2002 Fiscal Year Final Research Report Summary
Reconstitution of intercellular gap junction in transplanted and injured heart
| Project/Area Number |
13470148
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Osaka Shoin Women's University |
|---|
Principal Investigator |
KAZUYA Tsunehiko Osaka Shoin Women's University, Faculty of liberal, professor, 学芸学部, 教授 (80150340)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOYOFUKU Toshihiko Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (60322179)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Keywords | Connexin43 / cardiac myocytes / N-cadherin / GATA-4 / semaphorin |
|---|
| Research Abstract |
The biological effects of gap and adhesion on cardiac morphogenesis have been investigated.
1.Effects of gap and adhesion molecules on the cell proliferation
Connexin43 and N-cadherin suppress the cell proliferation by induction of P21, cell cycle regulator, mediated G2/M arrest.
2.Effects of adhesion molecules on the cardiac morphogenesis
Genetically targeted N-cadherin induces the cardia bifida, the failure of single heart formation. The N-cadherin expression is regulated by GATA-4, cardiogenic factor, establishing the biological role of signaling pathway from GATA-54 to N-cadherin.
3.Identification of novel type of semaphorin to regulate cardiac morphogenesis :
Semaphorin are originally identified as a regulator for neural development. We identified new member of semaphorin family which regulates cardiac morphogenesis.
|
Research Products
(6 results)
