2002 Fiscal Year Final Research Report Summary
Proposal of the new concept, "Platelet VEGF"
| Project/Area Number |
13670659
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kagoshima University |
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Principal Investigator |
HASHIGUCHI Teruto Kagoshima University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (70250917)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAKUCHI Munekazu Kagoshima University, Faculty of Medicine, Research Associate, 医学部, 助手 (20325814)
MARUYAMA Ikuro Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (20082282)
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| Project Period (FY) |
2001 – 2002
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| Keywords | VEGF / platelet / Crow-Fukase syndrome / POEMS syndrome / transgenic mouse / megakaryocyte / atherosclerosis / diabetic retinopathy |
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| Research Abstract |
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific potent mitogen that induces angiogenesis and microvascular hyperpermeability. Recently, megakaryocytes and platelets reportedly have contained VEGF in their cytoplasm. Furthermore, almost VEGF that detected in human serum has been derived from platelets. We present here the bio-activity of VEGF in platelets that enhances the endothelial cell proliferation. We also demonstrated that gelatinase A (matrix metalloproteinases-2) which is closely associated with vascular remodeling enhances VEGF levels released from platelets. We detected VEGF in the fibrin net of a thrombus and hypothesize that VEGF in platelets (platelet VEGF) and gelatinase A play an important role in angiogenesis and wound healing in conjunction with other platelet cytokines such as platelet-derived growth factor.
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[Publications] K. Michizono, F. Umehara, T. Hashiguchi, K. Arimura, E. Matsuura, O. Watanabe, N. Fujimoto, Y. Okada, and M. Osame: "Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome"Neurology. 26. 807-810 (2001)
Description
「研究成果報告書概要(欧文)」より
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