2003 Fiscal Year Final Research Report Summary
Structure biology for the causative genes of atopy and order-made therapy in the environment.
| Project/Area Number |
13470163
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Gifu University |
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Principal Investigator |
KONDO Naomi Gifu University, School of Medicine, Professor, M.D., 医学部, 教授 (50124714)
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| Project Period (FY) |
2001 – 2003
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| Keywords | atopy / Interferon-γ / IL-12 receptor / IgE / causative genes / IL-18 receptor |
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| Research Abstract |
The causative genes of allergy have been newly found and the causative molecules (protein) have been structurally analyzed.
Moreover, order-made therapy have been developed.
(1)IgE production suppression systems and their defects.
The mutations of IL-12 receptor β2 chain gene have been identified as one of the causative genes for allergy. Some patients with high levels of IgE production had the mutations of IL-12 receptor β2 chain gene. IL-12 was not able to inhibit IgE production of the patients' peripheral blood mononuclear cells. Therefore, it was indicated that these mutations induced high levels of IgE production and allergic reactions.
Next, the mutations of IL-18 receptor α2 chain gene have been identified as the causative gene for allergy. Some patients with high levels of IgE production had the mutations of IL-18 receptor α2 chain gene. IL-18 was not able to inhibit IgE production of the patients' peripheral blood mononuclear cells. Therefore, it was indicated that these mutations also induced high levels of IgE production and allergic reactions.
(2)Structural analysis of the causative genes.
Moreover, we have published the information of structure of HAS protein by NMR.
(3)Development of order-made therapy.
Furthermore, we have published the genetical classification of atopy for clinical or prevention of allergy and order-made therapy have been published.
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