2002 Fiscal Year Final Research Report Summary

The diagnostic and pathological significance of soluble CD163 in rheumatoid arthritis

Research Project

Project/Area Number	13670464
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	内科学一般
Research Institution	Kagoshima University
Principal Investigator	MATSUYAMA Takami Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (30145479)
Co-Investigator(Kenkyū-buntansha)	NAKAMURA Motoyuki Kagoshima University, Faculty of Medicine, Research Associate, 医学部, 助手 (30343362)
Project Period (FY)	2001 – 2002
Keywords	soluble CD163 / rheumatoid arthritis / hemoglobin / hepatitis
Research Abstract	The serum levels of soluble CD163 reflected the activity of rheumatoid arthritis. Additionally, the serum levels of soluble CD163 were elevated in active hepatitis. The shedding of soluble CD163 was inhibited by tissue inhibitor of metalloproteinase 3. This finding suggests that ADAM family proteinase might be involved in the cleavage of membranous CD163. The complex of haptoglobin and hemoglobin was bound to soluble CD163 as previously reported. Additionally, we found that hemoglobin alone could bind to soluble CD163.

(2 results)