2002 Fiscal Year Final Research Report Summary
Molecular cloning of a Src protease
| Project/Area Number |
13670516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Fukui medical University |
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Principal Investigator |
ITO Nobuyuki Fukui Medical Univ., University Hospital, lecturer, 医学部附属病院, 講師 (30273668)
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| Co-Investigator(Kenkyū-buntansha) |
TAMURA Shinji Osaka Univ. Graduate Sch. Of Medicine, assistant professor, 大学院・医学系研究科, 助手 (30243223)
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| Project Period (FY) |
2001 – 2002
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| Keywords | TGF-β / hepatocellular carcinoma / Src / protease / ubiquitination |
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| Research Abstract |
We have shown that loss of responsiveness against TGF-β contributes to the autonomous cell proliferation in hepatocellular carcinoma. We have also shown that Src protein was decreased by TGF-β in the cells whose proliferation was inhibited by TGF-β. These results indicate that some protease which is induced by TGF-β may regulate intracellular amounts of Src. This project aimed to find out to clone the protease. However, we have problems concerning with the reliability of the assay system for this protease and now we are fighting to establish the system. On the other hand, we found that the TGF-β-induced Src degradation seems to largely depend on increased Src ubiquitination by TGF-β. We are investigating the mechanisms of TGF-β-induced Src ubiquitination in hepatoma cells.
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[Publications] Tsushima H., Ito N., Tamura S., Matsuda Y, Inada M., Yabuuchi I., Imai Y., Nagashima R., Misawa H., Takeda H., Matsuzawa Y., Kawata S.: "Circulating transforming growth factor β1 as a predictor of liver metastasis after resection in colorectal cancer"Clin.Cancer Res.. 7. 1258-1262 (2001)
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[Publications] Kawada Y, Nagaretani H, Tamura S., Ohama T, Maruyama T, Hiraoka H, Yamashita S, Yamada A, Kiso S, Inui Y, Ito N, Kayanoki Y, Kawata S, Matsuzawa Y.: "Vascular endothelial dye function resulting from L-arginine deficiency in a patient with lysinuric protein in tolerance"J.Clin.Invest.. 108. 717-724 (2001)
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[Publications] Sakuda S, Tamura S, Yamada A, Miyagawa J, Yamamoto K, Kiso S, Ito N, Higashiyama S, Taniguchi N, Kawata S., Matsuzawa Y: "NF-kB activation in non-parenchymal liver cells after partial hepatectomy in rats : possible involvement in expression of heperin-binding EGF-like growth factor"J.Hepatol.. 36. 527-533 (2002)
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[Publications] Saito K, Inoue S, Saito T, Kiso S, Ito N, Tamura S, Watanabe H, Takeda H, Misawa H, Togashi H, Matsuzawa Y, Kawata S.: "Augmentation effect of postprandial hyperinsulinaemia on growth of human hepatocellular carcinoma"Gut. 51. 100-104 (2002)
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