2002 Fiscal Year Final Research Report Summary
CD36 AS A GENETIC BACKGROUND FOR METABOLIC SYNDROME AND ATHEROSCLEROTIC CARDIOVASCULAR DISEASE
| Project/Area Number |
13557093
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 展開研究 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | OSAKA UNIVERSITY |
|---|
Principal Investigator |
SHIZUYA Yamashita Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (60243242)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ITO Tetsu Fujireblo inc., Diagnostic Research Lab, Researcher, 医薬研究所, 主任研究員
TOMIYAMA Yoshiaki Osaka University Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (80252667)
HIRANO Ken-ichi Osaka University Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (30332737)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Keywords | Apolipoprotein B48 / Metabolic syndrome / Hyperlipidemia / CD36 / Genetic background |
|---|
| Research Abstract |
CD36, originally identified as glycoprotein IV on platelets, is an 88 kDa integral membrane protein that has multiple ligands and is expressed in the cardiovascular system (ie, blood vessel walls and the heart) as well as adipose tissues and skeletal muscles. Human genetic deficiency is relatively frequent in Asian and African populations. The investigation into the pathophysiology of this disorder has shown that CD36 may play an important role as a major scavenger receptor for oxidized low density lipoproteins and as a crucial transporter for long chain fatty acids. The CD36 deficiency may be related to the phenotypic expression of the "metabolic syndrome", which is frequently associated with atherosclerotic cardiovascular diseases. These data raised the possibility that CD36 deficiency might be an important genetic background for these human atherosclerotic cardiovascular disease.
|
