• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2003 Fiscal Year Final Research Report Summary

A new exercise training program for the elderly by developing a novel handy calorie meter and an IT network system after the determination of human genome sequences.

Research Project

Project/Area Number 13557005
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionShinshu University

Principal Investigator

NOSE Hiroshi  Shinshu Uniersity Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (40128715)

Co-Investigator(Kenkyū-buntansha) HIGUCHI Kei-ichi  Shinshu Uniersity Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (20173156)
Project Period (FY) 2001 – 2003
Keywordscalorie meter / muscle strength / exercise training / IT network / genes / animal models
Research Abstract

The purpose of the present project was to develop a exercise training program which can be applied to over several thousands elderly people by developing a novel handy calorie meter and an IT network, and moreover, to establish animal models to investigate individually different responses to the program from genetic background. Summary of the project is as follows,
1)The development of a calorie meter :
We successfully developed a novel handy calorie meter to measure energy expenditure precisely during exercise above the intensity of walking. Moreover, we are able to estimate muscle strength of the thigh by measuring acceleration in the 3 dimensions : fore back, right-left, and up-down, during walking at the maxial speed.
2)The development of exercise training program suitable for individuals by IT network :
We confirmed in 200 elderly voluanteers that estimated maximal aerobic power (VO_<2,max>) increased by 10-20% after the training regimen ; walking at the high speed of 60-70% VO_<2,max … More >, 3Omin/ day, 3 day/week, for 6 months. The individual enegy expenditure during the training period was recorded by the calorie meter. The data were transferred to a host computer through terminal computers at a given interval, and inversely, the effects by the training on blood chemicals, blood pressure, and physical fitness were sent to the teriminal computer for the individuals in a feed back manner. By this system, several thousands of elderly people will be able to participate the program even though there are riot satisfactory number of facilities for physical training or trainers.
3)The development of animal models to discover the genes well responding to physical training :
We developed animal models to discover the gene well responding to physical training. For example, we investigated the role of calponin in arterial pressure regulation. Calponin is known to be a mediator in the vascular smooth muscle associating with α-adrenergic vasoconstriction. We found that arterial pressure regulation was impaired in the calponin knockout mice, genetically deficient of calponin, and that. they were not able to run at the high intensity as control mice. Moreover, we found that arterial pressure regulation was impaired in CRY, a key gene to generate circadian rhythm of activity, double knockout mice since α-adrenergic receptors were not expressed. in the vascular smooth muscles. These are promising findings to fill the gap between molecular bilogy and system physiology. We will be able to extend these to human studies by introducing the system stated above. Less

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] S.Iwashita et al.: "Triaxial accelerometry to evaluate walking efficiency in older subjects."Medicine & Science in Sports & Exercise. 35. 1766-1772 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Masuki et al.: "Enhanced baroreflex sensitivity in free-moving calponin knockout mice."Am.J.Physiol. Heart Cinc Physiol. 284. H939-H946 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Masuki et al.: "Arterial baroreflex control of muscle blood flow at the onset of voluntary locomotion in mice"J.Physiol.. 553. 191-201 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Masuki et al.: "Impaired arterial pressure regulation during exercise due to enhanced muscular vasodilatation in calponin KO mice"J.Physiol.. 553. 203-212 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Okazaki et al.: "Effects of exercise training on thermoregulatory and blood volume in older men."J.Appl.Physiol.. 93. 1630-1637 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Takeno et al.: "Thermoregulatory & aerobic changes after endurance training in a hypobalic hypoxic and warm environment."J.Appl.Physiol.. 91. 1520-1528 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nose H, et al.: "Exercise, Nutrition, and Environmental Stress Vol.3"Cooper Publishing Group. 283 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Iwashita et al.: "Triaxial accelerometer to evaluate working efficiency in older subjects"Medicine & Science in Sports & Exercise. 35. 1766-1772 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S, Masuki et al.: "Enhanced barorefex sensitivity in free-moving calponin knockout mice"Am.J.Physiol.Heart Circ.Physiol.. 284. H939-H946 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Masuki et al.: "Arterial baroreflex control of muscle blood flow at the onset of voluantary locomotion in mice"J.Physiol. (Lond.). 553. 191-201 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Masuki et al.: "Impaired arterial pressure regulation during exercise due to enhanced muscular vasodilation in calponin knockout mice"J.Physiol. (Lond). 553. 203-212 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Okazaki et al.: "Effects of exercise training on thermoregulatory and blood volume in older men."J.Appl.Physiol.. 93. 1630-1637 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Takeno et al.: "Thermoregulatory and aerobic change after endurance training in a hypobaric Hypoxic and warm environment."J.Appl.Physiol.. 91. 1520-1528 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Nose et al.: "Exercise, nutrition, and Environmental Stress Vol.3"Cooper Publishing Group, Traverse City, MI. 1-283 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2005-04-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi