
  • Author(s): Suzuki, K., et al.
  • Journal Title: Nature 446 Pages: 680-684
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Immune semaphorins : Increasing members and their diverse roles. (2007)
  • Author(s): Kikutani, H., et al.
  • Journal Title: Adv. Immunol. 93 Pages: 121-143
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Multipotency of CD11b^highGr-1^+ immature myeloid cells accumulating in oral squamous cell carcinoma-bearing mice. (2007)
  • Author(s): Tanaka K, Piao J, Omura K, Azuma M.
  • Journal Title: Oral Oncology. 43 Pages: 586-592
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Over expression of B7-H1 (PD-L1) significantly associated with tumor grade and postoperative prognosis in human urothelial cancers. (2007)
  • Author(s): Nakanishi J, Wada Y, Matsumoto K, Azuma M, Kikuchi K, Ueda S.
  • Journal Title: Cancer Immunol mmunother (On line publication)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Clinical significance and therapeutic potential of the Programmed Death-1 ligand/Programmed Death-1 pathway in human pancreatic cancer. (2007)
  • Author(s): Nomi T, Sho M, Akahori T, Hamada K, Kubo A, Kanehiro H, Nakamura S, Enomoto K, Yagita H, Azuma M, Nakajima Y
  • Journal Title: Clin Cancer Res 13 Pages: 2151-2157
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] B7-1 mediated costimulation regulates pancreatic autoimmunity. (2007)
  • Author(s): Yadav D, Fine C, Azuma M, Sarvetmick N.
  • Journal Title: Mol. Immunol. 44 Pages: 2616-2624
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Involvement of the PD-1/PD-L1 pathway in CD4^+CD25^+ regulatory T-cell activity to suppress alloimmune responses. (2007)
  • Author(s): Kitazawa Y, Fujino M, Wang Q, Kimura H, Azuma M, Kubo M, Abe R, Li X.
  • Journal Title: Transplantation 83 Pages: 774-782
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Foxp3 controls regulatory T cell function via interacting with AML1/Runx1 (2007)
  • Author(s): Ono M, et al.
  • Journal Title: Nature. 8 Pages: 333-334
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Foxp3 and Aire in thymus-generated T(reg) cells : a link in self-tolerance (2007)
  • Author(s): Nomura T, et al.
  • Journal Title: Nat Immunol. 8 Pages: 333-334
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Natural regulatory T cells : mechanisms of suppression. (2007)
  • Author(s): Miyara M et al.
  • Journal Title: Trends Mol Med. 13 Pages: 108-116
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17^+ Th cells that cause autoimmune arthritis (2007)
  • Author(s): Hirota K et al.
  • Journal Title: J Exp Med 204 Pages: 1197-1209
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation. (2007)
  • Author(s): Koshiba T et al.
  • Journal Title: Transpl Immunol 17 Pages: 94-97
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulatory T cell-mediated suppression : potential role of ICER. (2007)
  • Author(s): Bodor J et al.
  • Journal Title: J Leukoc Biol. 81 Pages: 161-167
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CD3 and IgG Fc receptor regulate cerebellar functions. (2007)
  • Author(s): Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xiu Y, Ohtsuji M, Qing Shun Lin Q, Tsukamoto K, Nishimura H, Ono M, Watanabe M, Hirose S.
  • Journal Title: Mol. Cell. Biol.
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Semaphorin 7A initiates T cell-mediated inflammatory resonses through a1β1 integrin. (2007)
  • Author(s): Suzuki, K., et al.
  • Journal Title: Nature 446 Pages: 680-684
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Foxp3 controls regulatory T cell function via i nteracting with AML1/Runxl.. (2007)
  • Author(s): Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, Miyachi Y, Tsukada T, Sakaguchi S.
  • Journal Title: Nature. 446 Pages: 685-689
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Foxp3 and Aire in thymus-generated T(reg) cells : a link in self-tolerance. (2007)
  • Author(s): Nomura T, Sakaguchi S.
  • Journal Title: Nat Immunol. 8 Pages: 333-334
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Natural regulatory T cells : mechanisms of suppression. (2007)
  • Author(s): Miyara M, Sakaguchi S.
  • Journal Title: Trends Mol Med. 13 Pages: 108-116
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. (2007)
  • Author(s): Hirota K, Hashimoto M, Yoshitomi H, Tanaka S, Nomura T, Yamaguchi T, Iwakura Y, Sakaguchi N, Sakaguchi S.
  • Journal Title: J Exp Med. 204 Pages: 41-47
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] and pathological aspects of operational tolerance after pediatric living-donor liver transplantation. (2007)
  • Author(s): Koshiba T, Li Y, Takemura M, Wu Y, Sakaguchi S, Minato N, Wood KJ, Haga H, Ueda M, Uemoto S. Clinical, immunological
  • Journal Title: Transpl Immunol. 17 Pages: 94-97
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulatory T cell-mediated suppression : potential role of ICER.. (2007)
  • Author(s): Bodor J, Fehervari Z, Diamond B, Sakaguchi S.
