2003 Fiscal Year Final Research Report Summary
Study on the functions of semaphorins and their receptors in neuron network formation
| Project/Area Number |
13309008
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
広領域
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| Research Institution | Nagoya University |
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Principal Investigator |
FUJISAWA Hajime Nagoya University, Graduate School of Science, Division of Biological Science, Professor, 大学院・理学研究科, 教授 (60079689)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Shin Nagoya University, Graduate School of Science, Division of Biological Science, Associate Professor, 大学院・理学研究科, 助教授 (90171420)
SUTO Fumikazu Nagoya University, Graduate School of Science, Division of Biological Science, Research Associate, 大学院・理学研究科, 助手 (40345848)
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| Project Period (FY) |
2001 – 2003
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| Keywords | neuron network / development / axon guidance / semaphorin / neuropilin / plexin / mouse / C.elegans |
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| Research Abstract |
Axons are navigated along particular paths towards their definite targets, after interacting with various attractive or repulsive guidance cues. Semaphorin is a family of molecules that regulate direction growth of axons. Neuropilins and plexins are semaphorin receptors.
In this study, we performed the following 5 projects in the mice and nematode C.elegans, and clarified molecular roles of semaphorins and their receptors in the establishment of neuron networks. In addition, we have found that semaphorins and their receptors played important roles in neuronal cell migration, cardiovascular development and morphogenesis of epithelial tissues, as well as neuron network formation.
1) Identification of novel plexins in the mice.
2) Production of plexin-A mutant mice by targeted gene disruption, and study on their function in vivo.
3) Identification and characterization of novel class 6 semaphorins.
4) Study of the function of semaphorin signals, by production of the neuropilin-1/neuropilin-2 double knockout mice
5) Study on plexin function in nematode C.eleganse.
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