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2003 Fiscal Year Final Research Report Summary

Development of in-house microangiography using high-intensity quasi-monochromatic x-ray Irradiation from the linear plasma target

Research Project

Project/Area Number 13470154
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

MORI Hidezo  National Cardiovascular Center Research Institute, Department of Cardiac Physiology, Director, 心臓生理部, 部長 (90146598)

Co-Investigator(Kenkyū-buntansha) SHIRAI Mikiyasu  National Cardiovascular Center Research Institute, Department of Cardiac Physiology, Laboratory Chief, 心臓生理部, 室長 (70162758)
IIDA Hidehiro  National Cardiovascular Center Research Institute, Department of Investigative Radiology, 放射線医学部, 部長 (30322720)
TANAKA Etsuro  Tokyo University of Agriculture, Faculty of Applied Bio-science, Professor, 応用生物科学部, 教授 (80211366)
SATO Eiichi  Iwate Medical University, School of Liberal Arts and Science(Department of Physics), Associate Professor, 教養部, 助教授 (90154038)
Project Period (FY) 2001 – 2003
KeywordsQuasi-monocromatic X-ray / Plasma x-ray / Microangiography / Regeneration gtherapy / Myocardial ischemia / Myocardial infarction / Microvessels / Diabetic vasculopathy
Research Abstract

The plasma X-ray generator employs a high-voltage power supply, a low impedance coaxial transmission line, a high-voltage power supply, a low impedance coaxial transmission line, a high-voltage condenser with a capacity of 400nF, a turbo-molecular pump, thyrister pulse generator as a trigger device, and a flash x-ray tube. The high-voltage main condenser is charged up to 80 kV by the power supply, and the electric charges in the condenser are discharged to the tube after triggering the cathode electrode. The flush x-ray are then produced. As the electron flows from the cathode electrode are roughly converged to the cerium target by the electric field in the peak tube voltage was almost equal to the initial charging voltage was increased, the linear plasma x-ray source formed and the characteristic x-ray intensities of K-series line increased. The quasi-monochromatic radiography was performed by a new film-less computed radiography system.

  • Research Products

    (82 results)

All Other

All Publications (82 results)

