2002 Fiscal Year Final Research Report Summary
Transcriptome Analysis of Atherosclerosis
| Project/Area Number |
13307023
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KODAMA Tatsuhiko Research Center for Advanced Science and Technology, Professor, 先端科学技術研究センター, 科学技術振興特任教員(常勤形態) (90170266)
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| Co-Investigator(Kenkyū-buntansha) |
WADA Yoichiro Komaba Open Laboratory, Research Assistant, 駒場オープンラボラトリー, 助手 (10322033)
DOI Takefumi Osaka University, Graduate school of Pharmaceutical, Professor, 大学院・薬学研究科, 教授 (00211409)
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| Project Period (FY) |
2001 – 2002
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| Keywords | DNA microarray / Atherosclerosis / transcription factor / GATA / WTAP / NFATc |
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| Research Abstract |
The changes in gene expression profiles during atherogenesis in vascular wall cells including vascular endothelial cell, vascular smooth muscle cell, monocyte and macrophage were studied using oligonucleotide DNA microarray. Following three targets were mainly analyzed comprehensively.
(1)Molecular mechanism of monocyte/endothelial cell interaction :
(2)Molecular mechanism of lipid accumulation in vascular smooth muscle cell :
(3)Transcriptome analysis of monocyte macrophage differentiation :
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[Publications] Takayanagi H, Kim S, Koga T.Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T.: "Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts"Dev Cell.. 3(6). 889-901 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Tanaka T, Takeno T, Watanabe Y, Uchiyama Y, Murakami T, Yamashita H, Suzuki A, Aoi R, Iwanari H, Jiang SY, Naito M, Tachibana K, Doi T, Shulman AI, Mangelsdorf DJ, Reiter R, Auwerx J, Hamakubo T, Kodama T.: "The Generation of Monoclonal Antibodies against Human Peroxisome Proliferator-activated Receptors (PPARs)"J Atheroscler Thromb.. 9(2). 233-242 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T.: "Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts"Dev Cell.. 3(6). 889-901 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Tanaka T, Takeno T, Watanabe Y, Uchiyama Y, Murakami T, Yamashita H, Suzuki A, Aoi R, Iwanari H, Jiang SY, Naito M, Tachibana K, Doi T, Shulman Al, Mangelsdorf DJ, Reiter R, Auwerx J, Hamakubo T,Kodama T.: "The Generation of Monoclonal Antibodies against Human Peroxisome Proliferator-activated Receptors(PPARs)"J Atheroscler Thromb.. 9. 233-242 (2002)
Description
「研究成果報告書概要(欧文)」より
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