| Research Abstract |
With the application of anti-cancer chemotherapy, the prognosis of various malignant tumors including cancers, leukemia and sarcomas was greatly improved. However, those, that have presently become the barrier in order to treat the tumors, are the problems of multidrug resistance to anti-cancer agents. In order to the various biological events that are related to the drug resistance, and to apply the obtained findings to the tumor treatments, this research project had been started.
In the process of this project, we identified 5 candidate genes relating to the drug resistance, and one novel molecule among the those, RB1CC1 (RB1-inducible Coiled-Coil1), were closely associated with RB1 (retinoblastoma 1) tumor suppressor, and we also related RB1CC1 to the developments of various cancers. Therefore, the functional analysis of this novel molecule RB1CC1, and the mutation analysis of RB1CC1I gene in the cancers were mainly performed at the latter half of the project period. Then, we performed the achievements such as mentioned on the next page.
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