  • [Publications] Y.Nakajima, et al.: "Possible application of plasma x-ray source to clinical radiography"SPIE. 4183. 365-372 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Sanada, et al.: "Role of phasic dynamism p38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine hearts"Circ Res. 88. 175-180 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Nagaya, et al.: "Chronic administration of ghrelin improves left ventricullar dysfunction and attenuates development of cardiac cachexia in rats with heart"Circulation. 104. 1430-1435 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Yamazaki, et al.: "Effects of nociceptin on cardiac norepinephrine and acetylcholine release evoked by ouabain"Brain Research. 904. 153-156 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Sanada, et al.: "Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors : The role of protein kinase A and p38 mitogen-activated protein kinase"Circulation. 104. 705-710 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Shirai, et al.: "Two-week, but not 1-week, hypoxic exposure enhances nitric oxide-mediated basal tone regulation in rat resistance pulmonary arteries"Eur J Phamacol. 51. 395-398 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Shirai, et al.: "KATP channels predominantly regulate conduit vessel tone in normoxic cat pulmonary arteries in vivo"Jpn J Physiol. 422. 181-184 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Kitagawa, et al.: "Effects of ketamine on in vivo cardiac sympathetic nerve endings"J Cardiovasc Pharmacol. 38. S39-S42 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Yamashita, et al.: "Role of endogenous nitric oxide generation in the regulation of vascular tone and reactivity in small vessels as investigated in transgenic miceusing synchrotron radiation microangiography"Nitric Oxide. 5. 494-503 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Nagaya, et al.: "Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure"J Clin Endocr Metab. 86. 5854-5859 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Kitakaze, et al.: "Role of cellular acidosis in production of nitric oxide in canine ischemic myocardium"J Mol Cell Cardiol. 33. 1727-1737 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "High-intensity quasi-monochromatic x-ray irradiation from the linear plasma target"SPIE. 4505. 154-164 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "Polycapillary radiography using a quasi-x-ray-laser generator"SPIE. 4508. 176-187 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] J.T.Pearson, et al.: "Future investigations of micro-macro level cardiac functions using x-ray diffraction"BME. 16. 29-35 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Kawada, et al.: "Effects of brief ischemia on myocardial acetylcholine and noradrenaline levels in anaesthetized cats"Autonomic Neuroscience : Basic and Clinical. 95. 37-42 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Kawada, et al.: "Disruption of vagal efferent axon and nerve terminal function in the postischemic myocardium"Am J Physiol Heart Circ Physiol. 283. 2687-2690 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Akiyama, et al.: "Acetylcholinesterase inhibitor elicits muscarinic receptor-mediated cholinergic transmission in the rat adrenal medulla"Advances in Behavioral Biology. 53. 65-68 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "Quasi-monochromatic radiography using a high-inensity quasi-x-ray laser generator"SPIE. 4682. 538-548 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "Fundamental study on parallel beam radiography using a polycapillary plate"SPIE. 4682. 298-310 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Kuwabara, et al.: "Inhomogeneous vasodilatory responses of rat tail arteries to heat stress : Evaluation by synchrotron radiation microangiography"Jpn J Physiol. 52. 403-408 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Kitagawa, et al.: "Effects of moderate hypothermia on norepinephrine release evoked by ouabain, tyramine and cyanide"J Cardiovasc Pharmacol. 41. 111-114 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "Quasi-monochromatic parallel radiography achieved with a plane-focus x-ray tube"Annual Report of Iwate Medical University. 37. 23-32 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "New x-ray irradiation from weakly ionized linear plasma"Annual Report of Iwate Medical University. 37. 13-22 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Ogita, et al.: "Amelioration of ischemia-and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart"JACC. 40. 998-1005 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Kitagawa, et al.: "Modulatory effects of ketamine on catecholamine efflux from in vivo cardiac sympathetic nerve endings in cats"Neuroscience Letters. 324. 232-236 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "Quasi-monochromatic parallel radiography achieved with a plane-focus x-ray tube"SPIE. 4786. 151-161 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "Irradiation of intense characteristic x-rays from weakly ionized linear plasma"Proc.of 3^<rd> Korea-Japan Joint Meeting on Medical Physics. 396-399 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "Quasi-monochromatic parallel radiography achieved with a polycapillary plate"Proc.of 3^<rd> Korea-Japan Joint Meeting on Medical Physics. 418-421 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Obara, et al.: "Applications of stroboscopic x-ray generators to high-speed radiographies including biomedical applications"SPIE. 4948. 269-274 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Komatsu, et al.: "Low-photon-energy plasma flash x-ray generator (LPFXG-2002)"SPIE. 4948. 574-579 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "Plasma flash X-ray generator (PFXG-02)"SPIE. 4948. 604-609 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Komatsu, et al.: "Compact flash x-ray generator (MFXG-02) and its applications"SPIE. 4948. 60-645 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "Quashi-monochromatic parallel flash radiography achieved with a plane-focus x-ray tube"SPIE. 4948. 646-651 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Kitagawa, et al.: "Effects of ketamine on exocytotic and non-exocytotic noradrenaline release"Neurochemistry International. 42. 261-267 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Kasahara, et al.: "Biodegradable gelatin hydrogel potentiates the angiogenic effect of FGF4 plasmid in rabbit hindlimb ischemia"JACC. 41. 1056-1062 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Nagaya, et al.: "Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells"Circulation. 108. 889-895 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Akiyama.et al.: "Inhibition of cholinesterase elicits muscarinic receptor-mediated synaptic transmission in the rat adrenal medulla"Auton Neurosci. 107. 65-73 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "Intense characteristic x-ray irradiation from weakly ionized linear plasma and applications"Jpn J Med Imag Inform Sci. 20. 154-161 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Sato, et al.: "Irradiation of intense characteristic x-rays from weakly ionized linear molybdenum plasma"Jpn J Med Phys. 23. 123-131 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Tokunaga, et al.: "In vivo monitoring of norepinephrine and its metabolites in skeletal muscle"Neurochemistry International. 43. 573-580 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Nakajima, et al.: "Possble application of plasma x-ray sorce to clinical radiography"SPIE. 4183. 365-372 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Sanada et al.: "Role of phasic dynamism p38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine hearts"Circ Res. 88. 