2003 Fiscal Year Final Research Report Summary
Development of a cardiopulmonary support system with excellent antithrombogenicity and durability that enables continuous long-term perfusion with minimum anticoagulant therapy
| Project/Area Number |
13470247
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
TAKANO Hisateru National Cardiovascular Center Research Institute, Deputy, 副所長 (60028595)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKIYA Tomonori National Cardiovascular Center Research Institute, Department of Artificial Organs, Staff researcher, 人工臓器部, 室員 (00311449)
TATSUMI Eisuke National Cardiovascular Center Research Institute, Department of Artificial Organs, Laboratory chief, 人工臓器部, 室長 (00216996)
TAENAKA Yoshiyuki National Cardiovascular Center Research Institute, Department of Artificial Organs, Director, 人工臓器部, 部長 (00142183)
本間 章彦 国立循環器病センター研究所, 人工臓器部, 室員 (20287428)
TAKEWA Yoshiaki National Cardiovascular Center Research Institute, Department of Artificial Organs, Laboratory chief, 人工臓器部, 室長 (20332405)
NISHINAKA Tomohiro National Cardiovascular Center Research Institute, Department of Artificial Organs, Laboratory Chief (00256570)
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| Project Period (FY) |
2001 – 2003
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| Keywords | Artificial lung / centrifugal pump / Cardiopulmonary support / anticoagulant therapy / Heparin bonding techenique |
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| Research Abstract |
We have develop a new ECMO system which has an excellent antithrombogenicity and durability, aiming at facilitating prolonged ECMO support using newly developed heparin bonding technique (T-NCVC), a newly-developed membrane oxygenator (Platinum Cube NCVC), and a long-term durable centrifugal blood pump. Our results indicated that our newly developed ECMO system possesses a potential to perform prolonged circulatory support with minimum anticoagulants. In the evaluation using animals, all the ECMO systems could be maintained in the stable condition at least up to 65 days without systemic anticoagulants. All the animals except for one were able to be preserved until scheduled termination of experiments. No serum leakage from the oxygenators was observed, and the gas exchange performance was constantly retained. The pump performance was also sustained to deep purposed blood flow, and no significant hemolysis was observed. The changes of blood components and coagulation relating factors were ranged within quite small extent, which indicates that this ECMO system provides high blood compatibility. This ECMO system is an innovative system which has a potential to realize long-term perfusion without anticoagulants and device exchanges. It will realize the improvement of clinical results in the treatment of severe respiratory and/or circulatory distress patients, and furthermore, this system should change the concept of ECMO due to its long-term durability and high antithrombogenicity, especially in the application for such patients with difficulty in the anticoagulant therapy.
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[Publications] 西中知博, 巽 英介, 妙中義之, 片桐伸将, 大西裕幸, 押川満雄, 塩谷恭子, 福田敏秀, 築谷朋典, 本間章彦, 武輪能明, 高野久輝, 佐藤正喜, 柏原 進, 田中秀典, 酒井一成, 松田智昌: "優れた抗血栓性と長期耐久性を有する心肺補助システムの開発"模型肺. 25. 53-57 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Nishinaka T., Tatsumi E., Taenaka Y., Katagiri N., Ohnishi H., Shioya K., Fukuda T., Oshikawa M., Sato K., Tsukiya T., Homma A., Takewa Y., Takano H., Sato M., Kashiwabara S., Tanaka H., Sakai K., Matsuda T.: "At least thirty-four days of animal continuous perfusion by a newly developed extracorporeal membrane oxygenation system without systemic anticoagulants."Artificial Organs. 26. 548-551 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Nishinaka T., Tatsumi E., Taenaka Y., Katagiri N., Ohnishi H., Oshikawa M, Shioya K., Tsukiya T, Fukuda T, Homma A, Takewa Y, Takano H., Sato M., Kashiwabara S., Tanaka H., Sakai K., Matsuda T.: "Development of a cardiopulmonary support system with excellent antithrombogenicity and durability."Membrane Oxygenator. 25. 53-57 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Nishinaka T., Tatsumi E., Taenaka Y., Katagiri N., Ohnishi H., Shioya K., Fukuda T., Oshikawa M., Sato K., Tsukiya T., Homma A., Takewa Y., Takano H., Sato M., Kashiwabara S., Tanaka H., Sakai K., Matsuda T.: "At least thirty-four days of animal continuous perfusion by a newly developed extracorporeal membrane oxygenation system without systemic anticoagulants."Artificial Organs. 26-6. 548-554 (2002)
Description
「研究成果報告書概要(欧文)」より
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