2004 Fiscal Year Final Research Report Summary
Precise micro-flow analyzes for the insight into the swimming mechanism of microorganisms
| Project/Area Number |
13450096
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Intelligent mechanics/Mechanical systems
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAMIMURA Shinji The University of Tokyo, Graduate School of Arts and Sciences, Associate Professor, 大学院・総合文化研究科, 助教授 (90177585)
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| Co-Investigator(Kenkyū-buntansha) |
TAKANO Yasunari University of Shiga prefecture, Department of Mechanical Systems Engineering, Professor, 工学部, 教授 (00089111)
KOBAYASHI Shunichi Shinshu University, Graduate School of Science and Technology, Associate Professor, 繊維学部, 助教授 (50225512)
SUDA Hitoshi Tokai University, Department of Biological Science and Technology, Associate Professor, 開発工学部, 助教授 (70216472)
SHINOHARA Ken-ichi School of Materials Science, Japan Advanced Institute of Science and Technology, Associate Professor, 材料科学研究科, 助教授 (10292244)
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| Project Period (FY) |
2001 – 2004
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| Keywords | micromachine / micro-flow analyzes / flagellar motility / ciliary movement / molecular motors / functional polymer / bio-fluid mechanics / biomimetics |
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| Research Abstract |
The project started in order to invent a new micro-machine mechanism through the studies of mimetics or understanding microorganism swimming motion under low Reynolds number conditions. Kamimura, the leader of the project, improved a new real-time analyzer of flagellar beat frequency using a novel photo-sensing device. He used the equipment to study the real-time change of flagellar beat frequency of sea-urchin or trout spermatozoa, as-well as the mean velocity of random particle Brownian motion under an optical microscope. He also invented a new method to observe sperm motion in a very thin (<100nm) water film. Takano executed the mathematical simulations of micro-flows. He compared the real bending rigidity of Vibrio flagella with that obtained by his own estimation with Kirchhoff Rod Theory as well as by the calculation of bending and twisting moment of the structures. He also showed the morphology variation of flagellar shaft of Salmonella flagella that are composed of protofilamen
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ts of two (R/L) types. Calculation of real bacterial motion is now tried by using slender-body theory for flagella and boundary element methods for bacterial cell bodies. Kobayashi has done computer and model simulation of eukaryotic flagellar motility. His computer simulation showed the propulsive velocity of flagella depends on intrinsic resistance for filament shearing and bending. The simulated model was practically tried in large scale models, where elastic fins (microtubules) were slid to each other by magnetic power units mimicking the sliding activity of dynein motor units. Suda executed studies on molecular mechanism of force generation by molecular motors. He first showed sliding motion could be mimicked by a liquid droplet placed on a surface when it had a surface tension gradient. He also executed the analysis how myosin (myosin coated surface) generates force along with its configuration changes. Using the same experimental system he analyzed load-dependency of surface attractant and repulsive forces. Shinohara started studies on new functional π-conjugated polymers. He showed how new STM/AFM techniques were valuable and powerful tools in the field of polymer sciences. He observed a single polymer molecule and showed its spectral fluctuation was coupled with Brownian motion in a molecular scale. Less
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[Journal Article] Synthesis of chiral helical poly{p-(oligopinanylsiloxanyl)phenylacetylene}s and enantioselective permeability of their membranes.2004
Author(s)
Aoki, T., Fukuda, T., Shinohara, K., Kaneko, T., Teraguchi, M., Yagi, M.
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Journal Title
J.Polym.Sci. Part A : Polym.Chem. 42
Pages: 4502-4517
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Synthesis of chiral helical poly{p-(oligopinanylsiloxanyl)phenylacetylene}s and enantioselective permeability of their membranes.2004
Author(s)
Aoki, T., Fukuda, T., Shinohara, K., Kaneko, T., Teraguchi, M., Yagi, M.
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Journal Title
J.Polym.Sci.Part A : Polym.Chem. 42
Pages: 4502-4517
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] An engineering perspective on swimming bacteria : high-speed flagellar motor, intelligent flagellar flhament, and skillful swimming in viscous environments. Fillament, and Skillful Swimming in Viscous Environments.2004
Author(s)
Magariyama, Y., Kudo, S., Goto, T., Takano, T.
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Journal Title
Bio-mechanisms of Swimming and Flying (Springer-Verlag Tokyo)
Pages: 1-12
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Magnetic Properties and Microwave Absorption Properties of Polymer-Protected Cobalt Nanoparticles.2002
Author(s)
Kato, K., Sugimoto, S., Shinohara, K., Tezuka, N., Kagotani, T., Inomata, K.
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Journal Title
Mater.Trans. 43
Pages: 4063-409
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Magnetic Properties and Microwave Absorption Prperties of Polymer-Protected Cobalt Nanoparticles2002
Author(s)
Kato, Y., Sugimoto, S., Shinohara, K., Tezuka, N., Kagotani., T., Inomata, K.
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Journal Title
Mater.Trans. 43
Pages: 406-409
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Difference Between Forward and Backward Swimming Speeds of the Single-Polar-Flagellated Bacterium, Vibrio Alginolyticus.2001
Author(s)
Magariyama, Y., Masuda, S., Takano, Y., Ohtani, T., Kudo, S.
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Journal Title
FEMS Microbiology Letters 205
Pages: 343-347
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Picometer-scale dynamical X-Ray imaging of single DNA molecules.2001
Author(s)
Sasaki, Y.C., Okumura, Y., Adachi, S., Suda, H., Taniguchi, Y., Yagi, N.
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Journal Title
Physical Review Letter 87
Pages: 248102-248105
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Picometer-scale dynamical K-Ray imaging of single DNA molecules.2001
Author(s)
Sasaki, Y.C., Okumura, Y., Adachi, S., Suda, H., Taniguchi, Y., Yagi, N.
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Journal Title
Physical Review Letter 87
Pages: 248102-248105
Description
「研究成果報告書概要(欧文)」より
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[Book] An engineering perspective on swimming bacteria : high-speed flagellar motor, intelligent flagellar fillament, and skillful swimming in viscous environments. PP.1-12,In "Bio-mechanisms of Swimming and Flying"2004
Author(s)
Magariyama, Y., Kudo, S., Goto, T., Takano, Y.
Total Pages
12
Publisher
Springer-Verlag Tokyo
Description
「研究成果報告書概要(和文)」より
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