2002 Fiscal Year Final Research Report Summary
The features of saccharides on the LPS of Hemophilus influenzae which elicits Guillain-Barre syndrome
| Project/Area Number |
13670631
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | CHIBA UNIVERSITY |
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Principal Investigator |
HATTORI Takamichi Chiba University, Graduate School of Medidne, Professor, 大学院・医学研究院, 教授 (30114317)
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| Co-Investigator(Kenkyū-buntansha) |
NODA Kimitoshi Chiba University, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (60164703)
KUWABARA Satoshi Chiba University, University Hospital, Lecturer, 医学部附属病院, 講師 (70282481)
MORI Masahiro Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (70345023)
SEKI Hiroko Dept. of analysis center, Chiba Univ., Assistant, 分析センター, 助手 (60114245)
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| Project Period (FY) |
2001 – 2002
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| Keywords | Guillain-Barre syndrome / Haemophilus influenzae / gangliosides / GM1 / LPS |
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| Research Abstract |
We tested sera from 46 patients with Guillain-Barre syndrome (GBS), and found elevated anti-Haemophilus influenzae antibody in 13% of GBS patients. The GBS patients after Haemophilus influenzae infection showed uniform clinical and laboratory features : less sensory or cranial nerve involvement, and more pure motor axonal degeneration on electrophysiology. We have reported these results on a journal (Brain 2000 ; 123 : 2171-8). Therefore, we got six species of Haemophilus influenzae from GBS patients. We extracted lipopolysaccharides(LPS) from the bacteria, and showed the presence of saccharides on the LPS.
We found that the GBS patients after Haemophilus influenzae infection recovered well, and that this bacterial infection was good prognostic factor in GBS. We reported the results on the Journal of Neurology, Neurosurgery and Psychiatry(2001 ; 70 : 560-2).
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