  • Journal Title: J Leukoc Biol. 81 Pages: 161-167
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cyto plasmic autoantibody production, and renal traits in spontaneous crescentic glomerulonephritis-forming/Kinjo mice. (2006)
  • Author(s): Hamano Y., et al.
  • Journal Title: J. Immunol. 176 Pages: 3662-3673
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. (2006)
  • Author(s): Lin Q., et al.
  • Journal Title: J. Immunol. 177 Pages: 1646-1654
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Significance of MHC class II haplotypesand IgG Fe receptors in SLE. (2006)
  • Author(s): Hirose S., et al.
  • Journal Title: Springer Seminars in Immnopathol. 28 Pages: 163-174
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Molecular pathogenesis of SLE. (2006)
  • Author(s): Shirai T., et al.
  • Journal Title: Springer Seminars in Immnopathol. 28 Pages: 79-82
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Genetic control of the spontaneous activation of CD4^+ Th cells in systemic lupus erythematosus-prone (NZB × NZW) F1 mice. (2006)
  • Author(s): Fujii T., et al.
  • Journal Title: Genes Immun. 7 Pages: 647-654
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] IL-4R□ polymorphism in regulation of IL-4 synthesis by T cells : implication in susceptibility to a subset of murine lupus. (2006)
  • Author(s): Shiroiwa W., et al.
  • Journal Title: Int. Immunol. 19 Pages: 175-183
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Predominant expression of B7-H1 and its immunoregulatory roles in oral squamous cell carcinoma. (2006)
  • Author(s): Tsushima F, Tanaka K, Otsuki N, Youngnak P, Iwai H, Omura K, Azuma M.
  • Journal Title: Oral Oncol. 43(3) Pages: 268-274
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression and regulation of human CD275 on endothelial cells in healthy and inflamed mucosal tissues. (2006)
  • Author(s): Youngnak-Piboonratanakit P, Tsushima F, Otsuki N, Igarashi H, Omura K, Azuma M.
  • Journal Title: Scan. J. Immunol 63 Pages: 191-198
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential role of PD-L1 and PD-L2 in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis. (2006)
  • Author(s): Zhu B, Guleria I, Khosroshahi A, Chitnis T, Imitalo J, Azuma M, Yagita H, Sayegh MH, Khoury SJ.
  • Journal Title: J. Immunol 176 Pages: 3480-3489
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells. (2006)
  • Author(s): Otsuki N, Kamimura Y, Hashiguchi M, Azuma M.
  • Journal Title: Biochem Biophy Res Commun 344 Pages: 1121-1127
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Preferential involvement of Tim-3 in the regulation of hepatic CD8^+ T cells in murine acute graft-versus-host disease. (2006)
  • Author(s): Oikawa T, Kamimura Y, Akiba H, Yagita H, Okumura K, Takahashi H, Zeniya M, Tajiri H, Azuma M.
  • Journal Title: J. Immun 177 Pages: 4281-4287
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The existence of CD11c^+ sentinel and F4/80^+ interstitial dendritic cells in dental pulp and their dynamics and functional properties. (2006)
  • Author(s): Zhang, J, Kawashima N, Suda H, Nakano Y, Takano Y, Azuma M.
  • Journal Title: Int Immunol. 18 Pages: 1375-1384
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fundamental mechanisms of host immune responses to infection. (2006)
  • Author(s): Azuma M.
  • Journal Title: J Periodontol Res. 41 Pages: 361-373
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Involvement of programmed death-ligand 2 (PD-L1) in the development of experimenta ; allergic conjunctivitis in mice. (2006)
  • Author(s): Fukushima A, Yamaguchi T, Azuma M, Yagita H, Ueno H
  • Journal Title: Brit J. Ophthalmol. 90 Pages: 1040-1045
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] B7-H1-induced apoptos is as a mechanism of immune privilege of corneal allografts. (2006)
  • Author(s): Hori J, Wang M, Niyashita M, Tanemopto K, Takemori T, Okumura K, Yagita H, Azuma M.
  • Journal Title: J. Immunol. 177 Pages: 5928-5935
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Insulin-induced remission in new onset NOD mice is maintained by the PD-1/PD-L1 pathway. (2006)
  • Author(s): Fife BT, Guleria T, Gubbels-Bupp M, Yagita H, Azuma M, Bour-Jordan H, Sayegh MH, Bluestone JA.
  • Journal Title: J Exp Med. 203 Pages: 2737-2747
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Phagocytosis of co-developing megakaryocytic progenitors by dendritic cells in culture with thrombopoietin and tumor necrosis factor-□ and its possible role in hemophagocytic syndrome. (2006)
  • Author(s): Saito K et al.
