2002 Fiscal Year Final Research Report Summary

Survery and evaluation of anti-malaria plant in Indenesia

Research Project

Project/Area Number	13574013
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	海外学術
Research Field	Bioproduction chemistry/Bioorganic chemistry
Research Institution	Hokkaido University
Principal Investigator	YOSHIHARA Teruhiko Graduate School of Agriculture Professor, 大学院・農学研究科, 教授 (90002071)
Co-Investigator(Kenkyū-buntansha)	YAMATO Osamu Graduate School of Veterinary Lecturer, 大学院・獣医学研究科, 講師 (80261337) MAEDA Yoshimitsu Graduate School of Veterinary Professor, 大学院・獣医学研究科, 教授 (40002084) TAHARA Satoshi Graduate School of Agriculture Professor, 大学院・農学研究科, 教授 (50001475) KATAKURA Ken Gunma University, School of Medical Associate Professor, 医学部, 助教授 (10130155) SUZUKI Mamoru Gunma University, School of Medical Professor, 医学部, 教授 (60056033)
Project Period (FY)	2001 – 2002
Keywords	Indonesea / Kalimantan / Sumatera / malaria / anti-malarial plant / Babesia gibsoni
Research Abstract	The first survey : Aug 3, 〜Aug 7, 2001 Survey was done at the place near Palangkaraya in Central Kalimantan. Twenty seven anti-malaria plants were collected. The determination of species was done by the researchers of LIPI. The second survey : Dec 14, 〜Dec 23, 2002 Survey was done at the place near Palembang and Lampung in South Sumatera. Eveven plants were collected. Anti Babesia compounds were isolated from the plants according to the bioassay of Babesia gibsoni. Phyllanthus niruri : Pentahydroxyxanthon, Ellagic acid glucopyranoside, Arcangelisia flava : Berberine, 20-Hydroxy ecdisone Peronema canescens : Peronemin A3, Quercetin glucopyranoside Garcinia celebica : Catechine, Catechine dimer Shorea balangeran : Vaticanol A, B, G Garacinia rigida : Mangostin Curcuma zedoaria : Zedoalactone B, C Cinnamomum sintoc : 1-allyl-3,4-dimethyl benzene, 1-allyl-3,5-dimethoxy phenol, euqenol, innamaldehyde, cinnamic acid, cinnamyl alcohol, 3-(4-hydroxy-3-methoxy phenyl)-propenal, vanillin, sitosterol, 2,3-Bis-(4-hydroxy-3-methoxy-benzyl)-butane-1,4-diol) Berberin from A-flava and mangostin from G-rigida showed the high anti-malaria adtizities. These two plants are effutive, as medical plants.