2002 Fiscal Year Final Research Report Summary
STUDIES ON THE EFFECT OF PHOSPHORYLATION BY A KINASE
| Project/Area Number |
13660091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
応用微生物学・応用生物化学
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
TAMAKI Hisanori GRADUATE SCHOOL OF BIOSTUDIES, KYOTO UNVERSITY, INSTRUCTOR, 生命科学研究科, 助手 (20212045)
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| Project Period (FY) |
2001 – 2002
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| Keywords | Akinese / phosphorylation / cell growth / signal transduction / yeast |
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| Research Abstract |
Protein phosphorylation is known to play a central role in signal transduction pathways in the cell. A kinase(cAMP dependent protein kinase) which is conserved from yeast to higher eukaryotes plays very important roke in cell signaling. In the yeast A kinase is activated by the increase level of cAMP in the cell and activates cell growth. However the target proteins which can be phosphorylated by A kinase and accelerate cell growth has not been clarified.
In this project, identification of target proteins which is phosphorylated by A kinase was examined and some target proteins were identified in the yeast Saccharomyces cerevisiae.
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[Publications] Hong, J., Tamaki, H., Akiba, S., Yamamoto, K., and Kumagai, H.: "Cloning of a gene encoding a highly stable endo-b-1,4-glucanase from Aspergillus niger and its expression in yeast"J. Bioscience and Bioeng.. 92. 434-441 (2000)
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