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2002 Fiscal Year Final Research Report Summary

Development of a quick diagnosis of Haemophilus influenzea Which induces Guillain- Barre syndrome.

Research Project

Project/Area Number 13307010
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionCHIBA UNIVERSITY

Principal Investigator

NODA Masatoshi  CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学研究院, 教授 (60164703)

Co-Investigator(Kenkyū-buntansha) YAHIRO Kinnosuke  CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSISTANT, 大学院・医学研究院, 助手 (80345024)
KUWABARA Satoshi  CHIBA UNIVERSITY, UNIVERSITY HOSPITAL LECTURER, 医学部付属病院, 講師 (70282481)
MORINAGA Naoko  CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 大学院・医学研究院, 助教授 (20092108)
Project Period (FY) 2001 – 2002
KeywordsGuillain-Barre syndrome / Haemophilus influenza / Ganalioside GM1 / ganglioside GM1-like structure / cytotoxin
Research Abstract

It has been reported recently that Haemophilus influenzas can elicit an axonal form of Guillain-Barre syndrome. It is very important to know which Haemophilus influenzas can induce the Guillain-Barre syndrome. Group A of Haemophilus influenzae which were isolated from patients with Guillain-Barre syndrome were characterized and compared with Group B of Haemophilus influenzae which were isolated from patients without Guillain-Barre syndrome. It is concluded that Haemophilus influenzae in Group A has a ganglioside GM1-like structure and a cytotoxin whose molecular weight is approximately 40,000. The ganglioside GM1-like structure and the cytotoxin may be the most important characters of Haemophilus influenzae which can induce the Guillain-Barre syndrome. By using these two characters we are now developing a quick diagnosis of Haemophilus influenzae which can induce the Guillain-Barre syndrome.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Kuwabara S., et al.: "Differences in membrane properties of axonal and demyelinating Guillain-Barre syndromes"Ann Neurol. 52. 180-187 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuwabara S., et al.: "Hyperreflexia in axonal Guillain-Barre syndrome subsequent to Campylobacter jejuni enteritis"J Neurol Sci.. 199. 89-92 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Asahina M, Kuwabara S., et al.: "Autonomic function in demyelinating and axonal subtypes of Guillain-Barre syndrome"Acta Neurol Scand.. 105. 44-50 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki K, Kuwabara S, et al.: "Fine specificities of anti-LM1 IgG antibodies in Guillain-Barre syndrome"J Neurol Sci.. 195. 145-148 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuwabara S., et al.: "Unilateral cranial and phrenic nerve involvement in axonal Guillain-Barre syndrome"Muscle Nerve. 25. 297-299 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuwabara S., et al.: "Indicators of rapid clinical recovery in Guillan-Barre syndrome"J Neurol Neurosurg Psychiatry. 70. 560-562 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuwabara S., et al.: "Differences in membrane proteins of axonal and demyelinating Guillain-Barre syndromes"Ann Neurol. 52. 180-187 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuwabara S. et al.: "Hyperreflexia in axonal Guillain-Bane syndrome subsequent to Campylobacter jejuni enteritis"J Neurol Sci. 199. 89-92 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asahina M, Kuwabara S. et al.: "Autonomic function in demyelinating and axonal subtypes of Guillain-Barre syndrome"Acta Neurol Scand. 105. 44-50 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki K, kuwabara S. et al.: "Fine specificities of anti-LM1 IgG antibodies in Guillain Barre syndrome"J Neurol Sci. 195. 145-148 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuwabara S. et al.: "Unilateral cranial and phrenic nerve involvement in axonal Guillain-Barre syndrome"Muscle Nerve. 25. 297-299 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuwabara S. et al.: "Indicators of rapid clinical recovery in Gillain-Barre syndrome"J Neurosurg Psychiatry. 70. 560-562 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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