175-180 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Nagaya, et al.: "Chronic administration of ghrelin improves left ventricullar dysfunction and attenuates development of cardiac cachexia in rats with heart"Circulation. 104. 1430-1435 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamazaki, et al.: "Effects of nociceptin on cardiac norepinephrine and acetylcholine release evoked by ouabain"Brain Research. 904. 153-156 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Sanada, et al.: "Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors ; The role of protein kinase A and p38 mitogen-activated protein kinase"Circulation. 104. 705-710 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Shirai, et al.: "Two-week, but not 1-week, hypoxic exposure enhances nitric oxide-mediated basal tone regulation in rat resistance pulmonary arteries."Jpn J Physiol. 51. 395-398 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Shirai, et al.: "KATP channels predominantly regulate conduit vessel tone in normoxic cat pulmonary arteries in vivo"Eur J Pharmacol. 422. 181-184 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Kitagawa, et al.: "Effects of ketamine on in vivo cardiac symphathetic nerve endings"J Cardiovasc Pharmacol. 38. S39-S42 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yamashita, et al.: "Role of endogenous nitric oxide generation in the regulation of vascular tone and reactivity in small vessels as investigated in transgenic mice using synchrotron radiation"Nitric Oxide. 5. 494-503 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Nagaya, et al.: "Hemodynamic, renal, and hormonal effects of ghrelin infusion in pathients with chronic heart failure"J Clin Endocr Metab. 86. 5854-5859 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Kitakaze, et al.: "Role of cellular acidosis in production of nitric oxide in canine ischemic myocardium"J Mol Cell Cardiol. 33. 1727-1737 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "High-intensity quasi-monochromatic x-ray irradiation from the linear plasma target"SPIE. 4505. 154-164 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "Polycapillary radiography using a quasi-x-ray-laser generator"SPIE. 4058. 176-187 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J.T.Pearson, et al.: "Future investigations of micro-macro level cardiac functions using x-ray diffraction"BME. 16. 29-35 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Kawada, et al.: "Effects of brief ischemia on myocardial acetylcholine and noradrenaline levels in anaesthetized cats"Autonomic Neuroscience : Basic and Clinical. 95. 37-42 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Kawada, et al.: "Disruption of vagal efferent axon and nerve terminal function in the postischemic"Am J Physiol Heart Circ Physiol. 283. H2687-H2691 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T, Akiyama, et al.: "Acetylcholinesterase inhibitor elicits muscarinic receptor-mediated cholinergic transmission in the rat adrenal medulla"Advances in Behavioral Biology. 53. 65-68 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "Quasi-monochromatic radiography using a high-inensity quasi-x-ray laser generator"SPIE. 4682. 538-548 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "Fundamental study on parallel beam radiography using a polycapillary plate"SPIE. 4682. 298-310 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Kuwabara, et al.: "Inhomogeneous vasodilatory responses of rat tail arteries to heat stress ; Evaluation by synchrotron radiation microangiography"Jpn J Physiol. 52. 403-408 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Kitagawa, et al.: "Effects of moderate hypothermia on norepinephrine release evoked by ouabain, tyramine and cyanide"J Cardiovasc Pharmacol. 41. 111-114 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "Quasi-monochromatic parallel radiography achieved with a plane-focus x-ray tube"Annual Report of Iwate Medical University. 37. 23-32 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "New x-ray irradiation from weakly ionized linear plasma"Annual Report of Iwata Medical University. 37. 13-22 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Ogita, et al.: "Amelioration of ischemia-and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart"JACC. 40. 998-1005 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Kitagawa, et al.: "Modulatory effects of ketamine on catecholamine efflux from invivo cardiac sympathetic nerve endings in cats"Neuroscience Letters. 324. 232-236 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "Quasi-monochromatic parallel radiography achieved with a plane-focus x-ray tube"SPIE. 4786. 151-161 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "Irradiation of intense characteristic x-ray from weakly ionized linear plasma"Proc.of 3^<rd> Korea-Japan Joint Meeting on Medical Physics. 396-399 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "Quasi-monochromatic parallel radiography achieved with a polycapillary plate"Medical Physics. 418-421 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Obara, et al.: "Applications of stroboscopic x-ray generators to high-speed radiographies including biomedical applications"SPIE. 4948. 269-274 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Komatsu, et al.: "Low-photon-energy plasma flash x-ray generator (LPFXG-2002)"SPIE. 4948. 574-579 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "Plasma flash x-ray generator (PFXG-02)"SPIE. 4948. 604-609 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Komatsu, et al.: "Compact flash x-ray generator (MFXG-02) and its spplications"SPIE. 4948. 640-645 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "Quasi-monochromatic parallel flash radiography achieved with a plane-focus x-ray tube"SPIE. 4948. 646-651 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Kitagawa, et al.: "Effects of ketamine on exocytotic and non-exocytotic noradrenaline release"Neurochemistry International. 42. 261-267 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Kitagawa, et al.: "Biodegradable gelatin gydrogel potentiates the angiogenic effect of FGF4 plasmid in rabbit hindlimb ischemia"JACC. 41. 1056-1062 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Nagaya, et al.: "Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial based on phagocytosing action of endothelial progenitor cells"Circulation. 108. 889-895 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Akiyama, et al.: "Inhibition of cholinesterase elicits muscarinic receptor-mediated synaptic transmission in the rat adrenal medulla"Auton Neurosci. 107. 65-73 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "Irradiation of intense characteristic x-rays from weakly ionized linear molybdenum plasma"Jpn J Med Phys. 23. 123-131 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Tokunaga, et al.: "In vivo monitoring of norepinephrine and its metabolites in skeletal muscle"Neurochemistry International. 43. 573-580 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Sato, et al.: "Intense characteristic x-ray irradiation from weakly ionized linear plasma and applications"Jpn J Med Imag Inform Sci. 20. 154-161 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Shirai, et al.: "Changes in functional and histological distributions of nitric oxide synthase caused by chronic hypoxia in rat small pulmonary arteries"Brit J Pharmacol. 139. 899-910 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Nagaya, et al.: "Repeated inhalation of adrenomedullin ameliorates pulmonary hypertension and survival in monocrotaline rats"Am J Physiol Heart Circ Physiol. 54. 2125-2131 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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