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2003 Fiscal Year Final Research Report Summary

Identification of molecules involved in inactivation of mast cells.

Research Project

Project/Area Number 13557040
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 内科学一般
Research InstitutionThe University of Tokyo

Principal Investigator

KITAMURA Toshio  The University of Tokyo, Institute of Medical Science, Professor, 医科学研究所, 教授 (20282527)

Project Period (FY) 2001 – 2003
Keywordsmast cell / NK receptor / allergy / paired Ig receptor / phosphatase / signal sequence trap
Research Abstract

We searched for secreted and membrane proteins from cultured bone marrow-derived mouse mast cells using retrovirus-mediated signal sequence trap method SST-REX. From this screening, we identified a novel membrane protein harboring a homology with inhibitory NK receptors. This protein harbors a single immunoglobulin like domain in the extracellular domein and three or four ITIM inhibitory motifs in the intracellular domain, and was designated as LMIRl that stands for Jeukocyte-associated mono Ig receptor-l. From the data base search, we also identified LMIR-2-6 that resemble LMIR1, and isolated full-length cDNAs for these proteins. LMIRl and 3 harbors ITIM motifs in the intracellular domain, and upon ligation, they induced phosphorylation of phosphatases SHP1, SHP2, and SHIP, thereby inducing inhibitory signals. On the other hand, LMIR2, 4, 5, and 6 have short intracellular domain, and associate with activating receptors including DAP10, DAP12 and FcRg through the transmembrane domains. We have developed monoclonal antibodies against LMIR-1-6. To clarify the physiological roles of these molecules especially in the control of mast cell activation, we are now trying to identify the ligands for LMIR1 and 3, and to generate the knockout mice for LMIRI-3.

  • Research Products

    (92 results)

All Other

All Publications (92 results)

