2002 Fiscal Year Final Research Report Summary
Chemically modified STM tips for molecular imaging of DNA and cytochrome c
| Project/Area Number |
13440219
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
分離・精製・検出法
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| Research Institution | The University of Tokyo |
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Principal Investigator |
UMEZAWA Yoshio The Universily of tokyo, Graduate Schoolof Science, Professor, 大学院・理学系研究科, 教授 (80011724)
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| Project Period (FY) |
2001 – 2002
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| Keywords | STM / DNA / carbon nanotube / SAM / surface analysis / chemically modified tips / Hydrogen bonding interaction / nucteotides |
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| Research Abstract |
Cheniistry-iacilitated intermolecular electron tunneling is another approach to molecular imaging that is reported herein. The chemical imaging was obtained from a distinctive chemical affinity between the imaging tip of scanning tunneling microscopy (STM) and the substrate that afters the tunneling current. This was achieved by tailored chemical modification of the STM tips. When chemically modified tips are used for STM measurements, contrast enhancements at specific regions in STM images occur on the basis of hydrogen bond, charge-transfer, and metal-coordination interactions, and as a result, allowed to detect not only the distribution of specific chemical species and functional groups but also the orientation of functional groups. The contrast enhancements reflect the increase in a tunneling current due to the overlap of electronic wave functions induced by the chemical interactions between tip and sample. The molecular imaging of oligonucleotides was achieved therefrom.
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