  • Journal Title: Blood 107 Pages: 1366-1374
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effective expansion of alloantigen-specific foxp3^+ CD25^+ CD4^+ regulatory T cells by dendritic cells during the mixed leukocyte reaction. (2006)
  • Author(s): Yamazaki S et al.
  • Journal Title: Pro. Natl. Acad. Sci. USA. 103 Pages: 2758-276
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Dendritic cells expand antigen-specific Foxp3^+ CD25^+ CD4^+ regulatory T cells, including suppressors of alloreactivity. (2006)
  • Author(s): Yamazaki S et al.
  • Journal Title: Immunol. Rev. 212 Pages: 314-329
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. (2006)
  • Author(s): Takegahara, N., et al.
  • Journal Title: Nature Cell Biol. 8 Pages: 615-622
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Glucocorticoid-induced tumour necrosis factor receptor family-related receptor signalling exacerbates hapten-induced colitis by CD4+ T cells. (2006)
  • Author(s): Lee SK., et al.
  • Journal Title: Immunology 119(4) Pages: 479-87
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Skin controls immune regulators. (2006)
  • Author(s): Yamaguchi T, Sakaguchi S
  • Journal Title: Nat Med 12 Pages: 1358-1359
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Spontaneous Large-Scale Lymphoid Neogenesis and Balanced Autoimmunity versus Tolerance in the Stomach of H+/K+-ATPase-Reactive TCR Transgenic Mouse. (2006)
  • Author(s): Katakai T, et al.
  • Journal Title: J Immunol 177 Pages: 7858-67
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A role for Dicer in immune regulation. (2006)
  • Author(s): Cobb BS et al.
  • Journal Title: J Exp Med 203 Pages: 2519-1517
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Delineation of immunoregulatory properties of adult T-cell leukemia cells. (2006)
  • Author(s): Matsubara Y
  • Journal Title: Int. J. Hematol. 84 Pages: 63-69
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cytokine production profile of splenocytes derived from zymosan A-treated SKG mice developing arthritis. (2006)
  • Author(s): Kobayashi K
  • Journal Title: Inflamm Res. 55 Pages: 335-341
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulatory T cells in allergy. (2006)
  • Author(s): Wing, K
  • Journal Title: Curr. Opin. Allergy and Immunol. 6 Pages: 482-8
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Introduction : Regulatory T cells (2006)
  • Author(s): Sakaguchi, S
  • Journal Title: Springer Ssemin. Immunopathol 28 Pages: 1-2
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Peacekeepers of the immune system. (2006)
  • Author(s): Fehervari, Z.
  • Journal Title: Sci Am 295 Pages: 56-63
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Emerging possibilities in the development and function of regulatory T cells. (2006)
  • Author(s): Wing, K
  • Journal Title: Int. Immunol 18 Pages: 991-1000
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Foxp3-dependent and -independent molecules specific for CD25^+CD4^+ natural regulatory T cells revealed by DNA microarray analysis. (2006)
  • Author(s): Sugimoto, N. et al.
  • Journal Title: Int. Immunol 18 Pages: 1197-1209
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CD4^+CD25^+Foxp3^+ T cells and CD4^+CD25^-Foxp3^+ T cells in aged mice. (2006)
  • Author(s): Nishioka, T., et al.
  • Journal Title: J. Immunol 176 Pages: 6586-6593
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity. (2006)
  • Author(s): Ramirez-Montagut T, et al.
  • Journal Title: J. Immunol 176 Pages: 6434-6442
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulatory T cells : meden agan.. (2006)
  • Author(s): Sakaguchi, k S.:
  • Journal Title: Immunol. Rev 212 Pages: 5-7
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Foxp3^+CD25^+CD4^+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. (2006)
  • Author(s): Sakaguchi, S.et ai
  • Journal Title: Immunol. Rev 212 Pages: 8-27
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity (2006)
  • Author(s): Cohen AD
  • Journal Title: Cancer Res 66 Pages: 4904-4912
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Conversion of alloantigen-specific CD8+ T-cell priming through in vitro ligation of glucocorticoid-induced TNF receptor. (2006)
  • Author(s): Kim, J.et al.
  • Journal Title: J. Immunol. 176 Pages: 5223-5231
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Induction of fatal autoimmune myocarditis and other autoimmune diseases in mice by depleting Foxp3-expressing naturally arising CD4^+ regulatory T cells. (2006)
  • Author(s): Ono, M.et al.
  • Journal Title: J. Immunol., 2006. 176 Pages: 4748-4756
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulatory T cells in autoimmunity. (2006)
  • Author(s): Ono, M.et al.
  • Journal Title: Microb. Infect. (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The dichotomous roles of IL-2 : tolerance versus immunity. 27 :,2006. (2006)
  • Author(s): Fehervari, Z. et al.
  • Journal Title: Trends Immunol. 27 Pages: 109-111
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction : Part 1. (2006)
  • Author(s): Sakaguchi, S et al.
