| Project/Area Number |
13670410
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | NATIONAL CANCER CENTER RESEARCH INSTITUTE EAST |
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Principal Investigator |
HANAOKA Tomoyuki NATIONAL CANCER CENTER RESEARCH INSTITUTE EAST, EPIDEMIOLOGY AND BIOSTATISTICS DIVISION, SECTION HEAD, 支所・臨床疫学研究部, 室長 (00228503)
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| Co-Investigator(Kenkyū-buntansha) |
YAMANO Yuko SHOWA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF HYGIENE AND PREVENTIVE MEDICIINE, LECTURER, 医学部・衛生学, 講師 (30167580)
HARA Kunio INSTITUTE FOR SCIENCE OF LABOUR, RESEARCH DIVISION, RESEARCH GROUP LEADER, 研究部, 研究グループ長 (40250047)
ICHIBA Masayoshi SAGA MEDICAL SCHOOL, DEPARTMENT OF COMMUNITY HEALTH SCIENCE, ASSOCIATE PROFESSOR, 社会医学, 助教授 (60184628)
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| Project Period (FY) |
2001 – 2002
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| Keywords | ENVIRONMENTAL EPIDEMIOLOGY / MOLECULAR EPIDEMIOLOGY / BIOMARKER / ENVIRONMENTAL CARCINOGEN / POLYCYCLIC AROMATIC HYDROCARBON / DNA ADDUCT |
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| Research Abstract |
THE PURPOSE OF THIS STUDY WAS TO EXAMINE (1) MORE SENSITIVE AND RELIABLE ANALYTICAL METHODS OF INTERNAL EXPOSURE MARKERS AND DNA ADDUCTS, (2) INDIVIDUAL FACTORS AFFECTING ON LEVELS OF INTERNAL EXPOSURE MARKERS AND DNA ADDUCTS, (3) VALIDITY OF THESE BIOMARKERS IN OCCUPATIONAL SETTINGS, COKE OVEN WORKERS EXPOSED TO POLYCYCLIC AROMATIC HYDROCARBONS AT A HIGH LEVEL. DEVELOPMENT OF ANALYTICAL METHODS OF INTERNAL EXPOSURE MARKERS AND DNA ADDUCTS IS ONGOING. WE MADE A PROTOCOL OF THE VALIDATION STUDY OF THESE BIOMARKERS, OBTAINED IRB APPROVAL, STARTED TO OBTAIN BIOLOGICAL SAMPLES IN COKE OVEN WORKERS. CONCERNING INDIVIDUAL VARIATION OF THESE MARKERS, WE OBSERVED THAT 1-HYDROXYPYRENEANDAROMATIC DNAADDUCTS WEREAFFECTED BY CYP1A1 OR NAT2 GENOTYPES. 8-HYDROXYDEOXYGUANOSINE IN WHITE BLOOD CELL-DNA WAS NOT ELEVATED IN SUBJECTS EXPOSED TO POLYCYCLIC AROMATIC HYDROCARBONS ATA HIGH LEVEL. THE MESSENGER RNA OF CYP1B1 IN WHITE BLOOD CELL WAS OBSERVED TO RELATE WITH SMOKING IN COKE OVEN WORKERS.
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