Development of a Multi-turn Time of Flight Mass Spectrometer for the analysis of organic compounds

2002 Fiscal Year Final Research Report Summary

• Project/Area Number: 13559005
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 展開研究
• Research Field: 広領域
• Research Institution: Osaka University
• Principal Investigator: ISHIHARA Morio Osaka University, Grad.School of Sci., assistant professor, 大学院・理学研究所, 助教授 (30294151)
• Co-Investigator(Kenkyū-buntansha): ARAKAWA Ryuichi Kansai Univ., Fac.of Eng., professor, 工学部, 教授 (00127177) ; TOYODA Michisato Osaka University, Grad.School of Sci., assistant, 大学院・理学研究科, 助手 (80283828) ; KATAKUSE Itsuo Osaka University, Grad.School of Sci., professor, 大学院・理学研究科, 教授 (10028235) ; KANMEI Yoshihiro JEOL Lid., Manager, 基礎研究部, 室長(研究職) ; WADA Yoshinao Osaka Medical Resaerch institute for Maternal and Child Health., Director, 研究所, 所長(研究職) (00250340)
• Project Period (FY): 2001 – 2002
• Keywords: TOF / MS / High mass organic molecule / Multi-turn TOF / MS

Research Abstract

In the first step, we developed a new Multi-turn Time of Flight Mass Spectrometer named 'MULTUM II' consisting of only 4 troidal electric sectors. A new electric power supply for. the electric sector and an electron ionization source were constructed. The efficiency of the ion detector was tested. As a result, we can detect the ion beam after 200 cycles it was conformed that the new instrument has stable ion orbit as 'MULTUM', the instrument consisting of 8 Qlenses and 4 cylindrical electric sectors
In the next step, we introduce new ion sources for ionizing organic compounds. An ESI ion source was developed and tested with a, magnetic sector, instrument. For connecting this with TOF/MS, an ion trap was developed
A MALDI ion source was newly developed. An FAB source : for commercial instruments (JEOL Ltd) was modified for the TOF/MS. The performance was tested by using Angiotensin I as a sample. The mass resolution 70,000 was obtained

Research Products

• [Publications] D.Okumura, M.Toyoda, M.Ishihara, I.Katakuse: "A Simple Multi-Turn Time of Flight Mass Spectrometer 'MULTUM II'"J.Mass Spectrom.Soc.Jpn.. 51. 349-353 (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] M.Toyoda, D.Okumura, M.Ishihara, I.Katakuse: "Multi-turn time-of-flight mass spectrometers with electrostatic sectors."J.Mass Spectrom.. 38. 1125-1142 (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Daisuke Okumura^*, Michisato Toyoda, Morio Ishihara, Itsuo Katakuse: "Application of a Multi-Turn Time-of-Flight Mass Spectrometer, 'MULTUM II',to oraganic compounds ionized by MALDI"J.Mass.Spectrom. 39. 86-90 (2004)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Daisuke OKUMURA^*, Michisato TOYDA, Morio ISHIHARA, Itsuo KATAKUSE: "A compact sector-type multi-turn Time-of-Flight Mass Spectrometer 'MULTUM II'"Nucl.Instrum.Meth.,Vol 519/1-2 pp 331-337(2004). 519. 331-337 (2004)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Kousuke KUMONDAI, Michisato TOYODA, Kenichi IWAMOTO, Daisuke OKUMURA, Morio ISHIHARA, Masahiro KIMURA, Itsuo KATAKUSE: "Development of an Ion Trap for an Ion Source of a Time-of-Flight Mass Spectrometer"J.Mass Spectrom.Soc.Jpn.,50. 50. 217-222 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] D.Okumura, M.Toyoda, M.Ishihara, I.Katakuse: "A Simple Multi-Turn Time of Flight Mass Spectrometer 'MULTUM II'"J.Mass Spectrom.Soc.Jpn.. 51, 2. 349-353 (2003)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] M., Toyoda, D.Okumura, M.Ishihara, I.I.Katakuse: "Multi-turn time-of-flight mass spectrometers with electrostatic sectors"J.Mass Spectrom.. 38. 1125-1142 (2003)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Daisuke Okumura^*, Michisato Toyoda, Morio Ishihara, Itsuo Katakuse: "Application of a Multi-Turn Time-of-Fligh Mass Spectrometer, 'MULTUM II', to organic compounds ionized"J.Mass.Spectrom.. 39. 86-90 (2004)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Daisuke OKUMURA^*, Michisato TOYODA, Morio ISHIHARA, Itsuo KATAKUSE: "A compact sector-type multi-turn Time-of Flight Mass Spectrometer 'MULTUM II'"Nucl.Instrum.Meth.. Vol 519/1-2. 331-337 (2004)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kousuke KUMONDAI, Michisato TOYODA, Kenichi IWAMOTO, Daisuke OKUMURA, Morio ISHIHARA, Masahiro KIMURA, Itsuo KATAKUSE: "Development of an Ion Trap for an Ion Source of a Time-of-Flight Mass Spectrometer"J.Mass Spectrom.Soc.Jpn.. 50. 217-222 (2002)
  • Description: 「研究成果報告書概要(欧文)」より