2003 Fiscal Year Final Research Report Summary
Bronchila asthma and new Th2 type gene-ST2
| Project/Area Number |
13670612
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Jichi Medical School |
|---|
Principal Investigator |
SUGIYAMA Yukihiko Jichi Medical School, Dept.of Medicine, Professor, 医学部, 教授 (70183415)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOMINAGA Shin-ichi Jichi Medical School, Professor, 医学部, 教授 (70155571)
OSHIKAWA Katsuhisa Jichi Medical School, Dept.of Medicine, Lecturer, 医学部, 講師 (30326821)
|
|---|
| Project Period (FY) |
2001 – 2003
|
| Keywords | Bronchial asthma / Th2 / ST2 / Allegic inflammation |
|---|
| Research Abstract |
The human ST2 gene can be specifically induced by growth stimulation in fibroblastic cells, and ST2 protein is expressed preferentially in helper T cell type-2 (Th2) cells.
(1)Soluble ST2 protein levels in Asthma
We examined patients with atopic asthma and found a significant increase of serum ST2 level in the patients **h asthma with an acute exacerbation. This increase correlates well with the severity of asthma exacerbation.
(2)Animal models
1)LPS, IL1β, IL-6 and TNF αinduced ST2 mRNA expression in a murine alveolar macrophage cell line, MH-S cells. And pretreatment with ST2 protein reduced the protein production of such pro-inflammatory cytokines.
2)Our murine models suggest that increases in endogenous mST2 protein after allergen exposure may modulate Th2-mediated airway inflammation, and that in vivo gene transfer of mST2 can be applicable to use in a novel immunotherapy for allergic diseases.
(3)Th1/Th2 imbalance and pulmonary fibrosis
The serum levels of ST2 of idiopathic pulmonary fibrosis (IPF) in the stable state did not differ from those in the healthy control group, while the serum levels of ST2 of IPF in the acute exace bation group were significantly higher than those of stable or healthy control group.
|