  • [Publications] Kagami, S.: "Role of Stat5a in T Helper Cell Differentiation."Blood. 97. 2358-2365 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirose, K.: "MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody."J.Biol.Chem.. 276. 5821-5828 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamizono, S.: "The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2."J.Biol.Chem.. 276. 12530-12538 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawashima, T.: "STAT5 induces macrophage differentiation of M1 leukemia cells through activatiion of IL-6 production mediated by NF-κB p65."J.Immunol.. 167. 3652-3660 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tonozuka, Y.: "Molecular cloning of a human novel type I cytokine receptor related to Deltal."Cytogenetics and Cell Genetics. 93. 23-25 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishido, M.: "Cholesterol requirement for receptor transport from multivesicular late endosomes to the Golgi."J.Cell Science. 114. 1965-1976 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tullin, E.E.: "A novel secreted form of immune suppressor factor with high homology to vacuolar ATPase identified by forward genetic approach of functional screening based on cell proliferation."J.Biol.Chem.. 276. 27519-27526 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura, M.: "Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene."Immunity. 15. 275-287 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Senga, T.: "JAK/Stat3 dependent activation of RalGDS/Ral pathway in M1 mouse myeloid leukemic cells."J.Biol.Chem.. 276. 32678-32681 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Frasor, J.: "Differential roles for Stat5α and Stat5β in prolactin stimulation of estrogen receptor a and b transcription."Molecular Endcrinol.. 15. 2172-2181 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto, S.: "Proleferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord."Exp.Neurol.. 172. 115-127 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tokoro, Y.: "Molecular cloning and characterization of mouse tspan-3, a novel member of the tetraspanin superfamily, expressed on resting dendritic cells."Biochem.Biophys.Res.Commun.. 288. 178-183 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamashita, Y.: "Sak serine-threonine kinase acrts as an effector of Tec tyrosine kinase."J.Biol.Chem.. 276. 39012-39020 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ueno, M.: "Identification of an embryonic dorsal aorta specific gene, endomucin, and its inhibitory activity on cell adhesion."Biochem.Biophys.Res.Commun.. 287. 501-506 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ye, S.K.: "The IL-7 receptor controls the accessbility of the TCRγ locus by Stat5 and histone acetylation."Immunity. 15. 813-823 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto, S.: "Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord."J.Neurosci.. 21. 9814-9823 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Arakawa, M.: "Negamycin can restore dystrophin in mdx skeletal muscle."Acta.Myologica. 20. 154-158 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitamura, T.: "Role of MgcRacGAP/CYK4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation."Cell Structure and Function. 26. 645-651 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tulin, E.E.: "Genetic approach and phenotype-based complementation screening for identification of stromal cell-derived proteins involved in cell proliferation."Exp.Cell Res.. 272. 23-31 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tulin, E.E.: "Inhibition of human endothelial cell proliferation by ShIF, a vacuolar H+-ATPAse-like protein."Oncogene. 21. 844-848 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sai, X.: "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein."J.Biol.Chem.. 277. 12915-12920 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nosaka, T.: "Pim-1 expression is sufficient to induce cytokine independence in murin hematopoietic cells, but is dispensable for BCR-ABL-mediated transformation."Exp.Hematol.. 30. 697-702 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura, T.: "Cytokine receptor common β subunit-mediated STAT5 activation confers NFκB activation in murine pro B cell line Ba/F3 cells."J.Biol.Chem.. 277. 6254-6265 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Perez, O.D.: "Activation of the PKB/AKT pathway by ICAM-2."Immunity. 16. 51-65 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagai, Y.: "Essential role of MD-2 in LPS responsiveness and TLR4 distribution."Nat.Immunol.. 3. 667-672 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gugasyan, R.: "Dok-related protein negatively regulates T cell development is RasGTPase activating protein and Nck docking sites."J.Cell.Biol.. 158. 115-125 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Stoeclin, G.: "Functional cloning of BRF-1, a regulator of ARE-dependent mRNA turnover."EMBO J.. 21. 4709-4718 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Komano, H.: "A new functional screening system for the identification of DNA encoding a regulator of γ-cleavage."J.Biol.Chem.. 277. 39627-39633 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ezoe, S.: "GATA-2 affects cytokine-dependent growth of hematopoietic cells through accumulation of p21WAF1 and p27Kip1 proteins."Blood. 100. 3512-3520 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yujiri, T.: "MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression."J.Biol.Chem.. 278. 