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2004 Fiscal Year Final Research Report Summary

Identification of genetic factors responsible for the pathogenesis of essential hypertension

Research Project

Project/Area Number 13204050
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOSAKA UNIVERSITY

Principal Investigator

OGIHARA Toshio  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (60107042)

Co-Investigator(Kenkyū-buntansha) KATSUYA Tomohiro  Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (30311757)
Project Period (FY) 2001 – 2004
Keywordsgene polymorphism / disease susceptibility / cardiovascular disease / personalized medicine / hypertension / gene environmental interaction / salt sensitivity / obesity
Research Abstract

Essential hypertension is major risk for cardiovascular disease and its cause is still unknown. Though the gene environmental interaction is important in the pathogenesis of essential hypertension, the precise mechanism of the interaction has not been elucidated yet. To demonstrate the whole genome scan, we provided a lot of number of human DNA samples (n>10,000) to Hypertension Task Force of Japanese Millennium Genome Project, resulted that several new candidate genes were identified. Using the candidate gene approach, we carried out Handai Study and several large genetic epidemiological studies (S, O, A, TS), resulted that we also revealed several gene-environmental interactions. First of all, we pointed out the high frequency of salt sensitive alleles in Japanese than Caucasians according to the comparison in the allele frequency of AGT, ADD1, GNB3, CYP11B2 gene polymorphisms. A genetic polymorphism of thiazide sensitive NaCl cotransporter gene, in which mutation was denoted as the genetic cause of Gitelman's syndrome, was also associated with the prevalence of essential hypertension only in females. In addition, MTHFR polymorphism increased the risk for carotid atherosclerosis in the females with smoking habit, and ADRB2and ET1 gene polymorphisms were significantly associated with high prevalence of essential hypertension with obesity. The obtained results suggested the importance of personalized medication or life style modification according to the difference of their gene polymorphism.

  • Research Products

    (14 results)

All 2005 2004 2003 2002

All Journal Article (12 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Beta2- and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years2005

    • Author(s)
      Masuo K, Katsuya T, Fu Y, Rakugi H, Ogihara T, Tuck ML
    • Journal Title

      Circulation 111

      Pages: 3429-3434

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Beta2-and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years.2005

    • Author(s)
      Masuo A, Katsuya T, Ogihara T, et al.
    • Journal Title

      Circulation 111

      Pages: 3429-34

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women.2004

    • Author(s)
      Matsuo A, Katsuya T, Ishikawa K, Sugimoto K, Iwashima Y, Yamamoto K, Ohishi M, Rakugi H, Ogihara T
    • Journal Title

      J Hypertens 22

      Pages: 2123-2127

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Hypoadiponectinemia is an independent risk factor for hypertension2004

    • Author(s)
      Iwashima Y, Katsuya T, Ishikawa K, Ouchi N, Ohishi M, Sugimoto K, Fu Y, Motone M, Yamamoto K, Matsuo A, Ohashi K, Kihara S, Funahashi T, Rakugi H, Matsuzawa Y, Ogihara T
    • Journal Title

      Hypertension 43

      Pages: 1318-1323

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] G2736A polymorphism of thiazide-sensitive Na-C1 cotransporter gene predisposes to hypertension in young women.2004

    • Author(s)
      Masuo K, Katsuya T, Ogihara T, et al.
    • Journal Title

      J Hypertens 22

      Pages: 2123-7

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Hypoadiponectinemia is an independent risk factor for hypertension2004

    • Author(s)
      Iwashima Y, Katsuya T, Ogihara T, et al.
    • Journal Title

      Hypertension 43

      Pages: 1318-23

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association of methylenetetrabydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population2003

    • Author(s)
      Inamoto N, Katsuya T, Kokubo Y, Mannami T, Asai T, Baba S, Ogata J, Tomoike H, Ogihara T
    • Journal Title

      Stroke 34

      Pages: 1628-1633

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population.2003

    • Author(s)
      Inamoto N, Katsuya T, Ogihara T, et al.
    • Journal Title

      Stroke 34

      Pages: 1628-33

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Alpha-Adducin Gly460Trp polymorphism is associated with low renin hypertension in younger subjects in the Ohasama study2002

    • Author(s)
      Sugimoto K, Hozawa A, Katsuya T, Matsubara M, Ohkubo T, Tsuji I, Motone M, Higaki J, Hisamachi S, Imai Y, Ogihara T
    • Journal Title

      J Hypertens 20

      Pages: 1779-1784

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects : the Suita Study2002

    • Author(s)
      Katsuya T, Baba S, Ishikawa K, Mannami T, Fu Y, Inamoto N, Asai T, Fukuda M, Higaki J, Ogata J, Ogihara T
    • Journal Title

      J Hypertens 20

      Pages: 2017-2021

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Alpha-Adducin Gly460Trp polymorphism is associated with low rennin hypertension in younger subjects in the Ohasama study.2002

    • Author(s)
      Sugimoto K, Katsuya T, Ogihara T, et al.
    • Journal Title

      J Hypertens 20

      Pages: 1779-84

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects : the Suita Study.2002

    • Author(s)
      Katsuya T, Ogihara T, et al.
    • Journal Title

      JHypertens 20

      Pages: 2017-21

    • Description
      「研究成果報告書概要(欧文)」より
  • [Patent(Industrial Property Rights)] アシジオテンシン変換酵素遺伝子の挿入/欠失多型の効率的タイピング方法2004

    • Inventor(s)
      勝谷友宏, 杉本研, 赤坂憲, 荻原俊男
    • Industrial Property Rights Holder
      勝谷友宏, 杉本研, 赤坂憲, 荻原俊男
    • Industrial Property Number
      特願2004-119417号
    • Filing Date
      2004-04-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] エンドセリン1遺伝子中の多型を利用した高血圧症の遺伝子診断およびこれに用いるための核酸分子2002

    • Inventor(s)
      荻原俊男, 河野雄平, 万波俊文, 宮田敏行, 友池仁暢
    • Industrial Property Rights Holder
      荻原俊男, 河野雄平, 万波俊文, 宮田敏行, 友池仁暢
    • Industrial Property Number
      特願2002-263015号
    • Filing Date
      2002-09-09
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2008-05-27  

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