2001 Fiscal Year Annual Research Report

Na/H交換阻害薬およびNa/Ca交換阻害薬の虚血再灌流不整脈に対する作用

Research Project

Project/Area Number	13670081
Research Institution	山梨医科大学
Principal Investigator	橋本敬太郎山梨医科大学, 医学部, 教授 (10004665)
Co-Investigator(Kenkyū-buntansha)	小森貞嘉山梨医科大学, 医学部, 教授 (30162069)
Keywords	Na / H交換 / Na / Ca交換 / 不整脈 / 心筋虚血 / 心臓突然死 / 不整脈モデル
Research Abstract	新しい選択的なNa/H交換機構の阻害薬として、本年度はFR168888が従来の阻害薬と同様に丸ごとの動物での抗不整脈作用があるかを検討し,論文として掲載出来た。橋本と小森はFR168888(0.3-10mg/kg)が、ラットにおいて、虚血後に投与しても、また再潅流と同時に投与しても有効であることを示し、さらに虚血中に低下する血圧を上昇させる従来のNa/H交換阻害薬になかった良い作用も認められた。またNa/Ca交換機構の阻害薬として、新規大阪大学で開発された薬物につきイヌの虚血再潅流不整脈について検討したが、既に報告されているラットの脳虚血障害改善作用に似た証明が出来なかった。現在用量、投与時期などを含め再実験を計画している。従来我々が同様のNa/Ca交換阻害薬KB-R7039での作用と似ており、Na/Ca交換阻害薬には生体位では作用が無いことを示している可能性もある。

Research Products

(9 results)

All Other

All Publications (9 results)

[Publications] Takahara A. et al.: "Cardiovascular action of a cardioselective Ca^<2+> channel blocker AH-1058 in conscious dogs assessed by telemetry"Euro. J. Pharmacol. 413. 101-108 (2001)
[Publications] Takahara A. et al.: "Utilization of telemetry system to assess the cardoiovascular profile of AH-1058, a new cardioselective Ca^<2+> channel blocker, in conscious dogs"Jpn. J. Pharmacol. 85. 331-334 (2001)
[Publications] Homma N, et al.: "Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes : Comparison with mexiletime and disopyramide"Jpn. J. Pharmacol. 86. 23-31 (2001)
[Publications] Miyamoto S, et al.: "Slowing Na^+ channel inactivation prolongs QT interval and aggravates adrenaline-induced arrhythmias"Jpn. J. Pharmacol. 86. 114-119 (2001)
[Publications] Sugiyama A. et al.: "Electropharmacologic effects of a new phosphodiesterase III inhibitor, toborinone(OPC-18790), assessed in an in vivo canine model"J. Cardiovasc. Pharmacol. 38. 268-277 (2001)
[Publications] Takahara A. et al.: "In vivo antiarrhythmic profile of AP-792 assessed in different canine arrhythmia models"Jpn. J. Pharmacol. 87. 21-26 (2001)
[Publications] Sugiyama A. et al.: "Acute electropharmacological effects of intravenously administered amiodarone assessed in the in vivo canine model"Jpn. J. Pharmacol. 87. 74-82 (2001)
[Publications] Noguchi K, et al.: "Effects of HNS-32, a novel antiarrhythmic agent, on guinea-pig myocardium"Pharmacology. 64. 36-42 (2002)
[Publications] Zhu BM et al.: "Inhibitory effects of pre-ischemic and post-ischemic treatment with FR 168888, a new Na^+/H^+ eschange inhibitor, on reperfusion-induced ventricular arrhythmias in anesthetized rat"Jpn. J. Pharmacol. 88. 93-99 (2002)

2001 Fiscal Year Annual Research Report

Na/H交換阻害薬およびNa/Ca交換阻害薬の虚血再灌流不整脈に対する作用

Principal Investigator

橋本 敬太郎 山梨医科大学, 医学部, 教授 (10004665)

Research Products

[Publications] Takahara A. et al.: "Cardiovascular action of a cardioselective Ca^<2+> channel blocker AH-1058 in conscious dogs assessed by telemetry"Euro. J. Pharmacol. 413. 101-108 (2001)

[Publications] Takahara A. et al.: "Utilization of telemetry system to assess the cardoiovascular profile of AH-1058, a new cardioselective Ca^<2+> channel blocker, in conscious dogs"Jpn. J. Pharmacol. 85. 331-334 (2001)

[Publications] Homma N, et al.: "Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes : Comparison with mexiletime and disopyramide"Jpn. J. Pharmacol. 86. 23-31 (2001)

[Publications] Miyamoto S, et al.: "Slowing Na^+ channel inactivation prolongs QT interval and aggravates adrenaline-induced arrhythmias"Jpn. J. Pharmacol. 86. 114-119 (2001)

[Publications] Sugiyama A. et al.: "Electropharmacologic effects of a new phosphodiesterase III inhibitor, toborinone(OPC-18790), assessed in an in vivo canine model"J. Cardiovasc. Pharmacol. 38. 268-277 (2001)

[Publications] Takahara A. et al.: "In vivo antiarrhythmic profile of AP-792 assessed in different canine arrhythmia models"Jpn. J. Pharmacol. 87. 21-26 (2001)

[Publications] Sugiyama A. et al.: "Acute electropharmacological effects of intravenously administered amiodarone assessed in the in vivo canine model"Jpn. J. Pharmacol. 87. 74-82 (2001)

[Publications] Noguchi K, et al.: "Effects of HNS-32, a novel antiarrhythmic agent, on guinea-pig myocardium"Pharmacology. 64. 36-42 (2002)

[Publications] Zhu BM et al.: "Inhibitory effects of pre-ischemic and post-ischemic treatment with FR 168888, a new Na^+/H^+ eschange inhibitor, on reperfusion-induced ventricular arrhythmias in anesthetized rat"Jpn. J. Pharmacol. 88. 93-99 (2002)

橋本敬太郎山梨医科大学, 医学部, 教授 (10004665)