  • Journal Title: Semin. Immunol, 18 Pages: 199-206
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulatory T cells in immune surveillance and treatment of cancer. (2006)
  • Author(s): Yamaguchi, T et al.
  • Journal Title: Cancer Bio Semi 16 Pages: 115-123
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T cells. In The hereditary Basis of Rheumatic Diseases,. (2006)
  • Author(s): Sakaguchi, S et al.
  • Journal Title: Progress in Inflammation Research Basel Pages: 147-159
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Preparation of regulatory T cells in vitro, In Immunological Tolerance (2006)
  • Author(s): Nagahama, K, Sakaguchi, S
  • Journal Title: Methods and Protocols, edit. P. J. (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Naturally arising Foxp3-expressing CD25^+Cd4^+ regulatory T cells in self-tolerance and autoimmune disease. (2006)
  • Author(s): Sakaguchi, S., et al.
  • Journal Title: Curr Top Microbiol Immunol. 305 Pages: 51-66
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] REgulatory. Nature Encyclopedia of Life Sciences.,2006. (2006)
  • Author(s): Fehervari, Z
  • Journal Title: Wiley Interscience (Available at www.els.net.)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice. (2006)
  • Author(s): Kuroda N et al.
  • Journal Title: J. Immunol. 174 Pages: 1862-1870
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Genetic dissection of vasculitis, myeloperoxidase- specific antineutrophil cytoplasmic autoantibody production, and renl traits in spontaneous crescentic glomerulonephritis-forming/Kinjo mice. (2006)
  • Author(s): Hamano Y, Tsukamoto K, Abe M, Sun G, D, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Ogawara A, Tachikawa H, Nishimura H, Tokunaga K, Hirose S, Suzuki K
  • Journal Title: J. Immunol. 176 Pages: 3662-3673
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus.. (2006)
  • Author(s): Lin Q, Xiu Y, Jiang Y, Tsurui H, Nakamura K, Kodera S, Ohtsuji M, Ohtsuji N, Shiroiwa W, Tsukamoto K, Amano H, Amano E, Kinoshita K, Sudo K, Nishimura H, Izui S, Shirai T, Hirose S.
  • Journal Title: J. Immunol. 177 Pages: 1646-1654
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Significance of MHC class II haplotypesand IgG Fc receptors in SLE. (2006)
  • Author(s): Hirose S, Jiang Y, Nishimura H, Shirai T.
  • Journal Title: Springer Seminars in Immnopathol. 28 Pages: 163-174
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular pathogenesis of SLE. (2006)
  • Author(s): Shirai T, Hirose S.
  • Journal Title: Springer Seminars in Immunopathology 28 Pages: 79-82
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• [Journal Article] Genetic control of the spontaneous activation of CD4+ Th cells in systemic lupus erythematosus-prone (NZB x NZW) Fl mice.. (2006)
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• [Journal Article] IL-4Rα polymorphism in regulation of IL-4 synthesis by T cells : implication in susceptibility to a subset of murine lupus. (2006)
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• [Journal Article] Phagocytosis of co-developing megakaryocytic progenitors by dendritic cells in culture with thrombopoietin and tumor necrosis factor-a and its possible role in hemophagocytic syndrome. (2006)
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  • Journal Title: Blood 107(4) Pages: 1366-1374
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• [Journal Article] Effective expansion of alloantigen-specific foxp3+ CD25+ 2758-2763, CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction. (2006)
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• [Journal Article] Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells, including suppressors of alloreactivity. (2006)
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• [Journal Article] Plexin-Al and its interaction with DAP12 in immune responses and bone homeostasis. (2006)
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  • Journal Title: Nature Cell Biol. 8 Pages: 615-622
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• [Journal Article] Glucocorticoid-induced tumour necrosis factor receptor family-related receptor signalling exacerbates hapten-induced colitis by CD4+ T cells.. (2006)
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  • Journal Title: Immunology. 119(4) Pages: 479-87
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• [Journal Article] Sakaguchi S. Skin controls immune regulators. (2006)
  • Author(s): Yamaguchi T
  • Journal Title: Nat Med. 12 Pages: 1358-1359
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• [Journal Article] Spontaneous Large-Scale Lymphoid Neogenesis and Balanced Autoimmunity versus Tolerance in the Stomach of H+/K+ -ATPase-Reactive TCR Transgenic Mouse.. (2006)
  • Author(s): Katakai T, Nomura T, Gonda H, Sugai M, Agata Y, Nishio A, Masuda T, Sakaguchi S, Shimizu A.
  • Journal Title: Jlmmunol. 177 Pages: 7858-67
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• [Journal Article] A role for Dicer in immune regulation. (2006)
  • Author(s): Cobb BS, Hertweck A, Smith J, O'connor E, Graf D, Cook T, Smale ST, Sakaguchi S, Livesey FJ, Fisher AG, Merkenschlager M.
