2003 Fiscal Year Final Research Report Summary
Behavioral genetic study on canine temperament
| Project/Area Number |
13460131
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKEUCHI Yukari The University of Tokyo, Graduate School of Agricultural and Life Sciences, Associate Professor, 大学院・農学生命科学研究科, 助教授 (10240730)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Yuji The University of Tokyo, Graduate School of Agricultural and Life Sciences, Professor, 大学院・農学生命科学研究科, 教授 (40157871)
KIKUSUI Takehumi The University of Tokyo, Graduate School of Agricultural and Life Sciences, Assistant, 大学院・農学生命科学研究科, 助手 (90302596)
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| Project Period (FY) |
2001 – 2003
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| Keywords | Dog / Temperament / Neurotransmitter / Temperament-related gene / Genetic Polymorphism / Single Nucleotide Polymorphism / Guide Dog / Behavioral Trait |
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| Research Abstract |
This study was conducted to reveal the genetic background of canine temperament. We first collected blood samples and behavioral scores of candidate guide dogs at the "Guide Dogs for the Blind" institution in USA. The trainers regarded aggression more important than anxiety when they judged the suitability as the guide dog. We then sequenced some target genes (neurotransmitter-associated genes) to search for genetic polymorphisms of these genes. We found several missence SNPs at the coding regions of identified genes, such as monoamine oxidase subtypes A (MAOA) and B (MAOB), serotonin transporter, 5-hydroxytriptamine receptor (5-HTR) 1B, 2A, and 2C. To analyze the breed differences of these polymorphisms, we collected blood samples and carried out a questionnaire survey to owners via veterinary practitioners. There were breed differences in all the identified polymorphisms among 7 representative breeds. By the combining the questionnaire survey and the genetic analysis, we found the relationships between the polymorphism of dopamine D4 receptor gene and "over-attachment to the owner in an unfamiliar place", that of 5HTR1B gene and "aggression". These findings may suggest that polymorphisms of neurotransmitter-associated genes are related to some of the behavioral traits in dogs, which may be responsible for inter-breeds as well as intra-breed differences of behavior predisposition.
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[Journal Article] Assessment of equine temperament questionnaire by comparing factor structure between two separate surveys.2005
Author(s)
Momozawa, Y., Kusunonse, R., Kikusui, T., Mori, Y., Takeuchi, Y., Mori, Y.
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Journal Title
Applied Animal Behaviour Science. (印刷中)
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Sequencing of canine 5-hydroxytriptamine receptor (5-HTR) 1B, 2A, 2C genes and identification of polymorphisms in the 5-HTR1B gene.2004
Author(s)
Masuda, K., Hashizume, C., Ogata, N., Kikusui, T., Takeuchi, Y., Mori, Y.
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Journal Title
Journal of Veterinary Medical Science. 66
Pages: 965-972
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Assessment of equine temperament by a questionnaire survey to caretakers and evaluation of its reliability by simultaneous behavior test2003
Author(s)
Momozawa, Y., Ono, T., Sato, F., Kikusui, T., Takeuchi, Y., Mori, Y., Kusunose, R.
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Journal Title
Applied Animal Behaviour Science 84
Pages: 127-138
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Molecular cloning of canine monoamine oxidase subtypes A (MAOA) and B (MAOB) cDNAs and their expression in the brain.2003
Author(s)
Hashizume, C., Suzuki, M., Masuda, K., Momozawa, Y., Kikusui, T., Takeuchi, Y., Mori, Y.
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Journal Title
Journal of Veterinary Medical Science. 65
Pages: 893-898
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Identification of an arginine-to-cysteine substitution caused by a single nucleotide polymorphism in the canine monoamine oxidase B gene.
Author(s)
Hashizume, C., Masuda, K., Momozawa, Y., Kikusui, T., Takeuchi, Y., Mori, Y.
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Journal Title
Journal of Veterinary Medical Science. (in press)
Description
「研究成果報告書概要(欧文)」より
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