3846-3851 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ozawa, T.: "A genetic approach to identifying mitochondrial proteins."Nat.Biotechnol.. 21. 287-293 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Minoshima, Y.: "Phosphorylation by Aurora B converts MgcRac GAP to a RhoGAP during cytokinesis."Dev.Cell. 4. 549-560 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nosaka, T.: "Mammalian twisted gastulation is essential for skeleto-lymphogenesis."Mol.Cell.Biol.. 23. 2969-2980 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitamura, T.: "Retrovirus-mediated gene transfer and expression cloning, powerful tools in functional genomics."Exp.Hematol.. 31. 1007-1014 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Bao, Y-C.: "Identification of a human cDNA sequence which encodes a novel membrane-associated protein containing a zinc metalloprotease motif."DNA Research. 10. 123-128 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murata, K.: "A novel tyrosine kinase inhibitor GTP14564 specifically inhibits constitutively active fms-like tyrosine kinase 3 through inactivation of STAT5."J.Biol.Chem.. 278. 32892-32898 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ueno, H.: "A stromal cell-derived membrane protein that supports hematopoietic stem cells."Nat.Immunol.. 4. 457-463 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisaoka, T.: "Expression of a member of tumor necrosis factor receptor superfamily, TROY, in the developing and the adult mouse brain."Brain Research. 143. 105-109 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takizawa, M.: "Requirement of gp130 signaling for the AGM hematopoiesis."Exp.Hematol.. 31. 283-289 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tahara, H.: "Reconstitution of CD8+T cells by retroviral transfer of the T-cell receptor ab chain genes isolated from a clonally expanded P815 infiltrating lymphocytes."J.Immunol.. 171. 2154-2160 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kumagai, H.: "Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells."Biochem.Byophys.Res.Commun.. 307. 719-729 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murata, K.: "Selective Cytotoxic Mechanism of GTP-14564, a Novel Tyrosine Kinase Inhibitor in Leukemia Cells Expressing a Constitutively Active Fms-like Tyrosine Kinase 3 (FLT3)."J.Biol.Chem.. 278. 32892-32898 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishiyama, C.: "Functional analysis of PU.1 domains in monocyte-specific gene regulation."FEBS letters. 561. 63-68 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishiyama, C.: "Overproduction of PU.1 in mast cell progenitors : its effect on monocyte-and mast cell-specific gene expression."Biochem.Byophys.Res.Commun.. 313. 516-521 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikeda, Y.: "Vasorin, a novel TGF-β binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo."Proc.Natl.Acad.Sci.USA.. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishizama, H.: "Musculin, a novel skeletal muscle-derived secretary factor."J.Biol.Chem.. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kagami, S., Nakajima, H., Suto, A., Hirose, K., Suzuki, K., Morita, S., Kato, I., Saito, Y., Kitamura, T., Iwamoto, I.: "Role of Stat5a in T Helper Cell Differentiation."Blood. 97. 2358-2365 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirose, K., Kawashima, T., Iwamoto, I., Nosaka, T., Kitamura, T.: "MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody."J. Biol. Chem.. 276. 5821-5828 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamizono, S., Hanada, T., Yasukawa, H., Minoguchi, S., Kato, R., Minoguchi, M., Hattori, K., Morita, S., Kitamura, T., Kato, H., Nakayama, K., Yoshimura, A.: "The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2."J. Biol. Chem.. 276. 12530-12538 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawashima, T., Murata, K., Akira, S., Tonozuka, Y., Minoshima, Y., Feng, S., Kumagai, H., Tsuruga, H., Ikeda, Y., Asano, S., Nosaka, T., Kitamura, T.: "STAT5 induces macrophage differentiation of Ml leukemia cells through activation of IL-6 production mediated by NF-kB p65."J. Immunol.. 167. 3652-3660 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tonozuka, Y., Fujio, K., Sugiyama, T., Nosaka, T., Hirai, M., Kitamura, T.: "Molecular cloning of a human novel type I cytokine receptor related to Deltal."Cytogenetics and Cell Genetics. 93. 23-25 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishido, M., Yamamoto, A., Kitamura, T., Nagayama, K., Ohashi, M.: "Cholesterol requirement for receptor transport from multivesicular late endosomes to the Golgi."J.Cell. Science. 114. 1965-1976 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tulin, E.E., Onoda, N., Macda, M., Hasegawa, M., Nosaka, T., Nomura, H., Asano, S., Kitamura, T.: "A novel secreted form of immune suppressor factor with high homology to vacuolar ATPase identified by forward genetic approach of functional screening based on cell proliferation."J. Biol. Chem.. 276. 27519-27526 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura, M., Koseki, Y., Yamashita, M., Watanabe, N., Shimizu, C., Katsumoto, T., Kitamura, T., Taniguchi, M., Koseki, H., Nakayama, K.: "Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene."Immunity. 15. 275-287 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Senga, T., Iwamoto, T., Kitamura, T., Miyake, Y., Hamaguchi, M.: "JAK/Stat3 dependent activation of RalGDS/Ral pathway in Ml mouse myeloid leukemic cells."J. Biol. Chem.. 276. 