2002 Fiscal Year Final Research Report Summary
Molecular and Clinicopathologic Significance of Gene Alteration Associated with MALT Lymphoma
| Project/Area Number |
13670185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nagoya City University |
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Principal Investigator |
INAGAKI Hiroshi Nagoya City University, Graduate School of Medical Sciences, Associated Professor, 大学院・医学研究科, 助教授 (30232507)
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| Project Period (FY) |
2001 – 2002
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| Keywords | MALT lymphoma / API2-MALT1 fusion / multiplex RT-PCR / clinicopathologic study / lung / thymus / skin / BCL10 |
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| Research Abstract |
API2-MALT1 fusion gene, cloned from t(11;18)(q21;q21) chromosomal translocation, is a gene abnormality specific to extranodal marginal zone B-cell lymphoma of mucosal-associated lymphoid tissue (MALT). However, the clinicopathologic significance of this chimeric gene remains to be clarified. We have developed a very sensitive multiplex RT-PCR assay for the API2-MALT1 fusion transcript using paraffin materials as a source of RNA, and enabled a large cohort study on this gene abnormality. Our data of a large series of pulmonary MALT lymphoma suggest that the API2-MALT1 fusion may be a causative gene abnormality unrelated to autoimmune disease. In addition, this alteration may define a homogeneous MALT lymphoma subtype that is clinically more indolent and histologically more "typical". Our observation that API2-MALT1 fusion is independence of autoimmune disease is further supported by the data obtained from the study of thymic MALT lymphoma. Aberrant nuclear BCL10 expression may have a possible role as a tool to screen for this API2-MALT1 fusion in pulmonary MALT lymphoma, but this is not the case with cutaneous MALT lymphoma. Case of rare esophageal and ureteral MALT lymphomas have been reported.
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[Publications] Inagaki H, Chan JKC, Ng JWM, Okabe M, Yoshino T, Okamoto M, Ogawa H, Matsushita H, Yokose T, Matsuno Y, Nakamura N, Nagasaka T, Ueda R, Eimoto T, and Nakamura S.: "Primary Thymic Extranodal Marginal Zone B-cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features"Am J Pathol.. 160. 1435-1443 (2002)
Description
「研究成果報告書概要(欧文)」より
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