  • Journal Title: J Exp Med. 203 Pages: 2519-2527
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• [Journal Article] Delineation of immunoregulatory properties of adult T-cell leukemia cells.. (2006)
  • Author(s): Matsubara Y, Hori T, Morita R, Sakaguchi S, Uchiyama T.
  • Journal Title: Int. J. Hematol. 84 Pages: 63-69
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulatory T cells in allergy. 6 : 482-8, 2006. (2006)
  • Author(s): Wing, K., Sakaguchi, S.
  • Journal Title: Cum Opin. Allergy and Immunol. 55 Pages: 335-341
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• [Journal Article] Peacekeepers of the immune system. (2006)
  • Author(s): Fehervari, Z., Sakaguchi, S.
  • Journal Title: Sci Am. 259 Pages: 56-63
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• [Journal Article] Emerging possibilities in the development and function of regulatory T cells. (2006)
  • Author(s): Wing, K., Fehervari, Z., Sakaguchi, S.
  • Journal Title: Int. Immunol. 18 Pages: 991-1000
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• [Journal Article] Foxp3-dependent and-independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis.. (2006)
  • Author(s): Sugimoto, N., Oida, T., Hirota, K., Nakamura, K., Nomura, T., Uchiyama, T., Sakaguchi.S.
  • Journal Title: Mt. Immunol. 18 Pages: 1197-1209
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• [Journal Article] CD4+CD25+ Foxp3+ T cells and CD4+CD25-Foxp3+ T cells in aged mice.. (2006)
  • Author(s): Nishioka, T., Shimizu, J, Iida, R., Yamazaki, S., Sakaguchi, S.
  • Journal Title: J. Immunol. 176 Pages: 6586-6593
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• [Journal Article] van den Brink MR. Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity.. (2006)
  • Author(s): Ramirez-Montagut T, Chow A, Hirschhom-Cymerman D, Terwey TH, Kochman AA, Lu S, Miles RC, Sakaguchi S, Houghton AN
  • Journal Title: J Immunol. 176 Pages: 6434-6442
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• [Journal Article] Regulatory T cells : meden agan. (2006)
  • Author(s): Sakaguchi. S.
  • Journal Title: Immunol. Rev. 212 Pages: 5-7
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• [Journal Article] Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease.. (2006)
  • Author(s): Sakaguchi, S., Ono, M., Setoguchi, R., Hori, S., Fehervari, Z., Shimizu, J., Takahashi, T., Nomura, T.
  • Journal Title: Immunol. Rev. 212 Pages: 8-27
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• [Journal Article] Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity.. (2006)
  • Author(s): Cohen AD, Diab A, Perales MA, Wolchok JD, Rizzuto G, Merghoub T, Huggins D, Liu C, Turk MJ, Restifo NP, Sakaguchi S, Houghton AN.
  • Journal Title: Cancer Res. 66 Pages: 4904-4912
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• [Journal Article] Conversion of alloantigen-specific CD8+ T-cell priming through in vitro ligation of glucocorticoid-induced TNF receptor.. (2006)
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  • Journal Title: J. Immunol. 176 Pages: 5223-5231
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Induction of fatal autoimmune myocarditis and other autoimmune diseases in mice by depleting Foxp3-expressing naturally arising CD4+ regulatory T cells.. (2006)
  • Author(s): Ono, M., Shimizu, J., Miyachi, Y., Sakaguchi, S.
  • Journal Title: J. Immunol. 176 Pages: 4748-4756
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• [Journal Article] The dichotomous roles of IL-2 : tolerance versus immunity. (2006)
  • Author(s): Fehervari, Z., Yamaguchi, T., Sakaguchi, S.
  • Journal Title: Trends Immunol. 27 Pages: 109-111
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• [Journal Article] Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction : Part 1. (2006)
  • Author(s): Sakaguchi, S., Sakaguchi, N., Yoshitomi, H., Hata, H., Takahashi, T., Nomura, T.
  • Journal Title: Semin. Immunol. 18 Pages: 199-206
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulatory T cells in immune surveillance and treatment of cancer. Semin.. (2006)
  • Author(s): Yamaguchi, T., Sakaguchi, S.
  • Journal Title: Cancer Biol. 16 Pages: 115-123
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 「研究成果報告書概要(欧文)」より (2006)
  • Author(s): Sakaguchi, S., Takahashi, T., Hata, H., Yoshitomi, H., Tanaka, S., Hirota, K.
  • Journal Title: Birkhaeuser Verlag, Basel Pages: 147-159
• [Journal Article] T lymphocytes : Regulatory. (2006)
  • Author(s): Fehervari, Z., Sakaguchi, S.
  • Journal Title: Nature Encyclopedia of Life Sciences. Wiley Interscience
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The FERM domain containing GEF protein FARP2 triggers signals for Sema3A-mediated axonal repulsion. (2005)
  • Author(s): Toyofuku, T., et al.