32678-32681 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Frasor, J., Park, K-S., Byers, M., Telleria, C., Kitamura, T., Yu-Lee, L., Djiane, J., Park-Sarge, 0.-K., Gibori, G.: "Differential roles for Stat5 α and Statβ in prolactin stimulation of estrogen receptor a and b transcription."Molecular Endcrinol.. 15. 2172-2181 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto, S., Yamamoto, N., Kitamura, T., Nakamura, K., Nakafuku, M.: "Proleferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord."Exp. Neurol.. 172. 115-127 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tokoro, Y., Shibuya, K., Osawa, M., Tahara-Hanaoka, S., Iwama, A., Kitamura, T., Nakauchi, H., Shibuya, A.: "Molecular cloning and characterization of mouse tspan-3, a novel member of the tetraspanin superfamily, expressed on resting dendritic cells."Biochem. Biophys. Res. Commun.. 288. 178-183 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamashita, Y., Kaijigaya, S., Yoshida, K, Ueno, S., Ota, J., Ohmine, K., Ueda, M., Miyazato, A., Ohya, K., Kitamura, T., Ozawa, K., Mano, H.: "Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase."J. Biol. Chem.. 276. 39012-39020 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ueno, M., Igarashi, K., Kimura, N., Okita, K., Takizawa, M., Nobuhisa, I., Kojima, T., Kitamura, T., Morgan, S.M., Shiomura, T., Suda, T., Nakashima, K., Taga, T.: "Identification of an embryonic dorsal aorta specific gene, endomucin, and its inhibitory activity on cell adhesion."Biochem. Byophys. Res. Commun.. 287. 501-506 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ye, S.K., Agata, Y., Lee, H.C., Kurooka, H., Kitamura, T., Shimizu, A., Honjo, T., Ikuta, K.: "The IL-7 receptor controls the accessbility of the TCR γ locus by Stat5 and histone acetylation."Immunity. 15. 813-823 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto, S., Nagao, M., Kitamura, T., Nakatomi, H., Sugimori, M., Kosako, H., Yamamoto, N., Takebayashi, H., Weinmaster, G., Nakamura, K., Nakafuku, M.: "Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord."J.Neurosci.. 21. 9814-9823 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Arakawa, M., Nakayama, Y., Hara, T., Shiozuka, M., Takeda, S., Kaga, K., Kondo, S., Morita, S., Kitamura, T., Matsuda, R.: "Negamycin can restore dystrophin in mdx skeletal muscle."Acta Myologica. 20. 154-158 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitamura, T., Kawashima, T., Minoshima, Y., Tonozuka, Y., Hirose, K., Nosaka, T.: "Role of MgcRacGAP/CYK4 as a regulator of small GTPase Rho family in cytokinesis and cell differentiation."Cell Structure and Function. 26. 645-651 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tulin, E.E., Onoda, N., Hasegawa, M., Nosaka, T., Nomura, H., Kitamura, T.: "Genetic approach and phenotype-based complementation screening for identification of stromal cell-derived proteins involved in cell proliferation."Exp. Cell Res.. 272. 23-31 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tulin, E.E., Onoda, N., Hasegawa, M., Nomura, H., Kitamura, T.: "Inhibition of human endothelial cell proliferation by ShIF, a vacuolar H+-ATPAse-like protein."Oncogene. 21. 844-848 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sai, X., Kawamura, Y., Kokame, K., Yamaguchi, H., Shiraishi, H., Suzuki, R., Suzuki, T., Kawaichi, M., Miyata, T., Kitamura, T., De Strooper, B., Yanagisawa, K., Komano, H.: "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein."J. Biol. Chem.. 277. 12915-12920 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nosaka, T., Kitamura, T.: "Pim-1 expression is sufficient to induce cytokine independence in murin hematopoietic cells, but is dispensable for BCR-ABL-mediated transformation."Exp. Hematol.. 30. 697-702 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura, T., Ouchida, R., Kodarna, T., Kawashima, T., Watanabe, S., Morimoto, C., Kitamura, T., Tanaka, H.: "Cytokine receptor common β subunit-mediated STAT5 activation confers NFκB activation in murinepro B cell line Ba/F3 cells."J. Biol. Chem.. 277. 6254-6265 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Perez, 0.D., Kinoshita, S., Hitoshi, Y., Payan, D.G., Kitamura, T., Nolan, G.P., Lorens, J.: "Activation of the PKB/AKT pathway by ICAM-2."Immunity. 16. 51-65 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagai, Y., Akashi, S., Nagafuku, M., Ogata, M., Iwakura, Y., Akira, S., Kitamura, T., Kosugi, A., Kimoto, M., Miyake, K.: "Essential role of MD-2 in LPS responsiveness and TLR4 distribution."Nat. Immunol.. 3. 667-672 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gugasyan, R., Quilici, C., I, S.T., Grail, D., Verhagen, A.M., Roberts, A., Kitamura, T., Dunn, A.R., Lock, P.: "Dok-related protein negatively regulates T cell development ts RasGTPase activating protein and Nck docking sites."J. Cell Biol.. 158. 115-125 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Stoeclin, G., Colombi, M., Raineri, I., Leuenberger, S., Mallaun, M., Schmidlin, M., Gross, B., Lu, M., Kitamura, T., Moroni, C.: "Functional cloning of BRF-1, a regulator of ARE-dependent mRNA turnover."EMBO J.. 21. 4709-4718 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Komano, H., Kawamura, Y., Shiraishi, H., Sai, X., Suzuki, R., Kawaichi, M., Kitamura, T., Yanagisawa, K.: "A new functional screening system for the identification of DNA encoding a regulator of γ-cleavage."J. Biol. Chem.. 277. 