2002 Fiscal Year Final Research Report Summary
Medicolegal study on alcohol-induced sudden death
| Project/Area Number |
13670433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
HATAKE Katsuhiko Nara Medical University, Legal Medicine, Professor, 医学部, 教授 (40164842)
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| Co-Investigator(Kenkyū-buntansha) |
WAKABAYASHI Ichiro Yamagata University, School of Medicine, Hygiene and Preventive Medicine, Professor, 医学部, 教授 (70220829)
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| Project Period (FY) |
2001 – 2002
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| Keywords | rat / thoracic aorta / superior mesenteric artery / EDHF / vasodilator nerve / CGRP / NO |
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| Research Abstract |
1. Thoracic aortas isolated from the rats that had been administered 5% ethanol for 8 weeks were used for measurement of isometric contraction. We obtained the results that choronic ethanol administration to rats induces ex vivo hypocontractility of the isolated aortas through depression of PKC-specific signal transduction of vascular smooth muscle.
2. In rat isolated superior mesenteric artery, isometric tension was measured for vascular response to various agonists and transmural electric stimulation. First, it was demonstrated that ethanol inhibit the relaxation mediated by endothelium-derived hyperpolarizing factor (EDHF). In another experiment using superior mesenteric artery, transmural electric simulation causes the contraction. We obtained the results that the contraction, which is mediated by adrenergic nerve and modulates calcitonin-gene related pepride(CGRP) and nitric oxide, is inhibited by ethanol.
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