2004 Fiscal Year Final Research Report Summary
Identification of genetic factors responsible for the pathogenesis of essential hypertension
| Project/Area Number |
13204050
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | OSAKA UNIVERSITY |
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Principal Investigator |
OGIHARA Toshio Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (60107042)
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| Co-Investigator(Kenkyū-buntansha) |
KATSUYA Tomohiro Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (30311757)
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| Project Period (FY) |
2001 – 2004
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| Keywords | gene polymorphism / disease susceptibility / cardiovascular disease / personalized medicine / hypertension / gene environmental interaction / salt sensitivity / obesity |
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| Research Abstract |
Essential hypertension is major risk for cardiovascular disease and its cause is still unknown. Though the gene environmental interaction is important in the pathogenesis of essential hypertension, the precise mechanism of the interaction has not been elucidated yet. To demonstrate the whole genome scan, we provided a lot of number of human DNA samples (n>10,000) to Hypertension Task Force of Japanese Millennium Genome Project, resulted that several new candidate genes were identified. Using the candidate gene approach, we carried out Handai Study and several large genetic epidemiological studies (S, O, A, TS), resulted that we also revealed several gene-environmental interactions. First of all, we pointed out the high frequency of salt sensitive alleles in Japanese than Caucasians according to the comparison in the allele frequency of AGT, ADD1, GNB3, CYP11B2 gene polymorphisms. A genetic polymorphism of thiazide sensitive NaCl cotransporter gene, in which mutation was denoted as the genetic cause of Gitelman's syndrome, was also associated with the prevalence of essential hypertension only in females. In addition, MTHFR polymorphism increased the risk for carotid atherosclerosis in the females with smoking habit, and ADRB2and ET1 gene polymorphisms were significantly associated with high prevalence of essential hypertension with obesity. The obtained results suggested the importance of personalized medication or life style modification according to the difference of their gene polymorphism.
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[Journal Article] Hypoadiponectinemia is an independent risk factor for hypertension2004
Author(s)
Iwashima Y, Katsuya T, Ishikawa K, Ouchi N, Ohishi M, Sugimoto K, Fu Y, Motone M, Yamamoto K, Matsuo A, Ohashi K, Kihara S, Funahashi T, Rakugi H, Matsuzawa Y, Ogihara T
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Journal Title
Hypertension 43
Pages: 1318-1323
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Alpha-Adducin Gly460Trp polymorphism is associated with low renin hypertension in younger subjects in the Ohasama study2002
Author(s)
Sugimoto K, Hozawa A, Katsuya T, Matsubara M, Ohkubo T, Tsuji I, Motone M, Higaki J, Hisamachi S, Imai Y, Ogihara T
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Journal Title
J Hypertens 20
Pages: 1779-1784
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects : the Suita Study2002
Author(s)
Katsuya T, Baba S, Ishikawa K, Mannami T, Fu Y, Inamoto N, Asai T, Fukuda M, Higaki J, Ogata J, Ogihara T
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Journal Title
J Hypertens 20
Pages: 2017-2021
Description
「研究成果報告書概要(和文)」より
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