39627-39633 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ezoe, S., Matsumira, I., Ishihara, K., Minegishi, N., Takahashi, S., Mchii, T., Kitamura, T., Yamamoto, M., Enver, T., Kanakura, Y.: "GATA-2 affects cytokine-dependent growth of hematopojetic cells through accumulation of p21 WAF1 and p27Kipl proteins."Blood. 100. 3512-3520 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yujiri, T., Nawata, R., Takahashi, T., Sato, Y., Tanizawa, Y., kitamura, T., Oka, Y.: "MEK kinase I interacts with focal adhesion kinase and regulates insulin receptor substrate-l expression."J. Biol. Chem.. 278. 3846-3851 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ozawa, T., Sako, Y., Sato, M., Kitamura, T., Umezawa, Y.: "A genetic approach to identifying mitochondrial proteins."Nat. Biotechnol.. 21. 287-293 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Minoshima, Y., Kawashima, T., Hirose, K., Tonozuka, Y., Kawajiri, A., Bao, Y-C., Deng, X., Tatsuka, M., Narumiya, S., May, W.S.Jr., Nosaka, T., Semba, K., Inoue, T., Satoh, T., Inagaki, M., Kitamura, T.: "Phosphorylation by Aurora B converts MgcRacGAP to a RhoGAP during cytokinesis."Dev. Cell. 4. 549-560 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nosaka, T., Morita, S., Kitamura, H., Nakajima, H., Shibata, F., Morikawa, Y., Kataoka, Y., Ebihara, Y., Kawashima, T., Itoh, T., Ozaki, K., Senba, B., Tsuji, K., Makishima, F., Yoshida, N., Kitamura, T.: "Mammalian twisted gastulation is essential for skeleto-lymphogenesis."Mol. Cell. Biol.. 23. 2969-2980 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitamura, T., Koshino, Y., Shibata, F., Nakajima, H., Nosaka, T., Kumagai, H.: "Retrovirus-mediated gene transfer and expression cloning, powerful tools in functional genomics."Exp. Hematol.. 31. 1007-1014 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Bao, Y-C., Tsuruga, H., Hirai, M., Kitamura, T., Kumagai, H.: "Identification of a human cDNA sequence which encodes a novel membrane-associated protein containing a zinc metalloprotease motif."DNA Research. 10. 123-128 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, K., Kumagai, H., Kawashima, T., Irie, M., Nakajima, H., Tamitsu, K., Nosaka, T., Asano, S., Kitamura, T.: "A novel tyrosine kinase inhibitor GTP14564 specifically inhibits constitutively active fms-like tyrosine kinase 3 through inactivation of STAT5."J. Biol, Chem.. 278. 32892-32898 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ueno, H., Sakita-Ishikawa, M., Morikawa, Y., Nakano, T., Kitamura, T., Saito, M.: "A stromal cell-derived membrane protein that supports hematopoietic stem cells."Nat. Immunol.. 4. 457-463 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hisaoka, T., Morikawa, Y., Kitamura, T., Semba, E.: "Expression of a member of tumor necrosis factor receptor superfamily, TROY, in the developing and the adult mouse brain."Brain Research. 143. 105-109 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takizawa, M., Nobuhisa, I., Igarashi, K., Ueno, M., Nakashima, K., Kitamura, T., Taga, T.: "Requirement of gp130 signaling for the AGM hematopolesis."Exp. Hematol.. 31. 283-289 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tahara, H., Fujio, K., Araki, Y., Setoguchi, K., Misaki, Y., Kitamura, T., Yamamoto, K.: "Reconstitution of CD8+ T cells by retroviral transfer of the T-cell receptor ab chain genes isolated from a clonally expanded P815 infiltrating lymphocytes."J. Immunol.. 171. 2154-2160 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kumagai, H., Oki, T., Tamitsu, K., Feng, S-Z., Ono, M., Nakajima, H., Bao, Y-C., Kawakami, Y., Nagayoshi, K., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Kawakami, T., Kitamura, T.: "Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells."Biochem. nyophys. Res. Commun.. 307. 719-729 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, K., Kumagai, H., Kawashima, T., Tamistu, K, Irie, M., Nakajima, H., Suzu, S., Shibuya, M., Kamihara, S., Nosaka, T., Asano, S., Kitamura, T.: "Selective Cytotoxic Mechanism of GTP-14564, a Novel Tyrosine Kinase Inhibitor in Leukemia Cells Expressing a Constitutively Active Fins-like Tyrosine Kinase 3 (FLT3)."J. Biol. Chem.. 278. 32892-32898 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishlyama, C., Nishlyama, M., Ito, T., Masaki, S., Masuoka, N., Yamane, H., Kitamura, T., Ogawa, H., Okumura, K.: "Functional analysis of PU.1 domains in monocyte-specific gene regulation."FEBS letters. 561. 63-68 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishiyama, C., Nishiyama, M., Ito, T., Masaki, S., Maeda, K., Masuoka, N., Yamane, H., Kitamura, T., Ogawa, H., Okumura, K.: "Overproduction of PU.1 in mast cell progenitors: its effect on monocyte-and mast cell-specific gene expression."Biochem. Biophys. Res. Commun.. 313. 516-521 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikeda, Y., Imai, Y., Kumagai, H., Nosaka, T., Morikawa, Y., Hisaoka, T., Manabe, I., Maemura, K., Nakaoka, T., Imamura, T., Miyazono, K., Komuro, I., Nagai, R., Kitamura, T.: "Vasorin, a novel TGF-β binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo."Proc. Nati. Acad. Sci. USA. (in press.). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishizawa, H., Matsuda, M., Yamada, Y., Kawai, K., Suzuki, B., Makishima, M., Kitamura, T., Shimomura, I.: "Musculin, a novel skeletal mescie-derived secretary factor."J. Biol. Chen. (in press.). (2004)

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Published: 2005-04-19  

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