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2003 Fiscal Year Final Research Report Summary

Experimental verification of causal relationships between measurements of near-infrared spectroscopy and mechanisms of oxygen transport to skeletal muscles

Research Project

Project/Area Number 13480286
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

YAMAMOTO Katsuyuki  Hokkaido Univ., Graduate School of Eng., Prof., 大学院・工学研究科, 教授 (10088867)

Co-Investigator(Kenkyū-buntansha) KAWAHARA Koichi  Hokkaido Univ., Research Institute of Electronic Science, Prof., 電子科学研究所, 教授 (20125397)
HAMAOKA Takafumi  National Institute of Fitness and Sports in Kanoya, Prof., 体育学部, 教授 (70266518)
KUDO Nobuki  Hokkaido Univ., Graduate School of Eng., Instructor, 大学院・工学研究科, 助手 (30271638)
Project Period (FY) 2001 – 2003
Keywordsnear-infrared light / tissue oxygenation / skeletal muscle / oxygen consumption / hemoglobin / myoglobin / microphotospectroscopy
Research Abstract

The purpose of this research project was to experimentally verify the causal relationships between measurements of near-infrared spectroscopy and the mechanisms of oxygen transport to the skeletal muscles. These relationships are essential for understanding temporal responses of NIRS measurements. The following results were obtained from measurements in volunteers, computer simulation of tissue metabolism and microspectroscopic studies in animals.
(1) Spatio-temporal analyses of muscle metabolism based on muscle oxygenation imaging : An imaging system of muscle oxygen saturation using spatially resolved spectroscopy was newly developed. Muscle oxygen saturation during exercise and recovery showed distinct features depending on a pattern of exercise and an amount of oxygen debt
(2) Instantaneous measurement of muscle oxygen consumption during exercise : Utilizing the cease of blood flow due to strong contraction, we developed a technique for measuring a local oxygen consumption rate of mu … More scles that was determined from a decreasing rate of tissue oxygen concentration. Oxygen consumption rates during contraction were instantaneously measured without arterial occlusion using a newly developed device that had a high-speed sampling rate of 0.1 s
(3) Computer simulation of muscle metabolism for analyses of NIRS measurements : A model of muscle metabolism consisting of aerobic and anaerobic systems, phosphagen energy system and oxygen transport system was constructed, and results of simulation were compared with those of the actual measurements. It was strongly suggested that contribution rates of hemoglobin (Hb) and myoglobin (Mb) to NIRS measurements depend on a muscle oxygenation level, reflecting the great difference between the dissociation curves of Hb and Mb.
(4) Measurement of tissue oxygen saturation using microspectroscopy : A 6-wavelength microspectroscopic system was constructed for studying oxygen transport to tissues. Scattering component was eliminated by a multiple regression method. Oxygen saturation of small vessels was able to be imaged in the mesenteries and cremaster muscles of mice and rats. Less

