2002 Fiscal Year Final Research Report Summary
Development of noninvasive procedure for diagnosis of NASH and of therapeutic strategy
| Project/Area Number |
13670524
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Kochi medical School |
|---|
Principal Investigator |
SAIBARA Toshiji Kochi medical School, First dept. Med., Assistant Professor, 医学部附属病院, 講師 (60145125)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AKISAWA Naoaki Kochi medical School, First dept. Med., Assistant Professor, 医学部附属病院, 助手 (00322280)
TODA Katsumi Kochi medical School, MEDICAL CHEMISTRY, Associated Professor, 医学部, 助教授 (40197893)
OGAWA Yoshihiro Kochi medical School, RADIOLOGY, Associated Professor, 医学部, 助教授 (90152397)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Keywords | STEATOHEPATITIS / COMPUTED TOMOGRAPHY / FERRITIN / PLATELET / AGE |
|---|
| Research Abstract |
The pathological features of NASH are associated with the pathological features most commonly seen in alcoholic liver disease itself. However, liver biopsy is a surgical procedure and a serious complication is inevitable at a very low rate. In this study, we investigated to find a noninvasive procedure for a diagnosis of NASH. A multivariated analysis revealed that patients with severe hepatic steatosis defined by using liver/spleen ratio<0 and age>50 years old were two most important factors. Plasma ferritin and platelet number were also useful markers of NASH. Venosection was a useful strategy for NASH with elevated ferritin levels. Randomized therapeutic trial using metformin and PPAR-γ ligand is in process.
|
