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2002 Fiscal Year Final Research Report Summary

Optical recording studies on segmentation and induction of sounds in the auditory cortex

Research Project

Project/Area Number 13480096
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Intelligent informatics
Research InstitutionToyohashi University of Technology

Principal Investigator

HORIKAWA Junsei  Toyohashi Univ.of Tech., Dept.Knowledge-based Information Eng., Prof., 工学部, 教授 (50114781)

Co-Investigator(Kenkyū-buntansha) HOSOKAWA Yutaka  Tokyo Med & Dent.Univ., Med.Res.Inst., Assist.Prof., 難治疾患研究所, 助手 (80181501)
Project Period (FY) 2001 – 2002
Keywordsprimary auditory cortex / optical recording / voltage-sensitive dye / segmentation of sound / gap / suditory induction / spatiotemporal neural activity / guinea pig
Research Abstract

This study was aimed to investigate neural mechanisms of grouping, segregation and temporal induction of sounds. Using an optical imaging technique with a voltage-sensitive dye RH795, neural activity was recorded in the primary auditory cortex (AI) of anesthetized guinea pigs. Complex tones (CT, 200-ms long) consisting of two pure-tones (PT) with 0-2.0-octave frequency separations and 0-100-ms time delays were used to study grouping and segregation. Gap-inserted (PGP) and white-noise (WN)-inserted pure tones (PWP) with 0-120-ms gap and WN lengths were used to study induction. They were presented to the ear contralateral to the recording cortex.
In response to CT, strength of AI activity and widths of responding areas increased at 0.2-0.7 octave but did not at more than 0.8 octave. If one component in the CT was delayed more than 5ms from the other, the response to the delayed component was inhibited by the preceding one. These results suggest that AI of guinea pigs has a mechanism to group sounds with near frequencies (less than 0.7 octave) and short delays (less than 10 ms) and to separate those with far frequencies and long delays.
When PGP with a gap shorter than 5 ms was presented, the AI response appeared only at the onset of the pre-gap tone, while it appeared at both the onsets of pre- and post-gap tones if the gap was longer than 5 ms. If WN was inserted into the gap, the response appeared only at the onset of the pre-WN tone, even if the WN period was longer than 5ms. These results suggest that the insertion of WN increases the threshold of gap detection in AI and this phenomenon may relate to auditory induction mechanism in the brain.

