2001 Fiscal Year Annual Research Report

Helicobacter pylori持続感染と免疫関連遺伝子多型との関連の検討

Research Project

Project/Area Number	13670519
Research Institution	Shimane Medical University
Principal Investigator	足立経一島根医科大学, 医学部, 助教授 (50192969)
Co-Investigator(Kenkyū-buntansha)	門脇泰憲島根医科大学, 医学部, 助手 (50322475)
Keywords	Helicobacter pylori / Mannose-binding lectin / IFNGRI / TNF-α
Research Abstract	Helicobacter pylori持続感染と免疫関連遺伝子多型との関連の検討について,平成13年度には本研究を遂行するにあたって,島根医科大学倫理委員会の承認を得たのち,面談および文書による十分なインフォームドコンセントのもとに同意が得られた受診者500名において,H.pylori感染の有無について保存血清にて測定を行なった.さらに,全白血球分画よりgenomic DNAを抽出し,現在保存中である.本研究にて,検討を行なうMannosebinding lectin(MBL)の4つのpolymorphic siteの解析についてのsequence specific priming-polymerase chain reaction(SSP-PCR)法,Interferon-α(IFN-α)の特異的受容体であるIFNGR1のgenetic polymorphismの解析についてのmismatch-polymerase chain reaction後のFok1によるdigestionと電気泳動を行うPCR/RFLP法,Tumor necrosis factor-α(TNF-α)のプロモーターであるTNF(-308)におけるpolymorphismの解析についてのallele-specific polymerase chain reaction(ASPCR)法について予備的検討を行ない,解析法については習熟してきている.来年度には,実際の検討対象となった健診受診者における解析を遂行していく予定である.本研究を行なっていく過程で,長期のH.Pylori感染によって血中HDL-コレステロールが低下していることを見いだし,H.Pylori感染が動脈硬化に関与している可能性を指摘し,英文誌のHelicobacterに投稿し,現在印刷中の状態である.

Research Products
(12 results)

All Other

All Publications (12 results)

[Publications] Akira Kawamura, et al.: "Prevalence of functional dyspepsia and its relationship with Helicobacter"Journal of Gastroenterology and Hepatology. 16(4). 384-388 (2001)
[Publications] Akira Kawamura, et al.: "Prevalence of irritable bowel syndrome and its relationship with"American Journal of Gastroenterology. 96. 1946 (2001)
[Publications] Kyoichi Adachi, et al.: "Efficacy of ecabet sodium for Helicobacter pylori eradication triple"Alimentary Pharmacology & Therapeutics. 15(8). 1187-1191 (2001)
[Publications] Kyoichi Adachi, et al.: "Influence of Helicobacter pylori infection and cetraxati on gastric"Journal of Gastroenterology and Hepatology. 16(11). 1211-1216 (2001)
[Publications] Kyoichi Adachi, et al.: "Predominant nocturnal acid reflux in patients with Los Angeles grade C"Journal of Gastroenterology and Hepatology. 16(11). 1191-1196 (2001)
[Publications] Ishihara S, et al.: "Intragastric distribution of Helicobacter pylori during short-term"Alimentary Pharmacology & Therapeutics. 15(9). 1485-1491 (2001)
[Publications] Ryo Fukuda, et al.: "Gastrointestinal stromal tumor with a novel mutation of KIT"Internal Medicine. 40(4). 301-303 (2001)
[Publications] Hirofumi Fujishiro, et al.: "Influence of Helicobacter pylori infection on the pravalence of reflux"Journal of Gastroenterology and Hepatology. 16(11). 1217-1221 (2001)
[Publications] Hashimoto T, et al.: "Safety and efficacy of glucagon as a premedication for upper"Alimentary Pharmacology & Therapeutics. 16(1). 111-118 (2002)
[Publications] Adachi K, et al.: "Nizatidine and cisapride enhance salivary secretion in humans"Alimentary Pharmacology & Therapeutics. 16(2). 297-301 (2002)
[Publications] Mika Yuki, et al.: "Is computerized bowel sound auscultation system useful for"American Journal of Gastroenterology. (in press).
[Publications] Toshiharu Takashima, et al.: "Cardiovascular risk factors in subjects with Helicobacter pylori infection"Helicobacte. (in press).

2001 Fiscal Year Annual Research Report

Helicobacter pylori持続感染と免疫関連遺伝子多型との関連の検討

Principal Investigator

足立 経一 島根医科大学, 医学部, 助教授 (50192969)

Research Products

[Publications] Akira Kawamura, et al.: "Prevalence of functional dyspepsia and its relationship with Helicobacter"Journal of Gastroenterology and Hepatology. 16(4). 384-388 (2001)

[Publications] Akira Kawamura, et al.: "Prevalence of irritable bowel syndrome and its relationship with"American Journal of Gastroenterology. 96. 1946 (2001)

[Publications] Kyoichi Adachi, et al.: "Efficacy of ecabet sodium for Helicobacter pylori eradication triple"Alimentary Pharmacology & Therapeutics. 15(8). 1187-1191 (2001)

[Publications] Kyoichi Adachi, et al.: "Influence of Helicobacter pylori infection and cetraxati on gastric"Journal of Gastroenterology and Hepatology. 16(11). 1211-1216 (2001)

[Publications] Kyoichi Adachi, et al.: "Predominant nocturnal acid reflux in patients with Los Angeles grade C"Journal of Gastroenterology and Hepatology. 16(11). 1191-1196 (2001)

[Publications] Ishihara S, et al.: "Intragastric distribution of Helicobacter pylori during short-term"Alimentary Pharmacology & Therapeutics. 15(9). 1485-1491 (2001)

[Publications] Ryo Fukuda, et al.: "Gastrointestinal stromal tumor with a novel mutation of KIT"Internal Medicine. 40(4). 301-303 (2001)

[Publications] Hirofumi Fujishiro, et al.: "Influence of Helicobacter pylori infection on the pravalence of reflux"Journal of Gastroenterology and Hepatology. 16(11). 1217-1221 (2001)

[Publications] Hashimoto T, et al.: "Safety and efficacy of glucagon as a premedication for upper"Alimentary Pharmacology & Therapeutics. 16(1). 111-118 (2002)

[Publications] Adachi K, et al.: "Nizatidine and cisapride enhance salivary secretion in humans"Alimentary Pharmacology & Therapeutics. 16(2). 297-301 (2002)

[Publications] Mika Yuki, et al.: "Is computerized bowel sound auscultation system useful for"American Journal of Gastroenterology. (in press).

[Publications] Toshiharu Takashima, et al.: "Cardiovascular risk factors in subjects with Helicobacter pylori infection"Helicobacte. (in press).

足立経一島根医科大学, 医学部, 助教授 (50192969)