| Co-Investigator(Kenkyū-buntansha) |
TERAO Hideo OITA MEDICAL UNIVERSITY, DEPARTMENT OF HEALTH SCIENCE CENTER, PROFESSOR, 保健管理センター, 教授 (10128192)
HAMAGUCHI Kazuyuki OITA MEDICAL UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (60180931)
SAKATA Toshiie NAKAMURA GAKUEN UNIVERSITY, PROFESSOR, 栄養科学研究部, 教授 (50037420)
AONO Hirohi OITA MEDICAL UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESOR, 医学部, 助教授 (80150936)
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| Research Abstract |
The human glycoprotein PC-1 codon Q121 allele has been correlated with insulin resistance, but not with type 2 diabetes or obesity. We investigated the prevalence of PC-1 Q121 in the Dominican Republic population (755 subjects studied), and whether this variant is associated with insulin resistance, obesity or type 2 diabetes. The prevalence of PC-1 Q121 was high compared to other populations. The proportions of genotypes detected were KK 21.6%, KQ 48.3%, and QQ 30.1%. This compares to 〜74%, 〜24% and 〜2% in other populations. Among non-obese, non-diabetic subjects, the insulin response of KQ (Pz0.027) and QQ (Pz0.031) subjects was greater during the oral glucose tolerance test than the KK subjects, while plasma glucose profiles were. comparable. The Q allele was more prevalent in obese type 2 diabetics than in controls (Th0.026, 0R1.56). Multiple regression analysis after adjusting for age, gender and BMI showed the QQ genotype was associated with type 2 diabetes (Pz0.043, 0R2.74) but not obesity (P0.068). These results indicate that the PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic, contributing to both insulin resistance and type 2 diabetes.
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