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2002 Fiscal Year Final Research Report Summary

Study on preventing systems of fetus for uteroplacental circulatory disturbances and uteroplacental dysfunctions produced by microwaves

Research Project

Project/Area Number 13470079
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKanazawa University

Principal Investigator

NAKAMURA Hiroyuki  Kanazawa University, Graduate School of Medical Science, Associate professor, 医学系研究科, 助教授 (30231476)

Co-Investigator(Kenkyū-buntansha) KAMBAYASHI Yasuhiro  Kanazawa University, Graduate School of Medical Science, Instructor, 医学系研究科, 助手 (20345630)
NOBUKUNI Yoshitaka  Kanazawa University, Graduate School of Medical Science, Assistant Professor, 医学系研究科, 講師 (80295641)
OGINO Keiki  Kanazawa University, Graduate School of Medical Science, Professor, 医学系研究科, 教授 (70204104)
Project Period (FY) 2001 – 2002
KeywordsCRH / microwaves / uteroplacental blood flow / pregnancy / indomethacin / heat / SAR / fetus
Research Abstract

We tried to clarify preventing mechanisms including neuroendocrine systems of fetus for uteroplacental circulatory disturbances and uteroplacental dysfunctions produced by microwaves. We simulated the microwave condition in pregnant rats for the specific absorption ratio (SAR) of 0.4 W/kg, which is the maximum permissible exposure level recommended by the American Conference of Industrial Hygienists (ACGIH) and the American National Institute (ANSI). The pretreatment of intravenous (iv) administration of CRH receptor antagonist, α-helical CRH (9-41) as well as a cyclooxygenase inhibitor indomethacin prevented the uteroplacental circulatory disturbances during microwaves. Although microwaves did not induce fetal hypothalamic CRH mRNA change, the administration of bosentan or indomethacin before microwave exposure did it These results suggest a preventing system of uteroplacenta-fetus against microwaves in which fetal hypothalarnic CRH is involved in mediating uteroplacental circulation during microwaves at 0.4 W/kg. By contrast, we found that the preventing systems did not work during microwaves at 2.0 W/kg, subsequently resulting a significant increase in colonic temperature and decrease in uteroplacental blood flow. These results suggest microwaves at the SAR of 0.4 W/kg, which is the maximum permissible exposure level, is within safety levels without producing uteroplacental dysfunctions. Microwaves much above the maximum permissible level may show some harmful changes during pregnancy associated with an increase in colonic temperature produced microwaves.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Nakamura H, Matsuzaki I, Hatta K, Nobukuni Y, Kambayashi Y, Ogino K: "Nonthermal effects of mobile-phone frequency microwaves on uteroplacental functions in pregnant rats"Reprod Toxicol.. (in print).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura H, Matsuzaki I, Hatta K, Nagase H, Nobukuni Y, Kambayashi Y, Ogino K: "Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynaud's phenomenon and workers with vibration-induced white finger"Int Angiol. (in print).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura H, Ogino K, Nobukuni Y, Kambayashi Y, Matsuzaki I, Okada A: "Do microwaves produce other effects than thermal actions on uteroplacental functions in pregnant rats?"Arch Complex Environ Studies. (in print).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogino K, Nakajima M, Kodama N, Kubo M, Kimura S, Nagase H, Nakamura H: "Immunohistochemical artifact for nitrotyrosine in eosinophils or eosinophil containing tissue"Free Radic Res. 36. 1163-1170 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura H, Nagase H, Ogino K, Hatta K, Matsuzaki I: "Involvement of central, but no placental corticotropin releasing hormone(CRH) in heat stress-induced immunosuppression during pregnancy"Brain Behav Immun. 15. 43-53 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura H, Ogawa Y, Nagase H, Nakajima M, Kodama N, Ogino K, Ooshita Y: "Natural killer cell activity and its related psychological factor, sense of coherence in male smokers"J Occup Health. 43. 191-198 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura H., Nagase H., Ogino K., Hatta K., and Matsuzaki I.: "Involvement of central, but not placental corticotropin releasing hormone (CRH) in heat stress-induced immunosuppression during pregnancy"Brain Behav Immun. 15. 43-53 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogino K., Kodama N., Nakajima M., Yamada A., Nakamura H., Nagase H., Sadamitsu D., Maekawa T.: "Catalase catalyzes nitrotyrosine formation from sodium azide and hydrogen peroxide"Free Radic Res. 35. 735-747 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura H., Ogawa Y., Nagase H., Nakajima M., Kodama N., Ogino K., Ooshita Y.: "Natural killer cell activity and its related psychological factor, sense of coherence in male smokers"J Occup Health. 43. 191-198 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagase H., Ogino K., Nakamura H., Nakajima M., Yamada Y., Kodama N., Kubo M.: "Elevated serum nitric oxide metabolites in hypertensives"J Phys Fit Nutri Immunol. 11. 34-39 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogino K., Nakajima M., Kodama N., Kubo M., Kimura S., Nagase H., Nakamura H.: "Immunohistochemical artifact for nitrotyrosine in eosinophils or eosinophil containing tissue"Free Radio Res. 36. 1163-1170 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kodama N., Kambayashi Y., Kubo M., Yoneyama S., Nobukuni Y., Nakamura H., Ogino K.: "Induction of eosinophil peroxidase and nitrotyrosine formation in a human leukemia cell line, EoL-1."Cell Biochem Funct. 21. 1-8 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura H., Matsuzaki I., Hatta K., Nobukuni Y., Kambayashi Y., Ogino K.: "Nonthermal effects of mobile-phone frequency microwaves on uteroplacental functions in pregnant rats"Reprod Toxicol. (in print)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura H., Matsuzaki I., Hatta K., Nagase H., Nobukuni Y., Kambayashi Y., Ogino K.: "Blood endothelin-1 and cold-induced vasodilation in patients with primary Raynaud's phenomenon and workers with vibration-induced white finger"Int Angiol. (in print)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura H., Ogino K., Nobukuni Y., Kambayashi Y., Matsuzaki I., Okada A.: "Do microwaves produce other effects than thermal actions on uteroplacental functions in pregnant rats?"Arch Complex Environ Studies. (in print)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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