  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] J.Horikawa, A.Hess, M.Nasu, Y.Hosokawa, H.Scheich, I.Taniguchi: "Optical imaging of neural activity in multiple auditory cortical fields of guinea pigs"Neuro Report. 12. 3335-3339 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] J.Horikawa, A.Hess, Y.Hosokawa, I.Taniguchi: "Spatiotemporal processing of auditory information in multiple auditory areas of the guinea pig auditory cortex : an optical recording study"Advances in Ethology, XXVII International Ethologial Conference, Tuebingen, Germany,. 36. 23 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Hosokawa, J.Horikawa, M.Nasu, I.Taniguchi: "Optical imaging of azimuthal activities in multi-fields of the guinea pig auditory cortex"Advances in Ethology, XXVII International Ethologial Conference, Tuebingen, Germany,. 36. 180 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] J.Horikawa, Y.Hosokawa, I.Taniguchi: "Optical recording from guinea pig auditory cortex in vivo"Jpn. J. Physiol.. 51. S47 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 片桐ちはる, 堀川順生: "無音区間の検知閾:純音、周波数変調音、雑音での比較"日本音響学会聴覚研究会資料. 31:9 H-2001-86. 637-643 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] J.Horikawa, T.Kurai, D.Uneme, T.Hatta, M.Ohta, I.Taniguchi: "Optical imaging of neural activities of primary auditory cortex in response to sounds containing a noise period"Neurosci. Res.. Suppl.25. S59 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Yamaguchi, J.Horikawa, I.Taniguchi: "Neural dynamics of vocal processing in the auditory cortex"Biophysical Neural Networks, (Ed. R. R. Poznanski), (Mary Ann Liebert Inc., NY.). 343-362 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugimoto, S., Hosokawa, Y., Horikawa, J., Nasu, M., Taniguchi, I.: "Spatial focusing of neuronal responses induced by asynchronous two-tone stimuli in the guinea pig auditory cortex"Cerebral Cortex. 12. 506-514 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀川順生: "電位感受性色素による聴覚皮質活動の解析"第16回日本エム・イー学会秋季大会論文集.生体医工学. 40 Suppl.2. 169-170 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugimoto, S., Hosokawa, Y., Horikawa, J., Nasu, M., Taniguchi, I.: "Optical recordings of auditory cortical responses induced by asynchronous two-tone stimuli"Jpn. J. Physiol.. 52 Suppl.. S151 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohta, M., Hatta, T., Horikawa, J., Taniguchi, I.: "Optical imaging of of response patterns to pure tones, white noise and clicks in primary and higher auditory cortex of guinea pigs"Jpn. J. Physiol.. 52 Suppl.. S151 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hosokawa, Y., Horikawa, J., Nasu, M.Taniguchi, I.: "Electrophysiological study of neural activity to azimuthal sounds in multiple auditory cortical fields of guinea pigs"Jpn. J. Physiol.. 52 Suppl.. S152 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 細川浩, 窪田道典, 谷口郁夫, 堀川順生: "モルモット聴覚皮質における両耳応答の光学計測-中心領域と周辺領域の比較-"日本音響学会聴覚研究会資料. 32:9 H-2002-81. 521-525 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Horikawa, J., Hess, A., Hosokawa, Y., Taniguchi, I.: "Spatiotemporal processing in the guinea pig auditory cortex""Behavior and Neurodynamics for Auditory Communication" Eds. J. kanwal and G. Ehret, (Cambridge University Press). (in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] J.Horikawa, A.Hess, M.Nasu, Y.Hosokawa, H.Scheichi, and I.Taniguchi: "Optical imaging fo neural activity in multiple auditory cortical fields of guinea pigs"NeuroReport. 12. 3335-3339 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J.Horikawa: "Auditory maps in the brain (in Japanese)"J.Acoust.Soc.Jpn.. 57. 58 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J.Horikawa, A.Hess, M.Nasu, Y.Hosokawa and I.Taniguchi: "Spatiotemporal processing of auditory information in multiple auditory areas of the guinea pig auditory cortex : an optical recording study"27th International Ethological Conference, Symposium 2 "Cracking the code for auditory communication", Tuebingen, Germany, Advances in Ethology. 36. 23 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Hosokawa, J.Horikawa, M.Nasu and I.Taniguchi: "Optical imaging of azimuthal activities in multi-fields of the guinea pig auditory cortex"27th International Ethological Conference, Tuebingen, Germany, Advances in Ethology. 36. 180 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Katagiri, and J.Horikawa: "Threshold of gap detection in pure tones and frequency-modulated sounds with or without background noise. (in Japanese)"Trans.Tech.Comm.Psychol.Physiol.Acoust.. 31:9, H-2001-86. 637-643 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J.Horikawa, Y.Hosokawa, and I.Taniguchi: "Optical recording from guinea pig auditory cortex in vivo"Jpn.J.Physiol.. 51. S47 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Hosokawa, J.Horikawa, M.Nasu and I.Taniguchi: "Optical imaging of neural activities evoked by azimutal sound in multi-fields of the guinea pig auditory cortex"Jpn.J.Physiol.. 51. S208 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J.Horikawa, T.Kurai, D.Uneme, T.Hatta, M.Ohta and I.Taniguchi: "Optical imaging of neuronal activities of primay auditory cortex in response to sounds containing a noise period"Neurosci.Res.Suppl.. 25. S59 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Sugimoto, Y.Hosokawa, J.Horikawa, M.Nasu and I.Taniguchi: "Spatial focusing of neural responses induced by asynchronous two-tone stimuli in the guinea pig auditory cortex"Cerebral Cortex. 12. 506-514 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J.Horikawa: "Optical imaging of auditory cortex in vivo using a voltage-sensitive dye. (in Japanese)"Jpn.J.Med.Biol.Eng.. 40:suppl.2. 169-170 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Sugimoto, Y.Hosokawa, J.Horikawa, M.Nasu and I.Taniguchi: "Optical recordings of auditory cortical responses induced by asynchronous two-tone stimuli"Jpn.J.Physiol.. 52:Suppl.. S151 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Hosokawa, M.Kubota, I.Taniguchi and J.Horikawa: "Optical recording of responses in the guinea pig auditory cortex during binaural stimulation-the comparison between central and surround areas. (in Japanese)"Trans.Tech.Comm.Psychol.Physiol.Acoust.. 32:9, H-2002-81. 521-525 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Ohta, T.Hatta, J.Horikawa and I.Taniguchi: "Optical imaging of of response patterns to pure tones, white noise and clicks in primary and higher auditory cortex of guinea pigs"Jpn.J.Physiol.. 52:Suppl.. S151 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Hosokawa, J.Horikawa, M.Nasu and I.Taniguchi: "Electrophysiological study of neural activity ot axzimuthal sounds in multiple auditory corrtical fields of the guinea pigs"Jpn.J.Physiol.. 52 Suppl.. S152 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Yamaguchi, J.Horikawa and I.Taniguchi, Ed.R.R.Poznanski: "Neural dynamics of vocal processing in the auditory cortex, in Biophysical Neural Networks"Mary Ann Liebert, Inc., NY. 343-362 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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