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2003 Fiscal Year Final Research Report Summary

Mechanisms of formation, maintenance and extinction of olfactory learning

Research Project

Project/Area Number 13480268
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionKochi University

Principal Investigator

KABA Hideto  Kochi University, Faculty of Medicine, Professor, 医学部, 教授 (50136371)

Co-Investigator(Kenkyū-buntansha) MURAMOTO Kazuyo  Kochi University, Faculty of Medicine, Instructor, 医学部, 助手 (10301798)
OKUTANI Fumino  Kochi University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (10194490)
TAKAHASHI Seiichi  Kochi Medical School, Faculty of Medicine, Associate Professor, 医学部, 助教授 (40271093)
TANIGUCHI Mutsuo  Kochi University, Faculty of Medicine, Instructor, 医学部, 助手 (10304677)
Project Period (FY) 2001 – 2003
Keywordslearning / accessory olfactory bulb / olfactory bulb / long-term potentiation / noradrenaline / CREB / MAP kinase / GABA_B receptor
Research Abstract

Female mice learn to recognize the urinary pheromones of the male with which they mate. This olfactory learning is associated with substantial neural changes in the accessory olfactory bulb(AOB), first relay in the vomeronasal system. We show in AOB slices that glutamatergic transmission from mitral cells, a single class of projection neurons, to granule cell inhibitory interneurons, displays long-term potentiation(LTP), which shares essential features with pheromonal learning, following spaced and long-term theta frequency stimulation of mitral cell axons and that noradrenaline enhances the induction of LTP via presynaptic α_2-adrenergic receptor-mediated inhibition of glutamate release that allows the postsynaptic cell to fire more action potentials during theta frequency stimulus train due to a reduction in depolarising plateau. Our findings provide a unique cellular mechanism for the noradrenergic modulation of olfactory learning.
On postnatal day 12, young rats show an aversion to an odor to which they has been exposed along with presentation of foot shock on postnatal day 11. We show that the mitogen-activated protein kinase/extracellular-signal regulated kinase(MAPK/ERK)-cyclic AMP response element binding protein(CREB) pathway in the olfactory bulb(OB) is required for the long-term, but not the short-term, facilitation process of aversive olfactory learning in young rats. We also show that both of GABA_A and GABA_B reeptors in the OB are involved in the regulation of aversive olfactory learning.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Taniguchi, M.: "Properties of reciprocal synapses in the mouse accessory olfactory bulb"Neuroscience. 108. 365-370 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Zhang, J.-J.: "Activation of the cyclic AMP response element-binding protein signaling pathway in the olfactory bulb is required for the acquisition of olfactory aversive learning in young rats"Neuroscience. 117. 707-713 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Zhang, J.-J.: "Activation of the MAPK/ERK signaling pathway leading to CREB phosphorylation is required for the long-term facilitation process of aversive olfactory learning in young rats."Neuroscience. 121. 9-16 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okutani, F.: "Modulation of olfactory learning in young rats through intrabulbar GABA_B receptors"European Journal of Neuroscience. 18. 2031-2036 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuoka, M.: "Remodeling of reciprocal synapses associated with persistence of long-term memory"European Journal of Neuroscience. 19. 1668-1672 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 椛 秀人: "アロマサイエンス・シリーズ21「においと脳・行動」"フレグランスジャーナル. 336 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Otsuka, T.: "Modulation of dendrodendritic interactions and mitral cell excitability in the mouse accessory olfactory bulb by vaginbcervical stimulation."Eur.J.Neurosci.. 13. 1833-1838 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Otsuka, T.: "Activation of GABA_A receptors in the accessory olfactory bulb does not prevent the formation of an olfactory memory in mice."J.Vet.Med.Sci.. 63. 807-809 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okere, C.O.: "Stimulus-dependence of NO-mediated neuronal activation : a Fos expression study in the hippocampus and cortex of lactating rats."Neuro Report. 12. 2859-2864 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Taniguchi, M.: "Properties of reciprocal synapses in the mouse accessory olfactory bulb."Neuroscience. 108. 365-670 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okutani, F.: "Non-specific olfactory aversion induced by intrabulbar infusion of the GABA_A receptor antagonist bicuculline in young rats."Neuroscience. 112. 901-906 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Zhang J-J: "Activation of the cyclic AMP response element-binding protein signaling pathway in the olfactory bulb is required for the acquisition of olfactory aversive learning in young rats."Neuroscience. 117. 707-713 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Zhang J-J: "Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway leading to cyclic AMP response element-binding protein phosphorylation is required for the long-term facilitation process of aversive olfactory learning in young rats."Neuroscience. 121. 9-16 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okutani, F.: "Modulation of olfactory learning in young rats through intrabulbar GABA_B receptors."Eur.J.Neurosci.. 18. 2031-2036 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuoka, M.: "Remodeling of reciprocal synapses associated with persistence of long-term memory."Eur.J.Neurosci.. 19. 1668-1672 (2004)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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