2003 Fiscal Year Final Research Report Summary
Study of functionalized gadolinium chelates as magnetic resonance imaging contrast agents
| Project/Area Number |
13640586
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
機能・物性・材料
|
|---|
| Research Institution | Hiroshima International University |
|---|
Principal Investigator |
USUI Shuji Hiroshima International University, Faculty of Health Sciences, Professor, 保健医療学部, 教授 (20160252)
|
|---|
| Project Period (FY) |
2001 – 2003
|
| Keywords | magnetic resonance imaging / contrast agents / gadolinium chelates / shiff's base / salicylaldehyde derivatives / relaxation time / gel phantom |
|---|
| Research Abstract |
Magnetic resonance imaging (MRI) is an important modality in clinical diagnosis. To enhance tissue contrasts, contrast agents based on gadolinium chelates have been used, however, they cannot always distinguish between lesions and normal parts. A purpose of this study is to develop contrast agents having a high tissue or lesion selectivity. Since it is difficult to selectively introduce functional groups onto diethylenetriaminepentaacetic acid (DTPA) or tetraazacyclododecanetetraacetic acid (DOTA) skeleton, the shiff's bases synthesized from benzaldehyde derivatives and polyamines were used in this study.
Syntheses of three types of chelates are as follows: Condensation of salicylaldehyde derivative and diethylenetriamine gave the corresponding Shiff's base, which was then treated with equimolecular amount of bromoacetate in a basic condition to yield the monoacetate. The imine double bonds were reduced by sodium borohydride and the resulting triamine was hydrolyzed to give the desired product (1).Similarly, starting from p-substituted benzaldehyde and diethylenetriamine, reduction of the Shiff's base and then carboxymethylation of the amine gave the corresponding triacetic acid derivative (2).Furthermore, condensation of salicylaldehyde derivative and tris(2-aminoethyl)amine gave the triarmed chelate (3).
Syntheses of gadolinium complexes of the chelates (1-3) and measurements of the magnetic properties are now in progress.
|
