2002 Fiscal Year Final Research Report Summary
Promoter region hypermethylation of cell cycle related gene in hepatocarcinogenesis
| Project/Area Number |
13670539
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
SASAKI Shigeru Sapporo Medical University, School of Medicine, Instructor, 医学部, 助手 (10305229)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Fumio Sapporo Medical University, School of Medicine, Associate Professor, 医学部, 講師 (90223180)
YAMAMOTO Hiroyuki Sapporo Medical University, School of Medicine, Instructor, 医学部, 助手 (40332910)
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| Project Period (FY) |
2001 – 2002
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| Keywords | p16 / cell cycle / suppressor gene / methylation / hepatocarcinogenesis / early diagnosis / risk factor for carcinogenesis / bio-marker for carcinogenesis |
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| Research Abstract |
Inactivation of the p16 (INK4A) tumor suppressor gene by promoter region hypermethylation has been shown not only in many types of tumor, including hepatocellular carcinoma (HCC). Our previous study suggested that methylation of the p16 promoter region and the resulting loss of p16 protein expression are early events in a subset of hepatocarcinogenesis.
The objective of this study was to determine the usefulness of the loss of p16 protein expression and the methylation of the p16 promoter region as a prognostic factor for hepatocarcinogenesis.
In univariate analysis, loss of p16 protein was significantly correlated with hepatocarcinogenesis (p<0.05). In multivariate analysis, sex, age, fibrosis and loss of p16 protein expression retained independent prognostic significance.
Our results suggest that the loss of p16 protein expression are early events in a subset of hepatocarcinogenesis and that their detection is useful to follow up chronic hepatitis patients with a high risk for developing HCC, such as those with HBV or HCV infections.
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Research Products
(10 results)
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[Publications] Sasaki S., Yamamoto H., Kaneto H., Ozeki I., Adachi Y., Takagi H., Matsumoto T., Itoh H., Nagakawa T., Miyakawa H., Muraoka S., Fujinaga A., Suga T., Satoh M., Itoh F., Endo T., Imai K.: "Differential roles of alterations of p53, p16, and SMAD4 expression in the progression of intraductal papillary-mucinous tumors of the pancreas"Oncol Rep. 10. 21-25 (2003)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Takahashi H., Endo T., Yamashita K., Arimura Y., Yamamoto H., Sasaki S., Itoh F., Hirata K., Imamura A., Kondo M., Sato T., Imai K.: "Mucin phenotype and microsatellite instability in early multiple gastric cancers"Int J Cancer. 100. 419-424 (2002)
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「研究成果報告書概要(欧文)」より
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[Publications] Kaneto H., Sasaki S., Yamamoto H., Itoh F., Toyota M., Suzuki H., Ozeki I., Iwata N., Ohmura T., Satoh T., Karino Y., satoh T., Toyota J., Satoh M., Endo T., Omata M., Imai K.: "Detection of hypermethylation of the p16 (INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus"GUT. 48. 372-377 (2001)
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「研究成果報告書概要(欧文)」より
