2004 Fiscal Year Final Research Report Summary
The study to elucidate the mechanisms of influences of catastrophic stress and coping style on endocrine systems, memory, and emotion.
| Project/Area Number |
13470100
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | National Cancer Center Research Institute East |
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Principal Investigator |
UCHITOMI Yosuke National Cancer Center Research Institute East, Psycho-Oncology Division, Chief, 精神腫瘍学研究部, 部長 (60243565)
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| Project Period (FY) |
2001 – 2004
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| Keywords | Stress / Hippocampus / Amygdala / Magnetic Resonance Imaging / Volume / Cancer / Cancer-related intrusive thought / Depression |
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| Research Abstract |
The aim of this study was to investigate the association between psychological distress (cancer-related recollection or major depression) and regional brain volume (hippocampus or amygdale) by the measurement of psycho-social factors or brain functions. The present research was approved by Institutional Review Board and the Ethics Committee of the National Cancer Center, Japan, and performed after getting informed consents of the subjects. The subjects were female patients (<55 years old) who had been survived 3 or more years after their breast cancer surgery between February 1998 and April 1999 at National Cancer Center Hospital, East. We assessed cancer-related recollection and major depression in the subjects by semi-structured clinical diagnostic interview for DSM-4 to investigate the association between these symptoms and psychosocial factors and between these symptoms and brain morphology. Psychological factors were assessed by the Profile of Mood States, Mental Adjustment to Can
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cer scale, and the Impact of Event Scale. Social factors were obtained by interviewing and clinical chart review. Brain images were generated on a 1.5-T MRI unit (GE Signa scanner) with three-dimensional spoiled gradient-recalled acquisition of 1.5-mm contiguous sections. Volumes of hippocampus, amygdala, and whole brain, and intracranial volume were traced manually using ANALYZE-PC software. The results suggested the association between cancer-related recollection and anxious pre-occupation. And it also suggested the association between cancer-related recollection and small volume of left hippocampus and amygdala, but no association between major depression and any regional volumes. However, we could not elucidate the causality of these associations due to cross-sectional design. Besides, the influences of cancer itself were not clear because no data in healthy controls were available. Therefore, further research with longitudinal design with healthy controls is needed to investigate these associations in detail. Less
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[Journal Article] Hippocampal volume and first major depressive episode after cancer diagnosis in breast cancer survivors.2004
Author(s)
Inagaki, M., Matsuoka, Y., Sugahara, Y., Nakano, T., Akechi, T., Fujimori, M., Imoto, S., Murakami, K, Uchitomi, Y.
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Journal Title
Am J Psychiatry 161
Pages: 2263-2270
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Manual Tracing Guideline for Volumetry of Hippocampus and Amygdala with High-Resolution MRI.2003
Author(s)
Matsuoka, Y., Mori, E., Inagaki, M., Kozaki, Y., Nakano, T., Wenner, M., Uchitomi, Y.
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Journal Title
Brian and Nerve (Japanese) 55
Pages: 690-697
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Relationship between distressing cancer-related recollections and hippocampal volume in cancer survivors.2002
Author(s)
Nakano, T., Wenner, M., Inagaki, M., Kugaya, A., Akechi, T., Matsuoka, Y., Sugahara, Y., Imoto, S., Murakami, K., Uchitomi, Y.
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Journal Title
Am J Psychiatry 159
Pages: 2087-2093
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cancer-related intrusive thoughts as an indicator of poor psychological adjustment at 3 or more years after breast surgery ; a preliminary study.2002
Author(s)
Matsuoka, Y., Nakano, T., Inagaki, M., Sugawara, Y., Akechi, T., Imoto, S., Murakami, K., Yamawaki, S., Uchitomi, Y.
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Journal Title
Breast Cancer Res Treat 76
Pages: 117-124
Description
「研究成果報告書概要(欧文)」より