  • Journal Title: Nature Neurosci 8 Pages: 1712-1719
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• [Journal Article] Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment. (2005)
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  • Journal Title: Int. Immunol. 17 Pages: 1277-1282
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• [Journal Article] Non-redundant roles of Sema4A in the immune system : Defective T-cell priming and Th1/Th2 regulation in sema4A-deficient mice. (2005)
  • Author(s): Kumanogoh, A., et al.
  • Journal Title: Immunity 22 Pages: 305-316
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Genome-wide scan in novel IgA nephropathy model identifies susceptibility locus on murine chromosome 10, in a region sytenic to human IGAN1 on chromosome 6q22-23. (2005)
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  • Journal Title: J. Am. Soc. Nephrol. 16 Pages: 1289-1299
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• [Journal Article] Chromosomal mapping of a quantitative trait locus for the development of albuminuria in diabetic KK/Ta mice. (2005)
  • Author(s): Shike T., et al.
  • Journal Title: Nephrol. Dial. Transplant. 20 Pages: 879-885
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fas ligand and TNF-related apoptosis-inducing ligand induction on infiltrating lymphocytes in bladder carcinoma by bacillus Calmette-Guerin treatment. (2005)
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  • Journal Title: Urol. Int. 75 Pages: 80-87
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• [Journal Article] Polymorphism of the mouse gene for the interleukin 10 receptor alpha chain (IIIOra) and its association with the autoimmune phenotype. (2005)
  • Author(s): QI Z., et al.
  • Journal Title: Immunogenetics 57 Pages: 697-702
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Correlation of aggression with serum IgM level in autoimmune-prone NZB mice. (2005)
  • Author(s): Nakamura K., et al.
  • Journal Title: Dev. Brain Res. 159 Pages: 145-148
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• [Journal Article] Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. (2005)
  • Author(s): Sandner SE, Clarkson MR, Salam AD, Sanchez-Fueyo A, Domenig C, Najafian N, Yagita H, Azuma M, Turka LA, Sayegh MH.
  • Journal Title: J. Immunol 174 Pages: 3408-3415
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• [Journal Article] Clinical significance of PD-L1 and PD-L2 expression in human esophageal cancer. (2005)
  • Author(s): Ohigashi Y, Sho M, Yamada Y, Hamada K, Ikeda N, Mizuno T, Yoriki R, Tsurui Y, Kashizuka H, Yane K, Tsushima F, Otsuki N, Yagita H, Azuma M, Nakajima Y.
  • Journal Title: Clin. Cancer Res 11(8) Pages: 2947-2953
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• [Journal Article] Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA. (2005)
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  • Journal Title: Biochem Biophys Res Commun 330 Pages: 263-270
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• [Journal Article] Subcutaneous injection of a TNF-a antagonist peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis. (2005)
  • Author(s): Kojima T, Aoki K, Nonaka K, Saito H, Azuma M, Iwai H, Varghese BJ., Yoshimatsu H., Baron R, Ohya K, Amagasa T.
  • Journal Title: J. Med. Dent. Sci 52 Pages: 91-99
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• [Journal Article] Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo. (2005)
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  • Journal Title: J. Immunol 174 Pages: 6648-6656
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• [Journal Article] A critical role for the programmed death ligand 1 in fetomaternal tolerance. (2005)
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  • Journal Title: J. Exp. Med 202 Pages: 231-237
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• [Journal Article] Blockade of B7-H1 on macrophages suppresses CD4^+ T cell proliferation by augmenting IFN-〓-induced nitric oxide production. (2005)
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• [Journal Article] Antigen recognition and presentation by DC. (2005)
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• [Journal Article] Engagement of human monocyte-derived dendritic cells into interleukin (IL)-12 producer by IL-1〓〓+ IFN-〓 (2005)
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• [Journal Article] Expression and its regulation of a polymorphic inhibitory NK receptor Ly49Q on dendritic cells subsets. (2005)
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• [Journal Article] Development of murine plasmacytoid dendritic cells defined by increased expression of an inhibitory NK receptor, Ly49Q. (2005)
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• [Journal Article] Association of SIGNR1 with TLR4/MD-2 enhances signal transduction by ecognition of LPS in Gram-negative bacteria. (2005)
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• [Journal Article] Autoimmunity.. (2005)
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  • Journal Title: Curr Opin Immunol 17 Pages: 567-569
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• [Journal Article] Animal models of arthritis caused by systemic alteration of the immune system.. (2005)
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  • Journal Title: Curr Opin Immunol 17 Pages: 589-594
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• [Journal Article] The roles of CD25^+CD4^+ regulatory T cells in operational tolerance after living donor liver transplantation.. (2005)
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  • Journal Title: Transplant. Proc., 2005 37 Pages: 37-39
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• [Journal Article] Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3^+CD25^+CD4^+ regulatory T cells. (2005)
