| Project/Area Number |
13470139
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
WAKAMIYA Nobutaka Asahikawa Medical College, School of Medicine, Professor, 医学部, 教授 (20210867)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUZAWA Jun Asahikawa Medical College, School of Medicine, Research Associate, 医学部, 助手 (40333695)
OGASAWARA Masahiro Asahikawa Medical College, School of Medicine, Research Associate, 医学部, 助手 (40185492)
YOSHIDA Itsuro Asahikawa Medical College, School of Medicine, Associate Professor, 医学部, 助教授 (20041816)
SUZUKI Yasuhiko Tottori University, School of Medicine, Associate Professor, 医学部, 助教授 (90206540)
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| Project Period (FY) |
2001 – 2003
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| Keywords | collectin / Scavenger receptor / lectin / microbe / 補体 / 微生物 |
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| Research Abstract |
Collectins are a family of C type lectins which have collagen-like sequences and carbohydrate recognition domains (CRD). The scavenger receptors type A and MARCO are classical type scavenger receptors which have internal collagen-like domains. Here, we found a new scavenger receptor which is a membrane type collectin from placenta (collectin placenta 1=CL-P1) that has a typical collectin collagen-like domain and a CRD. To elucidate the functions in CL-P1 in animal body is our purpose. In 3 years, we finished seven projects below,
1.Cloning of CL-P1 cDNA in human, mouse, rat, zebra fish, xenopus.
2.Establishment of CL-P1 permanent expression cells.
3.Production of soluble recombinant CL-P1 and mutant one having deletion or point mutation.
4.Discovery of binding protein against CL-P1.
5.Analyses oxidized LDLs after having different oxidation treatment.
6.Study on the promoter activity in CL-P1 5'-franking region.
7.Study on the kinetics of CL-P1 after several physiological treatments.
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