2002 Fiscal Year Final Research Report Summary
Establishment of Simple Method for Screening of Teratogenic Steroids in Early Development of Vertebrates
| Project/Area Number |
13558085
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Functional biochemistry
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| Research Institution | Sapporo School of The Arts (2002)
Tokyo Metropolitan College (2001) |
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Principal Investigator |
NISHINO Hideaki Sapporo School of The Arts, Associate Professor, インダストリアルデザイン学科, 助教授 (40198487)
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| Project Period (FY) |
2001 – 2002
|
| Keywords | Sonic hedgehog / cholesterol / steroid / teratogen / development |
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| Research Abstract |
Antibodies prepared in this study showed positive reaction only when the antigen, recombinant sonic hedgehog protein, was processed to mature form having new carboxy-terminus by incubation with cholesterol. The other steroids can be screened using this antibodies whether they process sonic hedgehog protein or not, that is, perturb the normal process of early development of vertebrates or not.
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