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• [Journal Article] Definition of target antigens for naturally occurring CD4^+CD25^+ regulatory T cells. (2005)
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  • Journal Title: J. Exp. Med. 201 Pages: 681-686
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• [Journal Article] Regulatory T cells, derived from naive CD4^+CD25^- T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance (2005)
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  • Journal Title: Transplantation 79 Pages: 1310-1316
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• [Journal Article] Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance : the interplay of clonal anergy and immune regulation.. : (2005)
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  • Journal Title: J. Immunol 175 Pages: 771-779
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• [Journal Article] History of CD25^+CD4^+ regulatory T cells. In Regulatory T cells in inflammation,. (2005)
  • Author(s): Sakaguchi, S., Sakaguchi, N
  • Journal Title: Progress in Inflammation Research Basel Pages: 3-17
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• [Journal Article] Regulatory T cells in tumor immunity.. (2005)
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  • Journal Title: Curr Top Microbiol Immunol 293 Pages: 287-302
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• [Journal Article] Preface : Regulatory T cells in autoimmune diseases.. (2005)
  • Author(s): Sakaguchi, S
  • Journal Title: Int. Rev. Immunol 24 Pages: 157-158
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• [Journal Article] Regulatory T cells in immunologic self-tolerance and autoimmune diseases. (2005)
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  • Journal Title: Int. Rev. Immunol 24 Pages: 211-226
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• [Journal Article] CD4^+ regulatory cells as a potential immunotherapy. (2005)
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  • Journal Title: Philos Trans R Soc Lond B Biol Sci 360 Pages: 1647-1661
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• [Journal Article] Naturally arising Foxp3-expressing CD25^+CD4^+ regulatory T cells in immunological tolerance to self and non-self. (2005)
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  • Journal Title: Nat. Immunol 6 Pages: 345-352
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• [Journal Article] Phenotypic and functional relationship between adult T cell leukemia and regulatory T cells. (2005)
  • Author(s): Matsubara, Y et al.
  • Journal Title: Leukemia 19 Pages: 482-483
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• [Journal Article] Homeostatic maintenance of natural Foxp3^+ CD25^+ CD4^+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization (2005)
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  • Journal Title: J. Exp. Med. 201 Pages: 723-735
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• [Journal Article] Environmental stimulation of innate immunity triggers chronic arthritis in mice genetically prone to produce arthritogenic autoimmune T cells : a key role of fungal 〓-glucans and their receptor Dectin-1. (2005)
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• [Journal Article] Regulatory T cells. (2005)
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  • Journal Title: Measuring Immunity, (In eds. Elsevier.) Pages: 322-335
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• [Journal Article] Contact-mediated suppression by CD4^+CD25^+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. :, (2005)
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• [Journal Article] Chromosomal mapping of a quantitative trait locus for the development of albunuria in diabetic KK/Ta mice. (2005)
  • Author(s): Shike T, Gohda T, Tanimoto M, Kobayashi M, Makita Y, Funabiki K, Horikoshi, Hirose S, Shirai T, Tomino Y
  • Journal Title: Nephrol Dial. Transplant. 20 Pages: 879-885
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fas ligand and TNF-related apoptosis-inducing ligand induction on infiltrating lymphocytes in bladder carcinoma by bacillus Calmette-Guerin treatment. (2005)
  • Author(s): Mehmut M, Takeda K, Abe M., Ogara H, Hirose S, Okumura K, Fujime M
  • Journal Title: Urol. Int. 75 Pages: 80-87
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Polymorphism of the mouse gene for the interleukin 10 receptor alpha chain (Il10ra) and its association with the autoimmune phenotype.. (2005)
  • Author(s): QI Z, Wang J, Sun Z, Ma F, Zhang Q, Hirose S, Jiang Y
  • Journal Title: Immunogenetics 57 Pages: 697-702
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Correlation of aggression with serum IgM level in autoimmune-prone NZB mice.. (2005)
  • Author(s): Nakamura K, Nishimura H, Hirose S
  • Journal Title: Dev. Brain Res. 159 Pages: 145-148
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression and its regulation of a polymorphic inhibitory NK receptor Ly49Q on dendritic cells subsets. (2005)
  • Author(s): Toyama-Sorimachi N et al.
  • Journal Title: J Immunol. 174 Pages: 4621-4629
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The FERM domain containing GEF protein FARP2 triggers signals for Sema3A-mediated axonal repulsion. (2005)
  • Author(s): Toyofuku, T., J.Yoshida, T.Sugimoto, H.Zhang, A.Kumanogoh, M.Hori, H.Kikutani.
  • Journal Title: Nature Neurosci. 8 Pages: 1712-1719
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• [Journal Article] Non-redundant roles of Sema4A in the immune system : Defective T-cell priming and Thl/Th2 regulation in sema4A-deficient mice. (2005)
  • Author(s): Kumanogoh, A., et al.