  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] K.Yamamoto: "Functional imaging muscle oxygenation using a 200-ch CW-NIRS system"Proc.SPIE. 4250. 142-152 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山本克之: "皮下脂肪層を考慮した近赤外分光法の利用と今後の展開"体育の科学. 51(7). 518-521 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] J.Shao: "Theoretical and experimental studies on linear and nonlinear algorithms for the measurement of muscle oxygenation using continuous-wave near-infrared spectroscopy"Optical Engineering. 40(10). 2293-2301 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中村和明: "超音波変調光による生体の光イメージングに関する基礎的検討-スペックルパターンの変動を利用した変調光の検出-"電子情報通信学会論文誌A. J84-A(12). 1525-1531 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 工藤信樹: "超音波照射下における微小気泡のふるまいの高速度カメラによる観察"電子情報通信学会論文誌A. J84-A(12). 1492-1499 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Niwayama: "A 200-channel imaging system of muscle oxygenation using CW near-infrared spectroscopy"IEICE Trans. E85-D(1). 115-123 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Yamamoto: "Optical topography for spatiotemporal analyses of muscle oxygenation during exercise"Lecture Notes of the ICB Seminars. 84-99 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Hirai: "Development of an imaging system of muscle oxygenation based on spatially resolved near-infrared spectroscopy"Proceedings of Asian Symposium on Biomedical Optics and Photomedicine. 192-193 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Kudo: "Basic studies on optical imaging of biological tissues using speckle patterns of ultrasound-modulated light"Proceedings of Asian Symposium on Biomedical Optics and Photomedicine. 234-235 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Kudo: "Study on mechanisms of cell damage caused by microbubbles exposed to ultrasound"2002 IEEE Ultrasonics Symposium Proc.. 1351-1354 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 工藤信樹: "気泡のふるまいの可視化"映像情報メディカル. 34(6). 572-574 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山本克之: "生体計測への近赤外分光法の応用"BME. 17(4). 54-60 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 工藤信樹: "超音波によるスペックルパターンの変調を利用した生体の光イメージング"超音波テクノ. 15(5). 65-68 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kawahara: "Increased vulnerability to ishchemia/reperfusion-induced ventricular tachyarrythmias by pre-ischemia inhibition of nitric oxide synthase in isolated rat hearts"Cardiovascular Pathology. 12. 49-56 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kawahara: "Ruthenium red-induced transition from ventricular fibrillation to tachycardia in isolated rat hearts : possible involvement of changes in mitochondrial calcium uptake"Cardiovascular Pathology. 12. 311-321 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Yamamoto, M.Niwayama, D.Kohata, N.Kudo, T.Hamaoka, R.Kime, T.Katsumura: "Functional imaging muscle oxygenation using a 200-ch CW NIRS system"Proc.SPIE. 4250. 142-152 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Yamamoto: "Applications and future progress of near-infrared spectroscopy taking into account the influence of subcutaneous adipose tissue (in Japanese)"Taiiku-no Kagaku. 51(7). 518-521 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J.Shao, L.Lin, M.Niwayama, N.Kudo, K.Yamamoto: "Theoretical and experimental studies on linear and nonlinear algorithms for the measurement of muscle oxygenation using continuous-wave near-infrared spectroscopy"Optical Engineering. 40(10). 2293-2301 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Nakamura, S.Jun, N.Kudo, M.Kitama, K.Misawa, J.Arisawa, K.Yamamoto: "Basic studies on optical imaging of biological tissues using ultrasound-modulated light -Detection of ultrasound-modulated light using variations in speckle patterns -(in Japanese)"IEICE Transactions A. J84-A(12). 1525-1531 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Kudo, K.Kuribayashi, M.Nator, F.Moriyasu, K.Yamamoto: "Observations of microbubbles exposed to ultrasound using a high-speed camera (in Japanese)"IEICE Transactions A. J84-A(12). 1492-1499 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Niwayama, K.Yamamoto, D.Kohata, K.Hirai, N.Kudo, T.Hamaoka, R.Kime, T.Katsumura: "A 200-channel imaging system of muscle oxygenation using CW near-infrared spectroscopy"IEICE Trans. E85-D(1). 115-123 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Yamamoto, K.Hirai, D.Kohata, M.Niwayama, N.Kudo: "Optical topography for spatiotemporal analyses of muscle oxygenation during exercise"Lecture Notes of the ICB Seminars, Laser-Doppler Flowmetry and Near Infrared Spectroscopy in Medical Diagnosis. 84-99 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Hirai, K.Maegawa, D.Kohata, N.Kudo, K.Yamamoto: "Development of an imaging system of muscle oxygenation based on spatially resolved near-infrared spectroscopy"Proceedings of Asian Symposium on Biomedical Optics and Photomedicine. 192-193 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Kudo, K.Nakamura, J.Shao, M.Kitama, K.Yamamoto: "Basic studies on optical imaging of biological tissues using speckle patterns of ultrasound-modulated light"Proceedings of Asian Symposium on Biomedical Optics and Photomedicine. 234-235 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Kudo, T.Miyaoka, K.Okada, K.Yamamoto: "Study on mechanisms of cell damage caused by microbubbles exposed to ultrasound"2002 IEEE Ultrasonics Symposium Proc.. 1351-1354 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Kudo, K.Yamamoto: "Imaging of behavior of microbubbles (in Japanese)"J.Medical Imaging and Information. 34(6). 572-574 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Yamamoto: "Applications of near-infrared spectroscopy to biological measurements (in Japanese)"BME. 17(4). 54-60 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Kudo, K.Yamamoto: "Biological optical imaging using ultrasound-modulated speckle patterns (in Japanese)"Ultrasonic Technology. 15(5). 65-68 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kawahara.M.Takase, Y.Yamauchi: "Increased vulnerability to ishchemia/reperfusion-induced ventricular tachyarrythmias by pre-ischemia inhibition of nitric oxide synthase in isolated rat hearts"Cardiovascular Pathology. 12. 49-56 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kawahara, M.Takase, Y.Yamauchi: "Ruthenium red-induced transition from ventricular fibrillation to tachycardia in isolated rat hearts : possible involvement of changes in mitochondrial calcium uptake"Cardiovascular Pathology. 12. 311-321 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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