2003 Fiscal Year Final Research Report Summary
Identification and regulation of differentiation In bone marrow -derived vascular progenitor cells
| Project/Area Number |
13557061
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HIRATA Yasunobu The University or Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (70167609)
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| Co-Investigator(Kenkyū-buntansha) |
SATA Masataka The University or Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (80345214)
SUZUKI Etsu The University or Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (40313134)
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| Project Period (FY) |
2001 – 2003
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| Keywords | neointima / arteriosclerosis / stem cell / bone marrow / VSMC / LacZ |
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| Research Abstract |
We have suggested that bone marrow-derived progenitor cells may contribute to the pathogenesis of vascular diseases. On the other hand, It was reported that bone marrow cells do not participate substantially in vascular remodeling in other experimental systems. in this study, three distinct types of mechanical vascular injuries were induced in the same mouse whose bone marrow had been reconstituted with that of GFP or LacZ mice. All injuries are known to cause smooth muscle cell (SMC) hyperplasia. At 4 weeks after wire-mediated endovascular injury, a significant number of the neointlmal and medial cells derived from bone marrow. In contrast, marker-positive cells were seldom detected in the lesion induced by perivascular cuff replacement. There were only a few bone marrow-derived cells in the neointima after ligation of the common carotid artery. These results indicate that the origin of Intimal cells is diverse and that contribution of bone marrow-derived cells to neointlmal hyperpiasia depends on the type of model.
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Research Products
(20 results)
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[Publications] Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Kakoki M, Nagata D, Hayakawa H, Satonaka H, Sata M, Tojo A, Suzuki E, Kangawa K, Matsuo H, Kitamura T, Nagai R: "Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury : studies on transgenic/knockout mice of adrenomedullin gene."Circ Res. 90. 657-663 (2002)
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[Publications] Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S.Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sota M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kuraboyashi M, Nagai R: "Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling."Nat Med. 8. 856-863 (2002)
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[Publications] Abe M, Sata M, Nishimatsu H, Nagata D, Suzuki E, Terauchi Y, Kadowaki T, Minamino N, Kangawa K, Matsuo H, Hirata Y, Nagai R: "Adrenomedullin augments collateral development in response to acute ischemia.."Biochem Biophys Res Commun. 306. 10-15 (2003)
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[Publications] Niu P.Shindo T, Iwata H, limuro S, Tckeda N, Zhang Y, Ebihara A, Suematsu Y, Kangawa K, Hirata Y, Nagai R: "Protective Effects of Endogenous Adrenomedullin on Cardiac Hypertrophy, Fibrosis, and Renal Damage."Circulation. (In press).
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「研究成果報告書概要(欧文)」より