  • Journal Title: Immunity 22 Pages: 305-316
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• [Journal Article] Sakaguchi, S. Autoimmunity. (2005)
  • Author(s): Bach, J. F.
  • Journal Title: Curr Opin Immunol. 17 Pages: 567-569
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Animal models of arthritis caused by systemic alteration of the immune system. (2005)
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• [Journal Article] The roles of CD25+CD4+ regulatory T cells in operational tolerance after living donor liver transplantation. (2005)
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  • Journal Title: Transplant. Proc. 37 Pages: 37-39
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• [Journal Article] derived from naive CD4+CD25-T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance.. (2005)
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• [Journal Article] Preface : Regulatory T cells in autoimmune diseases. (2005)
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• [Journal Article] Regulatory T cells in immunologic self-tolerance and autoimmune diseases.. (2005)
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• [Journal Article] CD4+ regulatory cells as a potential immunotherapy. Philos Trans R Soc Lond B (2005)
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• [Journal Article] Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. (2005)
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  • Journal Title: Leukemia 19 Pages: 482-483
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• [Journal Article] Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. (2005)
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• [Journal Article] Environmental stimulation of innate immunity triggers chronic arthritis in mice genetically prone to produce arthritogenic autoimmune T cells : a key role of fungal 13-glucans and their receptor Dectin-1 (2005)
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• [Journal Article] Regulatory T cells. In Measuring Immunity (2005)
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• [Journal Article] Cutting Edge : Contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism.. (2005)
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• [Journal Article] Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination. (2004)
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• [Journal Article] Costimulation via glucocorticoid-induced tumor necrosis factor receptor (GITR) in both conventional and CD25^+ regulatory CD4^+ T cells. (2004)
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• [Journal Article] Ly49Q, a novel member of Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture. (2004)
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• [Journal Article] Regulatory T cells in tumor immunity. In Cancer Immunotherapy, edit. K. Toyoshima, J. C. Barrett, E. Klein, Y. Hashimoto, and H. Wakasugi., (2004)
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• [Journal Article] Regulatory T cells in tumor immunity. In Cancer Immunotherapy, edit. K. Toyoshima, J. C. Barrett, E. Klein, Y. Hashimoto, and H. Wakasugi. (2004)
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• [Journal Article] Regulation of autoimmune diabetes by non-islet-specific T cells-a role for the glucocorticoid-induced TNF receptor. (2004)
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• [Journal Article] A crucial role of IL-2 in the homeostatic maintenance of CD25^+CD4^+ regulatory T cells. (2003)
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• [Journal Article] Prostaglandin E_2-EP4 signaling is critically involved in migration and maturation of Langerhans cells in the initiation phase of contact hypersensitivity. (2003)
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• [Journal Article] Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. (2003)
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• [Journal Article] A monoclonal antibody to the 〓2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model. (2003)
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• [Journal Article] Spontaneous increase of plasma-like cells with high GAMP expression in the extrafollicular region of lymphoid organs of autoimmune-prone mice. (2003)
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• [Journal Article] A monoclonal antibody to the a2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model. (2003)
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• [Journal Article] Prostaglandin E2-EP4 signaling is critically involved in migration and maturation of Langerhans cells in the initiation phase of contact hypersensitivity. (2003)
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• [Journal Article] Reactivity of anti-PCNA murine monoclonal antibodies and human autoantibodies to the PCNA multiprotein complexes involved in cell proliferation. (2001)
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• [Journal Article] Susceptibility and negative epistatic loci contributing to type 2 diabetes mellitus and related phenotypes in a KK/Ta mouse model. (2001)
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• [Journal Article] Polymorphism and chromosomal mapping of the murine gene for B cell activating factor belonging to the TNF family (BAFF) and association with the autoimmune phenotype. (2001)
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• [Journal Article] Regulation of myeloid and lymphoid dendritic cell functions by interferons and relevant cytokines. (2001)
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• [Journal Article] Skin antigens in steady state are trafficked to regional lymph nodes by transforming growth factor-01-dependent cells. (2001)
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• [Journal Article] Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. (2001)
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• [Journal Article] Five mouse homologues of the human dendritic cell C-type Lectin, DC-SIGN (2001)
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• [Journal Article] Increased T-cell autoreactivity in the absence of CD4O-CD40 ligand interactions : A role of CD40 in regulatory T cell development. (2001)
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• [Journal Article] a monogenic model of autoimmune arthritis due to altered signal transduction in T cells. In The hereditary Basis of Rheumatic Diseases, Progress in Inflammation Research. Edited by Rikard Holmdahl,.
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• [Journal Article] Gain-of-function polymorphism in mouse and human Ltk : implications for the pathogenesis of systemic lupus erythematosus.
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• [Journal Article] Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease, but increases the risk of B-cell chronic lymphocytic leukemia in a model of murine lupus.
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